The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Denise Head
Project Title: Differential Effects of Stress on Brain Structure and Cognition in Healthy Older Adults
Date: December 21, 2021 at 5:28 pm
Request ID: S1308
Aim 1: Determine the differential influence of cumulative stress/HPA axis activity on brain regions
Aim 2: Determine the differential influence of cumulative stress/HPA axis activity on cognitive functions
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Investigator: Jo Ann Antenor-Dorsey
Project Title: Effect of Sleep on Aerobic Glycolysis and Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1310
Aim 1: Determine if sleep disruption is associated with changes in aerobic glycolysis in the default mode n
Aim 2: Determine if sleep disruption is associated A-beta plaque deposition in the default mode network
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Investigator: Randall Bateman
Project Title: Anti-Amyloid Treatment in Asymtomatic Alzheimer’s Disease (A4 Study)
Date: December 21, 2021 at 5:28 pm
Request ID: S1311
Aim 1: Test the hypothesis that solanezumab, administered as an IV infusion at a dose of 400mg every 4 weeks for 3 years, will slow cognitive decine as compared with placebo in subjects with preclincial AD
Aim 2: To test the hypothesis taht solanezumab will slow the decline of preceived function and performance of everyday activities, as compared to placebo
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Investigator: John Morris and Matthew Gabel
Project Title: Disclosure of Individual Research Results in Alzheimer’s Disease: Perceptions of At-Risk Asymptomatic Participants
Date: December 21, 2021 at 5:28 pm
Request ID: S1401
Aim 1: Educate an experimental group and assess perceptions of and interest in disclosure.
Aim 2: Examine responses as a function of potential modifying factors (e.g. age, political ideology).
Aim 3: Examine how study subjects compare with a nationally representative sample on the survey.
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Investigator: David Balota
Project Title: Cognitive Training in Prospective Memory
Date: December 21, 2021 at 5:28 pm
Request ID: S1402
Aim 1: whether explicit instruction leads to transfer of learning for prospective memory
Aim 2: what type of prospective memory training participants that is most effective for transfer
Aim 3: whether the same training works for a CDR .05 sample
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Investigator: Dave Balota
Project Title: Age Differences in Category Learning Strategies
Date: December 21, 2021 at 5:28 pm
Request ID: S1405
Aim 1: To determine whether individual differences in category learning strategies differ between younger and older adults.
Aim 2: To examine the relationship between the volume of brain regions and category learning strategies in healthy older adults.
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Investigator: Randall Bateman, Chihiro Sato
Project Title: Analysis of Tau Kinetics using Infusion of Stable Isotopes
Date: December 21, 2021 at 5:28 pm
Request ID: S1406
Aim 1: What is the Half Life of Tau in the Human Central Nervous System
Aim 2: Is CSF Tau increased due to over-production or under-clearance
Aim 3: Are Tau Kinetics altered in Alzheimer’s Disease
Aim 4: How much should Tau be modulated by drugs which Target Tau
Investigator: Catherine M. Roe
Project Title: Evaluating the feasibility of using a global positioning data acquisition system to assess driving safety and decline in older adults with and without preclinical Alzheimer disease.
Date: December 21, 2021 at 5:28 pm
Request ID: S1407
Aim 1: To examine the feasibility of, and to develop the methodology for, the use of GPDAS to capture everyday driving behavior.
Aim 2: To compare driving performance using GPDAS in 10 adults with preclinical AD and 10 adult without.
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Investigator: John Morris
Project Title: Antecedent Biomarkers for AD; The Adult Children Study
Date: December 21, 2021 at 5:28 pm
Request ID: S1501
Aim 1: In the cross-sectional arm of this study we will determine the relationship across subjects of well-established risk factors for, and biomarkers of AD to measurements of regional circulation and metabolism (blood flow, aerobic glycolysis as well as total glucose and oxygen metabolism
Aim 2: In the longitudinal arm of this study we will determine the relationship of changes in clinical assessments and biomarkers of AD to changes in regional circulation and metabolism.
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Investigator: Samantha Allison
Project Title: Developing a Spatial Navigation-Related Task for Detecting Preclinical AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1502
Aim 1: Assess the diagnostic accuracy of five spatial navigation-related tasks
Aim 2: Assess the reliability of five spatial navigation-related tasks
Aim 3: Assess the validity of five spatial navigation-related tasks
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