The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Gita A Pathak
Project Title: Investigating the role of Depression and Polygenic score on cognitive impairment
Date: April 7, 2026 at 12:46 pm
Request ID: D2617
Aim 1: Identify the role of depression on cognitive impairment and its biomarkers
Aim 2: Identify the role of polygenic score of major depressive disorder on cognitive impairment and biomarkers
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Investigator: Li Sun
Project Title: Integrating cerebrospinal fluid proteomics to explore the biological mechanisms of cognitive progression heterogeneity in Aβ-positive individuals.
Date: April 6, 2026 at 12:12 pm
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Aim 1: Utilizing cognition data to identify cognitive heterogeneity of Aβ positive individuals.
Aim 2: Integrating CSF proteomics and other clinical data to elucidate the underlining mechanism of the heterogeneity.
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Investigator: Rafael Han
Project Title: Multiomic analyis of paired CSF and blood samples from CNS demyelinating disease patients.
Date: April 5, 2026 at 5:30 pm
Request ID: D2616
Aim 1: To compare CSF proteome among CNS demyelinating disease patients when compared to controls
Aim 2: To determine the changes in the ratio of proteome between CSF and blood among CNS demyelinating disease patients when compared to controls
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Investigator: David K. Johnson
Project Title: Longitudinal Study of the Transition From Healthy Aging to Alzheimer Disease – II
Date: March 31, 2026 at 2:50 pm
Request ID: D2615
Aim 1: To determine the temporal ordering of Alzheimer’s disease biomarkers in relation to person-specific cognitive change points.
Aim 2: To evaluate the predictive utility of individual and combined biomarkers for future cognitive change points and clinical progression.
Aim 3: To characterize domain-specific cognitive trajectories associated with biomarker profiles.
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Investigator: Jeremy Strain
Project Title: Cognitive Association in VCID with imaging, and Novel Multiomics
Date: March 30, 2026 at 4:30 pm
Request ID: D2614
Aim 1: Does the frequency/growth in distinct WMH spatial patterns associate with dementia status (CDR/CDR-SoB).
Aim 2: Do cellular and molecular pathways via CSF proteomics and metabolomics that associate with distinct WMH spatial patterns associate with dementia status (CDR/CDR-SoB).
Aim 3: Does the frequency/growth in distinct WMH spatial patterns associate with cognitive performance (ADSP-PHC).
Aim 4: Do cellular and molecular pathways via CSF proteomics and metabolomics that associate with distinct WMH spatial patterns associate with cognitive decline (ADSP-PHC).
Investigator: dehao yang
Project Title: 机器学习模型筛选出的特征变量预测AD风险
Date: March 28, 2026 at 12:30 am
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Aim 1: 用两步MR寻找AD风险变量进行特征筛选，再运用机器学习模型进行模型构建，放入ADNI进行验证，最后用GBD数据进行AD风险的预测。机器学习特征变量预测AD已有一些研究，但是使用GBD数据库预测全球风险的文章现在并没有，有一定新颖性
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Investigator: Nicole McKay
Project Title: Investigating Excitatory/Inhibitory Imbalance in Sporadic Alzheimer Disease
Date: March 19, 2026 at 10:15 am
Request ID: D2613
Aim 1: Investigate how an electrophysiological measure of E/I imbalance (aperiodic slope) relates to clinical status and cognitive performance.
Aim 2: Understand the relationships between aperiodic slope and biomarkers of AD pathology (amyloid, tau, neurodegeneration).
Aim 3: Examine how neuroinflammation modulates the relationship between aperiodic slope and AD pathology.
Aim 4: [Future] Secondary aims will explore the relationship between our EEG measure of E/I imbalance (aperiodic slope) and complementary measures of functional dysregulation (fMRI and FDG).
Investigator: Yamei Tang
Project Title: Shared Proteomic Mechanisms of Cerebral Small Vessel Disease and Alzheimer’s Disease Comorbidity
Date: March 16, 2026 at 12:16 pm
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Aim 1: Identify CSF proteomic signatures associated with cerebral small vessel disease (CSVD) burden.
Aim 2: Investigate shared molecular pathways linking CSVD imaging burden to AD core pathologies.
Aim 3: Evaluate the interaction between baseline vascular risk factors (e.g., hypertension, diabetes) and CSF proteomic subtypes on neurodegeneration and cognitive decline.
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Investigator: Peter Millar
Project Title: Large language model (LLM)-assisted identification of atypical Alzheimer disease symptoms in Knight ADRC clinical notes
Date: March 6, 2026 at 5:56 pm
Request ID: D2612
Aim 1: Identify subset of Knight ADRC participants with atypical tau PET signatures and extract symptom history from longitudinal clinical notes.
Aim 2: Characterize patterns, timing, and frequency of clinical features across the subgroups.
Aim 3: Compare occurrences of atypical symptoms to other sub-groups of patients within the Knight ADRC dataset.
Aim 4: Validate an LLM-assisted note review model for detecting indicators of atypical AD phenotypes in a sub-clinical group.
Investigator: Paul Kotzbauer
Project Title: Protein Aggregation and Neurotransmitter Deficits in Parkinsons Disease
Date: March 6, 2026 at 2:17 pm
Request ID: D2611
Aim 1: Evaluate the relationship of developing thinking and gait problems with people with Parkinsons Disease, Lewy Body Dementia or a healthy control.
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