The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Chengjie Xiong
Project Title: A pilot study to assess the mechanisms of linkages between Alzheimer Disease biomarkers and exposure to fine particulate matter
Date: [208]
Request ID: T2407
Aim 1: ~30 chemicals/metabolite biomarkers from the blood will be correlated with PM1, PM2.5, and PM 10 at baseline, and these same chemicals will also be associated with established AD biomarkers, including plasma AB42/AB40 and pTau217 (from C2N), CSF AB42/AB40, pTau181, and pTau217, and PET amyloid and t
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Investigator: Soumya Mukherjee, Katherine Schwetye
Project Title: Development of biofluid biomarker for cerebral amyloid angiopathy (CAA)
Date: [208]
Request ID: T2408
Aim 1: Identify individuals with bio-fluid in the Knight ADRC Biobank database with confirmed postmortem neuropathological changes for cerebral amyloid angiopathy (CAA)
Aim 2: Compare the amyloid-beta concentrations in CAA patients with Alzheimer disease and controls in the biofluids (CSF and plasma) using IP-MS
Aim 3: Develop specific CSF and blood based biomarkers for CAA
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Investigator: Moses Leavens
Project Title: Investigation of misfolded Superoxide Dismutase 1 and tau in Alzheimer’s disease
Date: [208]
Request ID: T2409 Leavens
Aim 1: Investigate misfolded SOD1 and tau seeding activities with Braak stage in sporadic Alzheimer’s disease
Aim 2: Determine SOD1 seeding activity in sporadic AD patient CSF
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Investigator: Dr. Robert Vassar
Project Title: Molecular and cellular mechanisms of the UNC5C netrin receptor in Alzheimer’s disease pathogenesis
Date: [208]
Request ID: T2410
Aim 1: Determine the mechanism of UNC5C T835M-mediated cell death induced by AD-associated stressors in knockin mouse and patient hiPSC neurons in vitro.
Aim 2: Determine the mechanism of UNC5C T835M-mediated cell death induced by Aβ and Tau pathologies in vivo.
Aim 3: Identify the UNC5C T835M cell death pathway proteome induced by pathogenic Aβ and Tau using unbiased proteomics.
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Investigator: Holtzman
Project Title: Using CO-detection by inDEXing (CODEX) multiplexed tissue imaging to assess immune and glial cell profiles in AD brain tissue
Date: [208]
Request ID: T2411
Aim 1: Perform pilot staining of AD and non-AD brain sections for proof-of-feasibility
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Investigator: Kanekiyo, Ulrich
Project Title: Lipid signature in cerebrospinal fluid predicting the risk for cognitive impairment in the elderly
Date: [208]
Request ID: T2412
Aim 1: Assess lipiomic profile in CSF using shotgun lipidomic analysis
Aim 2: Correlate lipidomic species with AD fluid biomarkers and cognitive status
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