The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Gilbert Gallardo
Project Title: Determining the contribution of reactive astrocytes on amyloid-induced tauopathy
Date: February 14, 2022 at 5:26 pm
Request ID: T2205
Aim 1: The purpose of this tissue request is to investigate the contribution of reactive astrocytes on tau seeding and spreading in the presence of amyloid β plaques.
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Investigator: David Holtzman
Project Title: T cell surveillance and tau pathology in Alzheimer’s disease and primary tauopathies
Date: February 7, 2022 at 10:20 am
Request ID: T2202
Aim 1: Assess the relationship between T cell population and p-tau at different Braak stages of AD
Aim 2: Assess the relationship between T cell population and p-tau in primary tauopathies
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Investigator: Miles Berger
Project Title: APOE4 dependent effects on the Complement Pathway in human CSF from across the full adult lifespan
Date: January 24, 2022 at 10:12 am
Request ID: T2201
Aim 1: Determine the effect of APOE4 copy number on complement protein levels in the CSF in neurologically normal individuals across the adult life span (age 18-80)
Aim 2: Determine the effect of APOE4 copy number on complement pathway activation in the CSF in neurologically normal individuals across the adult life span (age 18-80)
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Investigator: Sun, Grace
Project Title: Immunohistochemistry identification of cPLA2 and COXII in control and AD brain
Date: December 21, 2021 at 5:02 pm
Request ID: T9901
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Investigator: Wu, Jane
Project Title: The Role of Alternative Splicing in Neurodegeneration
Date: December 21, 2021 at 5:02 pm
Request ID: T0012
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Investigator: Sun, Grace
Project Title: Expression of metabotropic glutamate receptor 5 and 7 mRNAs in AD brain
Date: December 21, 2021 at 5:02 pm
Request ID: T9902
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Investigator: Galvin, James E.
Project Title: Gene Expression Profile of Inclusion Bearing Neurons
Date: December 21, 2021 at 5:02 pm
Request ID: T0013
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Investigator: Kido, Daniel
Project Title: Microhemorrrhages in the Elderly
Date: December 21, 2021 at 5:02 pm
Request ID: T9903
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Investigator: Finch, Caleb E. (Tuck)
Project Title: Characterization of complement factors and their association with A-beta deposits
Date: December 21, 2021 at 5:02 pm
Request ID: T9912
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Investigator: Smith, Mark A.
Project Title: Oxidative Damage via Mitochondria-derived Free Radical Accumulation
Date: December 21, 2021 at 5:02 pm
Request ID: T9908
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