The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Matthew Harms
Project Title: Tissue heterogeneity of the C9ORF72 expansion in carriers
Date: December 21, 2021 at 5:02 pm
Request ID: T1233
Aim 1: Characterize differences the C9 repeat expansion between tissue types (brain vs non-brain)
Aim 2: Characterize differences the C9 repeat expansion between brain regions
Aim 3: Correlate tissue expansion sizes with C9 expression levels
Aim 4: Correlate tissue expansion sizes with neuropathological features
Investigator: Berislav V. Zlokovic
Project Title: CSF BIOMARKERS OF BLOOD-BRAIN BARRIER BREAKDOWN IN COGNITIVELY NORMAL AND ALZHEIMER’S INDIVIDUALS
Date: December 21, 2021 at 5:02 pm
Request ID: T1234
Aim 1: TO DETERMINE THE EFFECTS OF APOE GENOTYPE ON CSF MARKERS OF BBB BREAKDOWN IN COGNITIVELY NORMAL
Aim 2: TO DETERMINE THE EFFECTS OF APOE GENOTYPE ON CSF MARKERS OF BBB BREAKDOWN IN MILD AND SEVERE AD
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Investigator: Nikolaos Robakis
Project Title: Correlation of microRNA and protein expression in AD brains
Date: December 21, 2021 at 5:02 pm
Request ID: T1229
Aim 1: Levels of neuronal microRNAs and target proteins, including PEA-15 and EphB2 in AD brains.
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Investigator: Berislav V Zlokovic
Project Title: Pericyte deficiency and blood-brain barrier breakdown in various Alzheimer’s disease APOE genotypes
Date: December 21, 2021 at 5:02 pm
Request ID: T1230
Aim 1: To determine the effects of APOE genotype on blood-brain barrier permeability in AD
Aim 2: To determine the effects of APOE genotype on pericyte coverage and number in AD
Aim 3: Investigate cell-specific distribution and levels of LRP-1 and MMP-9 in AD
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Investigator: Alison Goate
Project Title: Defining the mechanisms of AD pathogenesis in human IPSC-derived neurons
Date: December 21, 2021 at 5:02 pm
Request ID: T1301
Aim 1: To measure the influence of pathogenic FAD mutations on APP and tau metabolism in human neurons
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Investigator: Philip B. Verghese
Project Title: Amendment to “Apolipoprotein E Isoforms and Aβ Metabolism (T1005)”
Date: December 21, 2021 at 5:02 pm
Request ID: T1005-A
Aim 1: Characterize the CNS apoE isoform-associated proteome and lipidome in normal and AD subjects
Aim 2: Determine how lipids and proteins of apoE isoforms modulate apoE functions
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Investigator: Marc I. Diamond
Project Title: Characterizing tau aggregate species via structural mapping
Date: December 21, 2021 at 5:02 pm
Request ID: T1322
Aim 1: Cluster tauopathy patients in clinically meaningful ways via structural mapping of tau aggregates.
Aim 2: Determine if disease progression rates are influenced by tau aggregate protein structure.
Aim 3: Determine if tau aggregate protein structure is consistent between brain regions.
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Investigator: Joel Kramer
Project Title: Disease-free Aging Control Group for Tau Consortium Genetic Studies
Date: December 21, 2021 at 5:02 pm
Request ID: T1321
Aim 1: provide DNA from functionally normal controls without family history of neurodegenerative disease
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Investigator: David Holtzman
Project Title: : Synuclein seed detection in brains of patients with synucleinopathies
Date: December 21, 2021 at 5:02 pm
Request ID: T1319
Aim 1: Detect synuclein seeds in brain tissue of different synucleinopathies
Aim 2: Determine if there are unique conformers of synuclein in the different synucleinopathies
Aim 3: Determine if there is regional specificity of synuclein conformers
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Investigator: Sidney Strcikland
Project Title: Identification of a Plasmin-Resistant Fibrin Fragment as a Biomarker for Alzheimer’s disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1320
Aim 1: Determine a level of plasmin-resistant fibrin fragment in CSF from AD patients
Aim 2: The relationship between a level of Fibrin Fragment and pathological characteristics of AD patients
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