The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Guoyan Zhao
Project Title: Elucidating shared vascular mechanisms of neurodegeneration through uniform single-nucleus RNA transcriptomic analysis
Date: April 28, 2026 at 12:09 am
Request ID: D2624
Aim 1: Delineate vascular cell-specific transcriptomic changes across five NDDs and five brain regions
Aim 2: Identify candidate drugs through consensus in silico screening.
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Investigator: Suprateek Kundu
Project Title: Multimodal Biomarker Approaches for Risk Stratification and Screening in Alzheimer’s Disease
Date: April 25, 2026 at 1:09 pm
Request ID: D2623
Aim 1: To integrate baseline blood-based biomarkers with regional longitudinal structural brain atrophy changes, to predict future cognitive decline in cognitively unimpaired individuals, and infer significant interactions between regional neurodegeneration and p-tau217.
Aim 2: To integrate baseline blood-based biomarkers with regional longitudinal white matter hyperintensity (WMH) changes, to predict future cognitive decline in cognitively unimpaired individuals, and infer significant interactions between regional WMH and p-tau217.
Aim 3: To forecast future neurodegeneration in cognitively unimpaired individuals, by predicting long term brain atrophy and white matter hyperintensity changes based on longitudinal imaging data from earlier visits.
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Investigator: Katherine Goulden
Project Title: Neuropsychological Differences Between Early Neurodegenerative Disease and Suspected Functional Cognitive Disorder in Latino and Non-Latino Older Adults
Date: April 25, 2026 at 12:38 pm
Request ID: D2622
Aim 1: Characterize neuropsychological performance patterns across individuals with self-reported cognitive concerns and normal cognition as a group with suspected Functional Cognitve Disorder, biomarker-validated MCI and healthy controls.
Aim 2: . Identify neuropsychological indicators that distinguish FCD from neurodegenerative MCI. These are: inconsistent patterns of the Everyday Cognition self and study partner reports, measuring discrepancy between subjective report and objective performance neuropsychological tests.
Aim 3: Examine whether neuropsychological patterns differ between Hispanic/Latino and non‑Hispanic groups. This supports culturally valid diagnostic frameworks by checking differential performance profiles and accounting for language or education‑related testing artifacts and cultural differences.
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Investigator: Shant Afarian
Project Title: Blood-Brain Barrier Transport of Plasma Proteins in Cerebral Small Vessel Disease
Date: April 25, 2026 at 11:25 am
Request ID: D2621
Aim 1: Identify plasma proteins that show evidence of blood-brain barrier transport.
Aim 2: Determine whether CSVD burden is associated with altered BBB transport.
Aim 3: Identify structural and genetic determinants of altered BBB transport in CSVD.
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Investigator: Tae Youn Kwon
Project Title: External Validation of MRI-Derived Regional Tau Prediction and Its Clinical Utility for Tau Subtype and Cognitive Decline Analysis
Date: April 19, 2026 at 12:06 am
Request ID: D2620
Aim 1: To validate the performance of an MRI-based regional tau prediction model in an independent FTP tau-PET cohort and determine its generalizability across key demographic and disease-related subgroups.
Aim 2: To characterize spatial heterogeneity of predicted tau deposition by identifying tau subtypes from MRI-derived regional estimates and comparing them with subtype patterns derived from observed tau-PET.
Aim 3: To assess the relationship of MRI-predicted tau burden and subtype membership with baseline cognitive impairment and longitudinal cognitive decline in individuals across the Alzheimer’s disease spectrum.
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Investigator: Donohue
Project Title: Assessing design artifacts and added value of plasma ptau217 clocks
Date: April 17, 2026 at 11:16 am
Request ID: D2619
Aim 1: Assessing design artifacts in studies of plasma ptau217 clocks
Aim 2: Assessing added value of plasma ptau217 clocks
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Investigator: Yujia Luo
Project Title: Study on the Correlation between Frailty and Postoperative Delirium in Elderly Orthopedic Patients Based on NULISA Technology
Date: April 16, 2026 at 2:43 am
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Aim 1: In the Study on the Correlation between Frailty and Postoperative Delirium in Elderly Orthopedic Patients Based on NULISA Technology, we observed a significant elevation of pTau217 levels in patients presenting with delirium. Building upon this finding, we aim to further investigate the differences
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Investigator: Gita A Pathak
Project Title: Investigating the role of Depression and Polygenic score on cognitive impairment
Date: April 7, 2026 at 12:46 pm
Request ID: D2617
Aim 1: Identify the role of depression on cognitive impairment and its biomarkers
Aim 2: Identify the role of polygenic score of major depressive disorder on cognitive impairment and biomarkers
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Investigator: Li Sun
Project Title: Integrating cerebrospinal fluid proteomics to explore the biological mechanisms of cognitive progression heterogeneity in Aβ-positive individuals.
Date: April 6, 2026 at 12:12 pm
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Aim 1: Utilizing cognition data to identify cognitive heterogeneity of Aβ positive individuals.
Aim 2: Integrating CSF proteomics and other clinical data to elucidate the underlining mechanism of the heterogeneity.
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Investigator: Rafael Han
Project Title: Multiomic analyis of paired CSF and blood samples from CNS demyelinating disease patients.
Date: April 5, 2026 at 5:30 pm
Request ID: D2616
Aim 1: To compare CSF proteome among CNS demyelinating disease patients when compared to controls
Aim 2: To determine the changes in the ratio of proteome between CSF and blood among CNS demyelinating disease patients when compared to controls
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