The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Jeffrey M. Zacks
Project Title: Everyday Memory in Aging and Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1702
Aim 1: Test the hypothesis that age and biomarkers for AD neuropathology are associated with impairments in the ability to notice and remember changes.
Aim 2: Use an experimental approach to test one potential mechanism: reduced fidelity of medial temporal activity patterns leading to impaired detection of discrepancy.
Aim 3: Attempt to remediate age- and AD-related memory deficits by enhancing elders� encoding of new events in relation to related previous events with a cuing procedure.
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Investigator: John C. Morris
Project Title: Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer�s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1701
Aim 1: To show that loss of blood-brain barrier (BBB) integrity links vascular injury to neuronal injury in AD
Aim 2: Examine temporal relationship between BBB permeability, cerebral blood flow (CBF) and white matter lesions
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Investigator: Jason Hassenstab
Project Title: Pilot Study: Ambulatory Cognitive Assessments
Date: December 21, 2021 at 5:28 pm
Request ID: S1610
Aim 1: Determine the feasibility and utility of ambulatory cognitive assessments using measurment burst design.
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Investigator: Ganesh Babulal
Project Title: Racial differences in Alzheimer�s disease biomarkers and driving behavior
Date: December 21, 2021 at 5:28 pm
Request ID: S1609
Aim 1: We will determine, in a sample of 60 older adults, aged 65 years and older, with normal baseline cognition (Clinical Dementia Rating of 0), whether there are differences in values of cerebrospinal fluid (CSF) biomarkers and imaging amyloid uptake between African Americans and Caucasians
Aim 2: In the same sample, we will examine whether there are differences in African Americans and Caucasians cross-sectionally and longitudinally in daily driving behavior using an in-vehicle recording device and on a road test
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Investigator: Eric McDade
Project Title: Cerebrovascular Reactivity in the Presence of Cerebral Amyloid and Cerebrovascular Disease:
Date: December 21, 2021 at 5:28 pm
Request ID: S1608
Aim 1: To explore the impact of cerebral amyloid on cerebrovascular reactivity
Aim 2: To explore the impact of age and vascular related comorbidities in the relationship of cerebrovascular reactivity and cerebral amyloid
Aim 3: To explore the the impact of cerebrovascular reactivity as a moderator of amyloid related cognitive impairment
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Investigator: B, Joy Snider (WU site)
Project Title: Protocol 221AD301 A phase 3 Multicenter, RCT to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer�s Disease (ENGAGE Study)
Date: December 21, 2021 at 5:28 pm
Request ID: S1607
Aim 1: Evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the CDR-SB score as compared with placebo in subjects with early AD.
Aim 2: Evaluate the efficacy of aducanumab on MMSE, ADAS-Cog13, ADCS-ADL
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Investigator: Tammie Benzinger
Project Title: An open label, multicenter study, evaluating the imaging characteristics of a follow-up 18F-AV-1451 scan in subjects who have had a prior 18F-AV-1451 scan
Date: December 21, 2021 at 5:28 pm
Request ID: S1509
Aim 1: To assess the rate of change of tau deposition as measured by 18F-AV-1451 uptake over time.
Aim 2: To expand the 18F-AV-1451 safety database.
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Investigator: John C. Morris, MD
Project Title: Protocol 54861911ALZ2003: Investigating the Efficacy and Safety of JNJ-54861911 in Subjects who are Asymptomatic At Risk for Developing Alzheimer’s Dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1605
Aim 1: To deteremine whether treatment with JNJ-54861911 slows cognitive decline compared with placebo treatement, as measured by a composite cognitive measure, the Preclinical Alzheimer Cognitive Composite, in amyloid positive subjects who are asymptomatic at risk for developing Alzheimer’s dementia.
Aim 2: To assess the overall safety and tolerability of JNJ-54861911 versus placebo.
Aim 3: To assess the effect of JNJ-54861911 compared with placebo on the Clinical Dementia Rating (CDR) scale, including progression from CDR 0 to CDR 0.5 or higher
Aim 4: To assess the maintenance of JNJ-54861911 effects on markers of AB processing in CSF and plasma compared with placebo.
Investigator: Jeffrey M Zacks
Project Title: Improving everyday memory in healthy aging and early AD
Date: December 21, 2021 at 5:28 pm
Request ID: S2102
Aim 1: Test whether and how attention to event segmentation improves elders� memory for everyday activity at delays from minutes to weeks.
Aim 2: Test the hypothesis that effective event segmentation improves the resolution of elders� posterior/medial memory representations.
Aim 3: Test whether the mechanisms and consequences of segmentation improvement are maintained or impaired by early symptomatic Alzheimer�s disease.
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Investigator: Kevin Yarasheski
Project Title: Blood collection from individuals with APOE2/2, APOE2/3, APOE2/4, APOE3/3, APOE3/4 and APOE4/4 genotype to obtain plasma for the development and analytical validation of a plasma ApoE proteotype test
Date: December 21, 2021 at 5:28 pm
Request ID: S2103
Aim 1: The aim of this study is to collect plasma from individuals with APOE2/2, APOE2/3, APOE2/4, APOE3/3, APOE3/4 and APOE4/4 genotype to develop and analytically validate a plasma ApoE proteotype assay
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