The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Project Title: Biomarkers and Rates of Progression in Dementia (Bio-RaPID)
Date: June 2, 2023
Request ID: T2307
Aim 1: Define the “cellular contributors” to RPD, addressing the key question of what makes patients vulnerable to rapidly progressive dementia
Investigator: Qing Wang
Project Title: Association of CSF sTREM2 and plasma GFAP with an MRI measure of neuroinflammation
Date: April 19, 2023
Request ID: T2306
Aim 1: Compare DBSI neuroinflammation index to in vivo CSF and plasma inflammation biomarkers (sTREM2 and GFAP) in the Knight ADRC cohorts
Investigator: Andrew Kraft / Evan Macosko
Project Title: Cellular mechanics of white matter disease
Date: April 15, 2023
Request ID: T2304
Aim 1: Determine spatial heterogeneity in healthy WM cell type composition and gene expression.
Aim 2: Identify the selective cellular vulnerabilities that define cerebral small vessel disease- and Alzheimer disease-related WMD
Investigator: Jonathan Kipnis
Project Title: Continuous perivascular space allows brain macromolecules efflux to the dura mater
Date: April 15, 2023
Request ID: T2305
Aim 1: Define arteriovenous overlaps in the human leptomeninges.
Aim 2: Determine the ultrastructure of arteriovenous overlaps of non-dementia and Alzheimer’s disease patients.
Investigator: Randall Bateman
Project Title: Evaluation of peripheral apoE protein levels as a function of CNS amyloidosis development in a Knight ADRC cohort.
Date: April 13, 2023
Request ID: T2303
Aim 1: Assess the timing of changes in peripheral apoE protein levels as a function of CNS amyloidosis development.
Investigator: Hongyu An
Project Title: Neuroinflammation in Cerebral Small Vessel Disease using PET/MR Imaging
Date: March 14, 2023
Request ID: T2302
Aim 1: Determine if S1PR1 expression increases and colocalizes with microglia and astrocytes in post-mortem brain specimens from deceased patients with underlying CSVD.
Aim 2: Determine if neuroinflammation measured by 11C-CS1P1 uptake is independently associated with CSVD structural endpoints using in vivo PET/MR imaging.
Investigator: Zachary McEachin
Project Title: Assessment of cryptic exons in TDP-43 proteinopathies
Date: February 14, 2023
Request ID: T2301
Aim 1: Determine the abundance of cryptic exons across FTLD-TDP subtypes
Aim 2: Determine the proteomic signatures associated with distinct TDP-43 subtypes
Project Title: Tissue request T1225. Second Amendment Brain RNA levels, protein levels and Alzheimer’s Disease: deep molecular profiling
Date: February 12, 2023
Request ID: T1225-B
Aim 1: Identification and Characterization of Cell-Specific Transposable Elements Implicated on Alzheimer Disease and Healthy Aging
Aim 2: To generate neuron and microglia specific ATAC-seq, CAGE-seq, DNA methylation and long-reads RNA-seq
Investigator: A/Prof Matthew Pase
Project Title: Plasma inflammatory biomarkers for the diagnosis of dementia subtypes
Date: February 8, 2023
Request ID: T2217-A
Aim 1: To determine the diagnostic accuracy of selected blood neuroinflammatory biomarkers
Aim 2: To determine if blood biomarkers of neuroinflammation correlate with established neurodegenerative disease biomarkers
Investigator: Chengjie Xiong
Project Title: R01 Cross Sectional and Longitudinal Racial Disparity in Molecular Biomarkers of AD
Date: November 25, 2022
Request ID: T2219
Aim 1: To implement a central and standardized processing protocol for retrospectively and prospectively collected plasma samples and a harmonized assessment protocol of SDOH across the sites, and to determine cross-sectional and longitudinal racial differences in plasma amyloid and pTau biomarkers.
Aim 2: To determine racial differences in the correlations of plasma biomarkers with CSF and imaging biomarkers, as well as concurrent and future clinical and cognitive outcomes.
Aim 3: To assess racial differences in plasma NfL and GFAP, and whether the differences are modified by risk factors for vascular disease: MRI white matter hyperintensities (WMH), BMI, and HbA1c.