A major goal of the Knight ADRC is to foster, facilitate and support research on dementia and aging. To this end, the Center recruits research participants to participate in longitudinal cognitive, neuropsychologic, imaging, and biomarker assessments. Three types of resources are available:

  • Data: includes clinical and cognitive measures as well as MRI and amyloid imaging scans
  • Tissue: includes frozen brain tissue, paraffin brain sections, antemortem CSF, DNA, fibroblast, dermal fibroblasts, plasma (fasting and non-fasting) and iPSC.
  • Participant: Eligible participants may be invited to enroll in the research of other investigators after appropriate review.

As with any mature (30+years), longitudinal study, our data is complex:  tests and procedures have been added and dropped,   enrollment criteria have changed, studies have started and ended (Parkinson’s disease, very old, Lewy body disease, stroke, etc.), and funding levels have varied.  Although we have data on over 3600 research participants, the sample size for a particular request will dwindle quickly depending on eligibility criteria and measures requested.  For example amyloid imaging was initiated in 2004; through August 31, 2010, 449 participants have undergone this assessment.  Of these 449 participants, 161 are enrolled in a younger cohort that receives a different set of neuropsychologic tests that would not be comparable to tests for the older cohort.  If other criteria are added, the sample size reduces quickly (e.g. if APOE4-positive participants with amyloid imaging are required, only 100 potential participants remain eligible).  If e4 homozygous participants are specified, then only 15 would remain eligible.  Additional diagnostic restrictions can also limit potential participants.  Comorbidities in an elderly sample are very common; requests for ‘pure’ Alzheimer’s disease with no depression, cerebrovascular disease, etc. are very difficult to fulfill.

Important Notice

Before initiating a resource request from the Center, review our Guidelines & Data Available page. Failure to review the provided documents may result in your request being delayed.