The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Dr. Robert Vassar
Project Title: Molecular and cellular mechanisms of the UNC5C netrin receptor in Alzheimer’s disease pathogenesis
Date: April 23, 2024
Request ID: T2410
Aim 1: Determine the mechanism of UNC5C T835M-mediated cell death induced by AD-associated stressors in knockin mouse and patient hiPSC neurons in vitro.
Aim 2: Determine the mechanism of UNC5C T835M-mediated cell death induced by Aβ and Tau pathologies in vivo.
Aim 3: Identify the UNC5C T835M cell death pathway proteome induced by pathogenic Aβ and Tau using unbiased proteomics.
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Investigator: Moses Leavens
Project Title: Investigation of misfolded Superoxide Dismutase 1 and tau in Alzheimer’s disease
Date: March 25, 2024
Request ID: T2409 Leavens
Aim 1: Investigate misfolded SOD1 and tau seeding activities with Braak stage in sporadic Alzheimer’s disease
Aim 2: Determine SOD1 seeding activity in sporadic AD patient CSF
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Investigator: Soumya Mukherjee, Katherine Schwetye
Project Title: Development of biofluid biomarker for cerebral amyloid angiopathy (CAA)
Date: March 18, 2024
Request ID: T2408
Aim 1: Identify individuals with bio-fluid in the Knight ADRC Biobank database with confirmed postmortem neuropathological changes for cerebral amyloid angiopathy (CAA)
Aim 2: Compare the amyloid-beta concentrations in CAA patients with Alzheimer disease and controls in the biofluids (CSF and plasma) using IP-MS
Aim 3: Develop specific CSF and blood based biomarkers for CAA
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Investigator: John Sninsky
Project Title: Development of the cell-free messenger-RNA based biomarkers for Alzheimer’s disease
Date: February 19, 2024
Request ID: T2406
Aim 1: Validate the performance of the cf-mRNA-based AD diagnostic classifier using an independent validation cohort.
Aim 2: Develop a predictive biomarker for MCI progression to AD (progressor vs non-progressor).
Aim 3: Evaluate the disease specificity of the cf-mRNA-based AD diagnostic classifier using plasma of other neurodegenerative diseases.
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Investigator: Chengjie Xiong
Project Title: A pilot study to assess the mechanisms of linkages between Alzheimer Disease biomarkers and exposure to fine particulate matter
Date: February 19, 2024
Request ID: T2407
Aim 1: ~30 chemicals/metabolite biomarkers from the blood will be correlated with PM1, PM2.5, and PM 10 at baseline, and these same chemicals will also be associated with established AD biomarkers, including plasma AB42/AB40 and pTau217 (from C2N), CSF AB42/AB40, pTau181, and pTau217, and PET amyloid and t
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Investigator: Katherine Schwetye and Soumya Mukherjee
Project Title: Mass-spectroscopic characterization of N-terminal PTMs and isoform distribution of Aβ species in vascular deposits vs. parenchymal plaques
Date: February 1, 2024
Request ID: T2404
Aim 1: Determine the percentage of isomerization and isoform distribution at the N-terminus, and post-translational modifications of the amyloid-beta peptide in vessels using mass spectrometry (MS)
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Investigator: Iman beheshti
Project Title: Association between inflammation factors and brain aging in spectrum of AD
Date: January 27, 2024
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Aim 1: Using statistical and AI models to uncover the inflammation factors that faster brain aging in cognitively healthy, MCI and AD subjects with respect to sex.
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Investigator: Jonathan Kipnis
Project Title: Contribution of skull bone marrow-derived cells to Alzheimer’s disease
Date: January 26, 2024
Request ID: T2405
Aim 1: Assess a set of molecular markers, which we identified in engrafting myeloid cells in AD mouse model, in human tissues from AD and non-AD brains.
Aim 2: Correlate the expression of these molecular markers with AD pathology.
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Investigator: Sally Temple
Project Title: vascular and organoid modeling of neurodegenerative disease
Date: January 19, 2024
Request ID: T2403
Aim 1: examination of ELAVL4 immunostaining in cortical glutamatergic neurons in FTD-tau
Aim 2: Identify the RNA and protein interactome of ELAVL4 in FTD-tau
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Investigator: David Holtzman
Project Title: Understanding the progression of tau pathology in Alzheimer Disease by genetic, environmental, and pharmacological factors
Date: January 9, 2024
Request ID: T2402
Aim 1: Determine how MSA4A function in microglia impacts NP-tau seeding and spreading
Aim 2: Understand whether depletion of gut microbiota using broad-spectrum antibiotics impacts NP-tau sedding and spreading
Aim 3: Determine if next-generation passive immunization therapies to clear amyloid plaques and therapeutic lowering of APOE using antisense oligonucleotides lowers NP-tau seeding and spreading
Aim 4: Determine if T cell depletion impacts NP tau seeding and spreading