The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Mitchell Sommers
Project Title: False hearing and cognitive control in DAT
Date: December 21, 2021 at 5:28 pm
Request ID: S1304
Aim 1: Determine if impaired cognitive control in DAT affects response bias
Aim 2: Determine if individuals with DAT rely more on context for speech perception
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Investigator: Nupur Ghoshal/ Clay Semenkovich
Project Title: Clinical and Biomarker Characterization of Inherited Frontotemporal Dementia
Date: December 21, 2021 at 5:28 pm
Request ID: S1303
Aim 1: A cohort of FTD caused by mutation in MAPT and GRN will be established, cognitively characterized, a
Aim 2: Use plasma and CSF to establish tau biomarker profiles that are unique to presymptomatic individuals
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Investigator: yvette Sheline
Project Title: Escitalopram Effects on CSF AB Total Concentration
Date: December 21, 2021 at 5:28 pm
Request ID: S1302
Aim 1: Compared to controls, subjects who get the 20mg/dayx2wks will have lower CSF concentration of A-beta
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Investigator: Dr. David Kaufman
Project Title: Behavioral and Electrophysiological Correlates of Attentional Control Deficits in Early-Stage AD
Date: December 21, 2021 at 5:28 pm
Request ID: S1301
Aim 1: Very mild AD will lead to a reduction in the maintenance of task context
Aim 2: Very mild AD will lead to altered neural activity associated with conflict processing
Aim 3: The aforementioned behavioral and electrophysiological correlates will be positively correlated
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Investigator: Andrea Denny
Project Title: Ethnic differences in willingness to assent to brain donation
Date: December 21, 2021 at 5:28 pm
Request ID: S1208
Aim 1: What factors among ethnically diverse research participants influence brain donation?
Aim 2: What are differences among elders in ethnic groups in the likelihood to assent to brain donation?
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Investigator: Cathy Roe, PhD
Project Title: Driving Performance in Preclinical Alzheimer’s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1207
Aim 1: Is preclinical AD a risk factor for impaired driving both at baseline and at longitudinal follow-up?
Aim 2: Are cognitive reserve factors associated with driving performance at baseline and follow-up?
Aim 3: Are navigational impairments risk factors for impaired driving at baseline and folllow-up?
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Investigator: Randall Bateman
Project Title: DIAN-TU-001
Date: December 21, 2021 at 5:28 pm
Request ID: S1206
Aim 1: test safety and efficacy of two disease-modifying treatments for dominantly inherited AD
Aim 2: test effects of treatments on biomarkers (CSF and imaging) in dominantly inherited AD
Aim 3: test cognitive measures in presymptomatic individuals in dominantly inherited AD
Aim 4: compare two amyloid imaging agents in dominantly inherited AD
Investigator: Eric McDade
Project Title: Cerebrovascular Reactivity in the Presence of Cerebral Amyloid and Cerebrovascular Disease:
Date: December 21, 2021 at 5:28 pm
Request ID: S1608
Aim 1: To explore the impact of cerebral amyloid on cerebrovascular reactivity
Aim 2: To explore the impact of age and vascular related comorbidities in the relationship of cerebrovascular reactivity and cerebral amyloid
Aim 3: To explore the the impact of cerebrovascular reactivity as a moderator of amyloid related cognitive impairment
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Investigator: Jonathan Peelle & Mitch Sommers
Project Title: Hearing and speech in Alzheimer�s Disease
Date: December 21, 2021 at 5:28 pm
Request ID: S1805
Aim 1: Validate a short hearing test using test-retest reliability in participants with CDRs of 0, 0.5, and 1
Aim 2: Conduct exploratory analyses between hearing, cognitive, and imaging data to support future grant applications
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Investigator: Beau M. Ances, MD, PhD
Project Title: Allzheimer Disease Neuroimaging Initiative 3 (ADNI3)
Date: December 21, 2021 at 5:28 pm
Request ID: S1606
Aim 1: To discover, optimize, standardize, and validate clinical trial measures and biomarkers used in AD research
Aim 2: To capture rates of decline on cognitive, global and functional tests and the rate of conversion to MCI or dementia due to AD.
Aim 3: Determine the longitudinal extent and rate of amyloid and tau deposition in PET Scans and longitudinal change of cerebral tau correlated and compared with other changes in cognition and biomarkers
Aim 4: Determine which clinical, cognitive and biomarker and imaging capture detection of treatment effects and measure cognitive decline for all groups with a focus on biomarkers and Tau.