Affiliated Labs

The Ances Lab is a neuroscience research lab within the Department of Neurology at Washington University School of Medicine in St. Louis that is focused on:

Developing novel neuroimaging biomarkers of normal aging and neurodegeneration (including Alzheimer’s Disease (AD), Down syndrome (DS), HIV Associated Neurocognitive Disorders (HAND), Creutzfeld-Jacob Disease (CJD), autoimmune- mediated encephalitis (AIME), and neuroCOVID19).

Evaluating therapeutic interventions that will improve neurocognitive deficits and biomarkers associated with neurodegenerative disorders.

Bateman’s laboratory focuses on the causes, diagnosis, and future treatments of Alzheimer’s disease (AD). We directly measure the pathology and pathophysiology of AD in humans using multiple techniques. Our group uses a wide variety of assays and techniques from the most basic applications, such as quantitative measurement of stable-isotope labeled peptides, to clinical translational studies in diagnostic and therapeutic biomarkers for AD.

The Benzinger Lab is a member of the Neuroimaging Laboratory and of the Knight Alzheimer Research Imaging (KARI) Program at Washington University School of Medicine in St. Louis. Led by Dr. Tammie Benzinger, the Lab is focused on developing position emission tomography (PET) and magnetic resonance imaging (MRI) methods for the study of diseases of the central nervous system.

The Cirrito Lab focuses on processes that regulate Aβ within the interstitial fluid (ISF). To do so, we developed unique microdialysis and micro-immunoelectrode (MIE) technologies to measure Aβ specifically within the extracellular space of a living mouse. The Cirrito Lab also seeks to define the cellular pathways that link between sleep and Aβ.

The Clifford Lab’s goal has been to improve therapeutics for neurological disorders, with a particular focus on neurological complications of HIV.

The Center on Biological Rhythms and Sleep (COBRAS) enables researchers across diverse specialties and departments to readily investigate the impact of sleep and circadian rhythms on their disease of interest. COBRAS also serves as a platform for development of new collaborative projects and grants and can serve as a core for existing programs.

The Cognitive Technology Research Lab (CTRLab) uses technology to improve the assessment of cognition and to increase engagement in clinical studies. We primarily focus on approaches using smartphones and web-based assessments in clinical populations including Alzheimer’s disease and other neurodegenerative diseases.

The Cruchaga Lab is dedicated to advancing the understanding of neurodegenerative diseases such as Alzheimer disease, other dementias, and stroke, by generating, analyzing and leveraging multi-tissue multi-omic data from large and well characterized cohorts.

Plasticity is one of the hallmark features of the human brain. Use-driven plasticity is critically important for typical development as well as recovering from brain injury. Thus, the overarching goal of the Lab’s research is to better understand use-driven brain plasticity. To this end, the Lab uses various structural and functional MRI and behavioral phenotyping techniques.

The Fagan Lab has studied Alzheimer Disease from multiple angles for more than 20 years. Currently, Dr. Fagan and her lab members focus on fluid biomarkers of disease with a particular interest in identifying individuals with preclinical and early stage AD. To this end, Enzyme Linked Immunosorbent Assays (ELISA), bead-based immunoassays, and cutting edge single-molecule counting systems are all employed to study protein biomarkers in cerebrospinal fluid. Most recently, the Fagan Lab has also begun to study the applicability of plasma biomarkers over the full disease spectrum from Autosomal Dominant AD (ADAD) to all stages of Late Onset AD (LOAD).