The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Randall John Bateman, MD
Project Title: CNS Tau Kinetics in Healthy Aging and Alzheimer�s Disease
Date: [293]
Request ID: S1506
Aim 1: To measure physiological tau kinetics with the tau SILK method in the CSF of normal human participants.
Aim 2: To measure pathological tau kinetics with the tau SILK method in AD patients.
Aim 3: Differences between AD and controls will be assessed with kinetic models. We will address the question of whether tau kinetics in the CNS is altered in AD with either over-production or under-clearance.
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Investigator: Sarah Hartz
Project Title: Comparison of methods for return of results in Alzheimer’s studies
Date: [293]
Request ID: S1505
Aim 1: Evaluate whether returning imaging and genetic results to cognitively normal subjects by the telephone is inferior to returning results in person
Aim 2: Determine the cost to the study of returning results to cognitively normal subjects both in person and by telephone
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Investigator: Tom Morris
Project Title: Remembering with a Partner in Old Age: Compensatory or Protective Effects of Collaboration in Cognitive Dysfunction
Date: [293]
Request ID: S1504
Aim 1: To determine whether remembering with a long term partner can compensate for memory dysfunction
Aim 2: To examine whether impaired individuals remember better in collaboration with their partner vs. remembering alone
Aim 3: To investigate the specific processes and cognitive support strategies that predict better collaborative recall
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Investigator: Angela Curl
Project Title: Psychometric Testing of the CARS Driver Safety Tool
Date: [293]
Request ID: S1503
Aim 1: To test the psychometric reliability of the newly developed CARS Instrument
Aim 2: To test the psychometric validity of the newly developed CARS Instrument
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Investigator: Samantha Allison
Project Title: Developing a Spatial Navigation-Related Task for Detecting Preclinical AD
Date: [293]
Request ID: S1502
Aim 1: Assess the diagnostic accuracy of five spatial navigation-related tasks
Aim 2: Assess the reliability of five spatial navigation-related tasks
Aim 3: Assess the validity of five spatial navigation-related tasks
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Investigator: John Morris
Project Title: Antecedent Biomarkers for AD; The Adult Children Study
Date: [293]
Request ID: S1501
Aim 1: In the cross-sectional arm of this study we will determine the relationship across subjects of well-established risk factors for, and biomarkers of AD to measurements of regional circulation and metabolism (blood flow, aerobic glycolysis as well as total glucose and oxygen metabolism
Aim 2: In the longitudinal arm of this study we will determine the relationship of changes in clinical assessments and biomarkers of AD to changes in regional circulation and metabolism.
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Investigator: Catherine M. Roe
Project Title: Evaluating the feasibility of using a global positioning data acquisition system to assess driving safety and decline in older adults with and without preclinical Alzheimer disease.
Date: [293]
Request ID: S1407
Aim 1: To examine the feasibility of, and to develop the methodology for, the use of GPDAS to capture everyday driving behavior.
Aim 2: To compare driving performance using GPDAS in 10 adults with preclinical AD and 10 adult without.
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Investigator: Randall Bateman, Chihiro Sato
Project Title: Analysis of Tau Kinetics using Infusion of Stable Isotopes
Date: [293]
Request ID: S1406
Aim 1: What is the Half Life of Tau in the Human Central Nervous System
Aim 2: Is CSF Tau increased due to over-production or under-clearance
Aim 3: Are Tau Kinetics altered in Alzheimer’s Disease
Aim 4: How much should Tau be modulated by drugs which Target Tau
Investigator: Dave Balota
Project Title: Age Differences in Category Learning Strategies
Date: [293]
Request ID: S1405
Aim 1: To determine whether individual differences in category learning strategies differ between younger and older adults.
Aim 2: To examine the relationship between the volume of brain regions and category learning strategies in healthy older adults.
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Investigator: Alison Goate/Carlos Cruchaga
Project Title: Human cell models of dementia
Date: [293]
Request ID: S1404
Aim 1: To obtain and culture dermal fibroblasts from individuals carrying causative mutations associated with dementias (MAPT, GRN, C9ORF72, Non-DIAN PSEN1)
Aim 2: To obtain and culture dermal fibroblasts from individuals carrying risk variants associated with dementias (PLD3, TREM2, UNC5C)
Aim 3: To generate induced pluripotent stem cells (iPSCs) from dermal fibroblasts carrying causative mutations or risk variants associated with dementias
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