The A4 Study

The Knight ADRC is currently no longer enrolling research participants for this study.


What is the A4 Study?

The A4 Study (also known as the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s study) is a landmark clinical trial to prevent the memory loss associated with Alzheimer’s disease (AD). The A4 study is for individuals ages 65 to 85 who may be at risk for AD-related memory loss but who have no outward signs of the disease.

The A4 study is investigating a new treatment that may reduce the impact of a protein known as “amyloid” or “beta amyloid” which forms plaques in the brain. Scientists believe that the accumulation of amyloid in the brain may play a key role in the eventual development of AD-related memory loss.

The investigational treatment used in A4 targets the excess amyloid in the brain with the aim of slowing possible AD-related damage in the brain and delaying symptoms of memory loss.

Join the fight to prevent memory loss associated with Alzheimer's disease.

Why is research important?

The reality of Alzheimer disease (AD) is startling. Someone in the United States develops AD every 67 seconds, and 1 in 3 seniors dies with AD or another dementia. Alzheimer’s is the most common cause of memory and thinking impairment among persons age 65 and older.


Alzheimer disease is diagnosed based on gradual onset, slow progression of memory impairment, and general cognitive decline. At its earliest clinical stage, AD represents a decline from the person’s prior level of function and affects the person’s ability to carry out her everyday activities. Even with growing public awareness of the disease, it is estimated that almost half of all persons with symptoms go undiagnosed. Deaths from Alzheimer disease increased 71 percent from 2000 to 2013, while deaths from other major diseases, including heart disease, stroke, breast and prostate cancer, and HIV/AIDS, decreased.


*Statistics courtesy of Alzheimer’s Association 2015 Alzheimer’s Disease Facts and Figures 

Cognitive Testing

Memory and thinking tests


An electrocardiogram (ECG) is a test that records the electrical activity of the heart.

PET scan

A positron emission tomography (PET) scan is a type of imaging test.

MRI Scans

Magnetic resonance imaging (MRI) is another type of imaging test used to investigate the anatomy and physiology of the body.


You may receive compensation for your time & effort.

Blood & Urine Tests
Who can volunteer?

You may be eligible to participate in the A4 study if you:

  • Are 65 to 85 years old
  • Have normal thinking and memory abilities
  • Have an A4 study partner who has at least weekly contact with you and can answer questions once a year
  • Are willing and able to receive intravenous infusions (IV) of the investigational treatment or placebo (monthly infusions)
  • Be willing and able to participate in all required procedures for the duration of the A4 study
Learn More

You can learn more about the study by visiting the A4 Study Website.

How to Contact Us

To contact the A4 study coordinator at the Knight ADRC, please contact:

Marta Santos RN, BSN at (314) 286-2363.

A4 Brochure

You can download a PDF copy of the A4 brochure by clicking the image below.

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