2005 - 2006

Genetic Factors Modulating Quantitative Traits in LOAD
Anthony Hinrichs, Psychiatry

Metabolic Consequences of PINK 1 Mutations
Paul Kotzbauer, Neurology

 

Prospective Memory in DAT and APOE Genotype
Mark McDaniel, Psychology

 

2004 - 2005

 

Modulation of the Metabolism of Amyloid Precursor Protein (APP) by IGF-1 Signaling Pathway   
Investigator: Pang-Hsien (Benjamin) Tu, Pathology and Immunology

 

PET Radiotracer for Imaging Cholinergic Terminal Function in AD
Investigator: Zhude Tu, Radiology

 

Aging & Implicit Memory: Task Demands & Neurological Functioning
Investigator: Lisa Geraci, Psychology 

 

Roles of Neuregulin-1 in Age-Related Neuronal Changes
Investigator: Jianxin Bao, Otolaryngology

 

2003 - 2004

 

Toward a Molecular Understanding of Polyglutamine Disorders   
Investigator: Rohit Pappu, Biomedical Engineering 

 

Event Perception in Healthy Aging and Mild Dementia of the Alzheimer's Type
Investigator: Jeff Zacks, Psychology 

 

Impact of Stroke on Psychometric Performance in Normal and Mildly Demented Individuals
Investigator: Alex Dromerick, Neurology 

 

Acute and Chronic Effect of ß-Amyloid on Arteriolar Regulation
Investigator: Hans Dietrich, Neurosurgery 

 

Cerebral Microhemorrhage in Patients with Alzheimer's Disease
Investigator: Jin-Moo Lee, Neurology 

 

Role of Ubiquitination in Axonal Degeneration
Investigator: Toshiyuki Araki, Pathology & Immunology (Milbrandt Lab)

 

Does Repetitive Mild Traumatic Brain Injury Cause Long-Term Cognitive Impairment
Investigator: Lawrence Lewis, Emergency Medicine 

 

2002 - 2003

 

Identifying compounds that delay the age-related degenerative changes in Caenorhabditis elegans
Principle Investigator: Kerry Kornfeld

 

Effects of the APP mutation on the brain's normal capacity for neurogenesis
Principle Investigator: John Csernansky

 

Molecular pathways of death in grafted dopamine neurons
Principle Investigator: Gabriel A. de Erausquin

 

Computerized dynamic posturography (CDP) and mildly impaired subject balance
Principle Investigator: John W. Rohrbaugh

2010 - 2015

Novel protein biomarkers for Alzheimer’s disease in cerebrospinal fluid
Richard Perrin

 

Changing tau protein levels and tau protein isoforms in mouse models of dementia
Timothy Miller

 

APOE metabolism in AD and controls
Randall Bateman

 

2005 - 2010

Mapping substrate/y-secretase interactions 
Project Leader: Rahpael Kopan, Ph.D. 

PET Amyloid Imaging in the Elderly to Evaluate DAT Risk 
Project Leader: Mark Mintun, MD 

2000 - 2005

Identification of Genes that Modify Age of Onset of AD
Project Leader: Alison M. Goate

CNS apolipoprotein J: Role in Aß deposition
Project Leader: David M. Holtzman

Role of LRP and its Ligand tPA in LTP and Aging
Project Leader: Guojun Bu, Ph.D.

tMRI Exploration of Memory in Aging and Early-Stage DAT
Project Leader: Randy L. Buckner

2009 - 2013

Project 1 Preclinical AD predicts poststroke dementia
John C. Morris, MD

 

Project 2 Antecedent biomarkers of AD in CSF and plasma
David Holtzman, MD

 

Project 3 Markers for DAT: Control, variability, and personality
David Balota, Ph.D.

 

Project 4 Sequence variation in genes for biomarker proteins and age at onset
Alison Goate, DPhil

 

2004 - 2009

Informant-based dementia diagnosis in an African American community 
John C. Morris, MD

Biomarkers for pre-clinical and clinical AD
David M. Holtzman, MD

 

Attention in Healthy Aging & Early Stage DAT
David Balota, Ph.D.

1998 - 2003

Intellect and Alzheimer changes in the very old
Project Leader: John C. Morris

 

Mapping of Neuropathology in Healthy Aging and Dementia
Project Leader: Joseph L. Price

 

Frontal Control Systems and Memory in Aging and DAT
Project Leader: David A. Balota

 

Imaging Neuronal Loss with MRI/MRS in DAT and Controls
Project Leader: Benjamin Lee