The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Vimal Srivastava
Project Title: Therapeutic Efficacy Towards Plaque Reduction in 3D-Reprogrammed Human Alzheimer’s Disease Neurons
Date: June 12, 2025 at 4:08 pm
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Aim 1: We aim to develop a fibroblast-to-neuron transdifferentiation cell culture model for both healthy and AD-patient derived fibroblasts, under advisement by Dr. Andrew Yoo
Aim 2: We aim to evaluate our gene therapy towards reduction in amyloid plaque burden in 3D-reprogrammed neurons derived from Alzheimer’s Disease patients.
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Investigator: Gregory J. Brewer
Project Title: Redox State for AD Resilience
Date: June 4, 2025 at 5:52 pm
Request ID: T2505
Aim 1: Determine whether plasma and CSF redox states more accurately discriminate dementia than amyloid pathology. We hypothesize that a reductive redox profile is protective, while an oxidative shift contributes to dementia even with low amyloid burden.
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Investigator: Jonathan Kipnis
Project Title: Contribution of skull bone marrow-derived cells to Alzheimer’s disease
Date: May 15, 2025 at 12:31 pm
Request ID: T2504 Kipnis
Aim 1: To investigate the spatial distribution of brain-engrafting monocyte-derived macrophages in the brains of healthy and AD patients to determine if they are localized to sites of AD pathology.
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Investigator: Lien Nguyen
Project Title: Studying contribution of repeat expansions in Alzheimer’s disease
Date: April 17, 2025 at 10:21 am
Request ID: T2503
Aim 1: To test the hypothesis that repeat expansions within SINE/VNTR/Alu retrotransposable elements is associated with increased AD risk
Aim 2: To test the hypothesis that repeat expansions within SINE/VNTR/Alu retrotransposable elements contribute to AD via toxic mutant polymeric proteins
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Investigator: Gabriel Linares
Project Title: Biomarkers for synapse protection in Alzheimer’s Disease
Date: April 15, 2025 at 4:21 pm
Request ID: T2502
Aim 1: Evaluate levels of Ryk in biofluids from AD patients to determine if increased Ryk expression correlates with disease severity
Aim 2: Examine the association between Ryk expression and downstream AD pathologies
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Investigator: 2025-001
Project Title: Leveraging a large GRN family to identify resilience factors in Frontotemporal Lobar Degeneration: a genetic and proteomic approach
Date: March 13, 2025 at 8:14 am
Request ID: T2501
Aim 1: To identify single nucleotide variants that modify disease presentation in GRN mutation carriers.
Aim 2: To identify structural variants that alter disease presentation in GRN mutation carriers
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Investigator: Yi Zhang
Project Title: How would inclusion of “low tau” subgroups impact PBO progression rate?
Date: February 20, 2025 at 3:10 pm
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Aim 1: Identify “low-tau” screen-fails above the plasma p-Tau217 low-cutoff but below the tau PET low-cutoff
Aim 2: Match these individuals to comparable individuals in studies of treatment-naïve clinical progression
Aim 3: Leverage the clinical progression data to predict PBO progression rate of these populations
Aim 4: Compare trial power change when including different % of “low tau” subgroups
Investigator: Paul Kotzbauer
Project Title: Testing the Synucleinopenia Hypothesis – Are Brain tissue Levels of Soluble Alpha-Synuclein Decreased in Parkinson Disease?
Date: December 19, 2024 at 11:23 am
Request ID: T2419 Kotzbauer
Aim 1: Determine whether levels of soluble α-syn measured in five cortical regions are lower in PD participants compared to control participants.
Aim 2: Determine whether levels of soluble α-syn correlate with levels of insoluble α-syn and also whether each of these measures correlates with motor and cognitive symptoms of PD.
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Investigator: Nicolas Barthelemy
Project Title: Unraveling the link between tau modifications, neuroinflammation and tauopathies
Date: December 13, 2024 at 5:56 pm
Request ID: T2418 Barthelemy
Aim 1: To evaluate the effect of CNS PAD enzymes on soluble and insoluble tau citrullination in brain from participants with AD and non-AD tauopathies
Aim 2: To explore potential relationship existing between brain tau abnormal phosphorylation and citrullination and evaluate how these abnormalities associate with tau aggregation in AD and non-AD tauopathies
Aim 3: To evaluate the impact of 3R+4R tau pathology on the specificity of biomarker candidate of astrocytic tau pathology
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Investigator: Partha Dutta
Project Title: The role of microglia in cognitive impairment in patients with myocardial infarction
Date: October 15, 2024 at 10:21 am
Request ID: T2417 Dutta
Aim 1: To correlate mircoglial epigenetic modifiers with cognitive functin after myocardial infarction
Aim 2: To assess hippocampal microglia-neuron crosstalk in patients with myocardial infarction
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