The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Head, Denise
Project Title: Structural and Psychometric Correlates of Lifetime Engagement in Physical Activity
Date: December 21, 2021 at 5:29 pm
Request ID: S0620
Aim 1:
Aim 2:
Aim 3:
Aim 4:
Investigator: Mintun, Mark
Project Title: amyloid binding properties, pharmacokinetics and safety, of F-AV-19
Date: December 21, 2021 at 5:29 pm
Request ID: S0618
Aim 1:
Aim 2:
Aim 3:
Aim 4:
Investigator: sheline, yvette
Project Title: PET Amyloid Plaque Imaging in Late Life Depression
Date: December 21, 2021 at 5:29 pm
Request ID: S0607
Aim 1:
Aim 2:
Aim 3:
Aim 4:
Investigator: Duntley, Stephen
Project Title: GHB Tolerability Study in AD population
Date: December 21, 2021 at 5:29 pm
Request ID: S0533A
Aim 1:
Aim 2:
Aim 3:
Aim 4:
Investigator: Morris, John C.
Project Title: Autopsy Program Satisfaction in the Memory and Aging Project
Date: December 21, 2021 at 5:29 pm
Request ID: S0717
Aim 1:
Aim 2:
Aim 3:
Aim 4:
Investigator: David Carr
Project Title: Theraputic effects of intransasally-administered insulin in adults with aMCI or mild AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1306
Aim 1: To examine the effects of intranasally-administered insulin (INI) on cognition in aMCI and AD
Aim 2: To examine the effects of INI on entorhinal cortex and hippocampal atrophy in aMCI and AD
Aim 3: To examine the effects of INI on CSF biomarkers in aMCI and AD
Aim 4: Exam global measures of cognitive performance over 12 months of INI treatment compared to placebo
Investigator: David Van Essen
Project Title: Lifespan Pilot Supplement for WashU-UMinn Human Connectome Project (HCP) Consortium
Date: December 21, 2021 at 5:28 pm
Request ID: S1305
Aim 1: To determine what modifications of current HCP procedures are needed for older adults
Aim 2: To compare data acquired by modified HCP methods to data from previous studies in older adults
Aim 3: To estimate effect sizes to inform group sizes needed to demonstrate age differences in connectivity
Aim 4: To pilot behavioral phenotyping inolder adults using NIH Toolbox and other HCP measures
Investigator: Nupur Ghoshal/ Clay Semenkovich
Project Title: Clinical and Biomarker Characterization of Inherited Frontotemporal Dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1303
Aim 1: A cohort of FTD caused by mutation in MAPT and GRN will be established, cognitively characterized, a
Aim 2: Use plasma and CSF to establish tau biomarker profiles that are unique to presymptomatic individuals
Aim 3:
Aim 4:
Investigator: yvette Sheline
Project Title: Escitalopram Effects on CSF AB Total Concentration
Date: December 21, 2021 at 5:28 pm
Request ID: S1302
Aim 1: Compared to controls, subjects who get the 20mg/dayx2wks will have lower CSF concentration of A-beta
Aim 2:
Aim 3:
Aim 4:
Investigator: Mitchell Sommers
Project Title: False hearing and cognitive control in DAT
Date: December 21, 2021 at 5:28 pm
Request ID: S1304
Aim 1: Determine if impaired cognitive control in DAT affects response bias
Aim 2: Determine if individuals with DAT rely more on context for speech perception
Aim 3:
Aim 4: