The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Hye Joo Son
Project Title: Study title : Longitudinal correlation between ocular and brain Aβ pathology using deep learning-enhanced ultra-high-resolution ocular amyloid PET across the cognitive aging spectrum
Date: March 1, 2025 at 4:32 am
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Aim 1: Using deep learning–based super-resolution techniques, we will enhance PET imaging resolution to assess whether ocular tracer uptake, as measured on routine brain amyloid PET/CT scans, correlates with brain amyloid burden and predicts cognitive decline over time.
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Investigator: Profofessor Vanessa Raymont, Dr Ivan Koychev
Project Title: Longitudinal Biomarker Trajectories and Event-Based Outcomes in Predicting Dementia Risk: A Joint Modelling Approach
Date: February 16, 2025 at 11:12 am
Request ID: D2514
Aim 1: Primary Objective: To determine how longitudinal changes in BBMs (e.g., p-Tau217, p-Tau181, Aβ1-42/40 ratio) predict time to dementia diagnosis/MCI onset.
Aim 2: Secondary Objective 1: Event-Specific Contributions of Biomarkers: To investigate the association between biomarker trajectories and specific cognitive or neuroimaging events, providing insights into disease progression pathways.
Aim 3: Secondary Objective 2: Predictive Power of Biomarkers: To compare the predictive power of individual BBMs for dementia risk using metrics such as Net Reclassification Index (NRI) and Integrated Discrimination Improvement (IDI).
Aim 4: Secondary Objective 3: To provide dynamic, personalized dementia risk predictions based on individual biomarker trajectories.
Investigator: Joel Perlmutter
Project Title: Resting State Functional Connectivity in Alzheimer and Parkinson Diseases
Date: February 14, 2025 at 6:46 pm
Request ID: D2513
Aim 1: Examine resting state fMRI functional connectivity matrices and spectral biomarkers in participants with AD and PD and their respective control groups
Aim 2: Analyze the extent to which FC changes characteristic of AD and PD resemble features known to index level of arousal
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Investigator: Devin Drown
Project Title: A combined re-analysis of Alzheimer’s Disease and the Human Gut Microbiome
Date: February 6, 2025 at 5:37 pm
Request ID: D2512
Aim 1: I am an undergraduate researcher at the University of Alaska Fairbanks, working on an independent project to re-analyze multiple data sets. My goal is to take the raw sequence reads and process them all through the same databases to examine trends
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Investigator: Paul Aisen (USC, primary award), B. Joy Snider (Wash U sub award)
Project Title: Alzheimer Clinical Trial Consortium Brain Donation Progra
Date: February 6, 2025 at 2:58 pm
Request ID: D2511
Aim 1: To offer brain donation to clinical trial participants. Autopsy on these participants has the potential to provide meaningful data to confirm the impact of interventions on neuronal integrity, disease processes, as well as the impact brain and disease etiology may have on efficacy of different inte
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Investigator: Zhongwei Zhang
Project Title: Multi-shell Diffusion Modeling
Date: January 31, 2025 at 11:24 pm
Request ID: D2510
Aim 1: Investigating the Impact of Pre-Processing on Multi-Shell Diffusion Models
Aim 2: Multi-Shell Hybrid Models Development
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Investigator: Oskar Hansson
Project Title: Biological staging of AD using plasma %p-tau217 and eMTBR-tau243
Date: January 27, 2025 at 8:26 pm
Request ID: D2509
Aim 1: Derive a biological staging model of AD using plasma %p-tau217 and eMTBR-tau243
Aim 2: Compare the biological staging model to other AD-relevant measures
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Investigator: Haotian Zou
Project Title: Developing an Integrative Predictive Model for Alzheimer’s Disease Progression Using Multi-Modal Data from Knight-ADRC and Other Cohorts
Date: January 22, 2025 at 2:00 pm
Request ID: D2508
Aim 1: To develop a robust predictive model for AD progression by integrating multi-modal data, including longitudinal clinical data, MRI data, and omics data.
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Investigator: Abdallah Eteleeb
Project Title: Unraveling the impact of disease comorbidities in Alzheimer’s disease through multi-omics integration
Date: January 22, 2025 at 9:58 am
Request ID: D2507
Aim 1: Identify comorbidities associated with specific molecular profiles of Alzheimer’s disease through multi-omics data integration
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Investigator: Dr. Chengjie Xiong
Project Title: Investigate racial differences in the CDR item level data.
Date: January 13, 2025 at 5:04 pm
Request ID: D2506
Aim 1: Assess CDR item level data for possible racial differences along with AD biomarkers
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