The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Tammie Benzinger
Project Title: F 18 T807 Tau PET Imaging of Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1307
Aim 1: Perform human in vivo tau imaging using F 18 T807 (aka 18F-AV1451) in 100 participants age 18 and ol
Aim 2: Develop quantitative analysis methods for F 18 T807 PET scans.
Aim 3: Correlate regional quantitative T807 binding potentials (BPs) with (a) progression of cognitive impa
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Investigator: David Carr
Project Title: Theraputic effects of intransasally-administered insulin in adults with aMCI or mild AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1306
Aim 1: To examine the effects of intranasally-administered insulin (INI) on cognition in aMCI and AD
Aim 2: To examine the effects of INI on entorhinal cortex and hippocampal atrophy in aMCI and AD
Aim 3: To examine the effects of INI on CSF biomarkers in aMCI and AD
Aim 4: Exam global measures of cognitive performance over 12 months of INI treatment compared to placebo
Investigator: David Van Essen
Project Title: Lifespan Pilot Supplement for WashU-UMinn Human Connectome Project (HCP) Consortium
Date: December 21, 2021 at 5:28 pm
Request ID: S1305
Aim 1: To determine what modifications of current HCP procedures are needed for older adults
Aim 2: To compare data acquired by modified HCP methods to data from previous studies in older adults
Aim 3: To estimate effect sizes to inform group sizes needed to demonstrate age differences in connectivity
Aim 4: To pilot behavioral phenotyping inolder adults using NIH Toolbox and other HCP measures
Investigator: B. Joy Snider
Project Title: Tests: The new age of dementia diagnosis
Date: December 21, 2021 at 5:28 pm
Request ID: S1204
Aim 1: Evaluate the impact of CSF biomarkers on clinician diagnosis
Aim 2: Evaluate the impact of CSF biomarkers on clinician confidence in diagnosis
Aim 3: Evaluate the impact of CSF biomarkers on clinician treatment plan
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Investigator: Nupur Ghoshal/ Clay Semenkovich
Project Title: Clinical and Biomarker Characterization of Inherited Frontotemporal Dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1303
Aim 1: A cohort of FTD caused by mutation in MAPT and GRN will be established, cognitively characterized, a
Aim 2: Use plasma and CSF to establish tau biomarker profiles that are unique to presymptomatic individuals
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Investigator: yvette Sheline
Project Title: Escitalopram Effects on CSF AB Total Concentration
Date: December 21, 2021 at 5:28 pm
Request ID: S1302
Aim 1: Compared to controls, subjects who get the 20mg/dayx2wks will have lower CSF concentration of A-beta
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Investigator: Dr. David Kaufman
Project Title: Behavioral and Electrophysiological Correlates of Attentional Control Deficits in Early-Stage AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1301
Aim 1: Very mild AD will lead to a reduction in the maintenance of task context
Aim 2: Very mild AD will lead to altered neural activity associated with conflict processing
Aim 3: The aforementioned behavioral and electrophysiological correlates will be positively correlated
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Investigator: Andrea Denny
Project Title: Ethnic differences in willingness to assent to brain donation
Date: December 21, 2021 at 5:28 pm
Request ID: S1208
Aim 1: What factors among ethnically diverse research participants influence brain donation?
Aim 2: What are differences among elders in ethnic groups in the likelihood to assent to brain donation?
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Investigator: Cathy Roe, PhD
Project Title: Driving Performance in Preclinical Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1207
Aim 1: Is preclinical AD a risk factor for impaired driving both at baseline and at longitudinal follow-up?
Aim 2: Are cognitive reserve factors associated with driving performance at baseline and follow-up?
Aim 3: Are navigational impairments risk factors for impaired driving at baseline and folllow-up?
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Investigator: B, Joy Snider (WU site)
Project Title: Protocol 221AD301 A phase 3 Multicenter, RCT to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer�s Disease (ENGAGE Study)
Date: December 21, 2021 at 5:28 pm
Request ID: S1607
Aim 1: Evaluate the efficacy of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the CDR-SB score as compared with placebo in subjects with early AD.
Aim 2: Evaluate the efficacy of aducanumab on MMSE, ADAS-Cog13, ADCS-ADL
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