The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: John C. Morris, MD
Project Title: Protocol 54861911ALZ2003: Investigating the Efficacy and Safety of JNJ-54861911 in Subjects who are Asymptomatic At Risk for Developing Alzheimer’s Dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1605
Aim 1: To deteremine whether treatment with JNJ-54861911 slows cognitive decline compared with placebo treatement, as measured by a composite cognitive measure, the Preclinical Alzheimer Cognitive Composite, in amyloid positive subjects who are asymptomatic at risk for developing Alzheimer’s dementia.
Aim 2: To assess the overall safety and tolerability of JNJ-54861911 versus placebo.
Aim 3: To assess the effect of JNJ-54861911 compared with placebo on the Clinical Dementia Rating (CDR) scale, including progression from CDR 0 to CDR 0.5 or higher
Aim 4: To assess the maintenance of JNJ-54861911 effects on markers of AB processing in CSF and plasma compared with placebo.
Investigator: John C. Morris, MD
Project Title: Lilly LY3202626 (BACE Inhibitor) NAVIGATE-AD Trial
Date: December 21, 2021 at 5:28 pm
Request ID: S1604
Aim 1: Safety/tolerability of LY3202626
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Investigator: Jeffrey M Zacks
Project Title: Improving everyday memory in healthy aging and early AD
Date: December 21, 2021 at 5:28 pm
Request ID: S2102
Aim 1: Test whether and how attention to event segmentation improves elders� memory for everyday activity at delays from minutes to weeks.
Aim 2: Test the hypothesis that effective event segmentation improves the resolution of elders� posterior/medial memory representations.
Aim 3: Test whether the mechanisms and consequences of segmentation improvement are maintained or impaired by early symptomatic Alzheimer�s disease.
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Investigator: Kevin Yarasheski
Project Title: Blood collection from individuals with APOE2/2, APOE2/3, APOE2/4, APOE3/3, APOE3/4 and APOE4/4 genotype to obtain plasma for the development and analytical validation of a plasma ApoE proteotype test
Date: December 21, 2021 at 5:28 pm
Request ID: S2103
Aim 1: The aim of this study is to collect plasma from individuals with APOE2/2, APOE2/3, APOE2/4, APOE3/3, APOE3/4 and APOE4/4 genotype to develop and analytically validate a plasma ApoE proteotype assay
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Investigator: ADİL ALPEREN ÇİFTCİ
Project Title: Deciphering Sounds Through Patterns of Vibration on the Skin
Date: December 21, 2021 at 5:28 pm
Request ID: S2104
Aim 1: the aim of representing environmental sounds such that very different sounds feel very different and very similar sounds feel very similar
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