The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Marc Diamond
Project Title: Testing for tau aggregate seeding activity in CSF as a possible AD biomarker
Date: December 21, 2021 at 5:02 pm
Request ID: T1208
Aim 1: Test whether a novel tissue culture assay can detect tau aggregate seeds specifically in AD samples
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Investigator: Anne Fagan and Hideaki Bujo
Project Title: Soluble LR11 (sLR11) as a potential CSF biomarker of AD
Date: December 21, 2021 at 5:02 pm
Request ID: T1207
Aim 1: Test ability of CSF sLR11 to distinguish cognitively normal individuals from DAT
Aim 2: Investigation the relationship between sLR11 and Ab42
Aim 3: Future: utility of sLR11 as a prognostic biomarker of future cognitive decline in CDR 0
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Investigator: Carlos Cruchaga
Project Title: Identification of genetic variants associated with cerebrospinal fluid granulin levels (Amendment)
Date: December 21, 2021 at 5:02 pm
Request ID: T1209
Aim 1: To identify genetic variants associated with CSF GRN levels through a genome-wide association study
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Investigator: Dr. John Hardy
Project Title: Genome wide association studies (GWAS) for Frontotemporal-dementia (FTD).
Date: December 21, 2021 at 5:02 pm
Request ID: T1210
Aim 1: Identification of common variants associated with FTD
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Investigator: TERESA GOMEZ-ISLA
Project Title: Dissecting molecular mechanisms involved in human brain resilience to Alzheimer’s pathology
Date: December 21, 2021 at 5:02 pm
Request ID: T1228
Aim 1: Are some human brains resistant to AD pathology (amyloid plaques and neurofibrillary tangles)?
Aim 2: What are the neuroprotective mechanisms involved?
Aim 3: Is the Abeta/tau phenotype what determines structural damage and impaired cognition in AD?
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Investigator: Holly D. Soares
Project Title: Development of IVD CSF AB42 and Tau Assays
Date: December 21, 2021 at 5:02 pm
Request ID: T1227
Aim 1: Aim 1: To define normative ranges in cognitively normal individuals who have remained cognitively n
Aim 2: Aim 2: To define assay specific cutpoints for cognitively impaired individuals at risk of progressi
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Investigator: G. William Rebeck
Project Title: Early Effects of APOE genotype on brain function
Date: December 21, 2021 at 5:02 pm
Request ID: T1218-A
Aim 1: Identify CSF biomarkers of AD risk
Aim 2: Measure levels of neurotransmitters in CSF
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Investigator: John C. Morris/Jungsu Kim
Project Title: MicroRNA biomarkers for early detection of Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1226
Aim 1: Identification of cerebrospinal fluid miRNA biomarkers for early detection of AD
Aim 2: Identification of plasma miRNA biomarkers for early detection of AD
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Investigator: Carlos Cruchaga, Celeste Karch
Project Title: Identification of rare variants implicated on Alzheimer’s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1225
Aim 1: To identify genes deferentially expressed in AD brains compared to controls
Aim 2: To identify proteins with different levels in AD brains compared to controls
Aim 3: To identify genetic variants associated with gene expression
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Investigator: Alison Goate/Carlos Cruchaga
Project Title: Identification of rare variants implicated on Alzheimer’s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1224
Aim 1: Identification of rare variants implicated on Alzheimer’s Disease
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