Search Existing Tissue Requests

The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.


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Investigator: Khairul Ansari

Project Title: Evaluation of the binding of hyperphosphorylayted Tau to normal tau as a biomarker for Alzheimer’s disease pathology and related Tauopathies in the Knight ADRC cohort

Date: December 22, 2023

Request ID: T2321

Aim 1: We now propose to run a small set of well-characterized samples from the Knight ADRC (n=40) described in the Cohort Selection Section to replicate the results of the pilot study

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Investigator: Jin-Moo Lee, Carlos Cruchaga and Manu Goyal

Project Title: Unraveling WMH Mechanisms in VCID with Imaging, Novel Multi-omics, and Open Data (UNWIND)

Date: December 22, 2023

Request ID: T2320 Goyal

Aim 1: Define cellular and molecular pathways involved in white matter disease and their relationship to CAA, arteriolosclerosis, and AD pathology, using single cell and spatial transcriptomics in post-mortem human brain tissue.

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Investigator: Carlos Cruchaga

Project Title: CSF and plasma metabolomics characterization of AD and ADRD

Date: December 16, 2023

Request ID: T2318

Aim 1: Identification of metabolomics signatures and new prediction models for AD

Aim 2: Identify potential causal and druggable metabolites by using metabolomics-QTL and Mendelian randomization, colocalization, and PWAS approaches

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Investigator: Carlos Cruchaga

Project Title: Large Scale plasma proteomics of Alzheimer’s disease to identify novel biomarkers and causal targets

Date: December 16, 2023

Request ID: T2319

Aim 1: Identify plasma proteomic signatures and new prediction models for AD

Aim 2: Identify potential causal and druggable proteins by using pQTL and Mendelian randomization, colocalization, and PWAS approaches

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Investigator: Aaron Ring

Project Title: Decoding the Autoantibody ‘Reactome’ in Alzheimer’s Disease

Date: December 15, 2023

Request ID: T2316

Aim 1: Conduct an autoantibody-wide association study of Alzheimer’s Disease patients and matched controls to identify autoantibody responses that modify Alzheimer’s Disease risk and severity.

Aim 2: Evaluate the function and impact of Alzheimer’s Disease risk- or severity-modifying autoantibodies

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Investigator: Takahisa Kanekiyo, David Holtzman, Alison Goate

Project Title: Determine apoE isoform-dependent changes in composition of apoE lipoprotein particles in human CSF

Date: December 14, 2023

Request ID: T2317

Aim 1: Purify apoE particles from human CSF samples using antibody-based pull-down assay.

Aim 2: Assess the apoE particle size distribution with human CSF samples.

Aim 3: Detect the apoE particles associated proteins and lipids by proteomics and lipidomics profiling.

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Investigator: Robert Bucelli

Project Title: Reference range for CSF neurofilament light

Date: November 10, 2023

Request ID: T2314

Aim 1: Generating a reference range for CSF NfL within the clinical NM Lab using our Simoa HD-X analyzer. Samples will be run on the Quanterix HD-X analyzer using the Simoa® NF-Light v2 Advantage Kit. Data from three datasets will be combined to develop a reference range.

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Investigator: Carlos Cruchaga

Project Title: Unbiased proteomic analyses and novel prediction models

Date: November 10, 2023

Request ID: T2315

Aim 1: To generate proteomic data using the Alamar platform

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Investigator: Dr. Gilbert Gallardo

Project Title: Evaluation of CSF levels of Glutamine in Knight ADRC cohort

Date: October 17, 2023

Request ID: t2313

Aim 1: We proposed to examine the glutamine levels in the CSF collected from AD humans with dementia.

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Investigator: Zongtao Tom Lin

Project Title: Transforming Post-translational Arginylation into Targeted Tau Degradation Against Alzheimer’s Disease

Date: September 21, 2023

Request ID: T2312

Aim 1: Identify arginylation substrates in AD brains using activity-based arginylome profiling (ABAP).

Aim 2: Establish targeted tau degradation via ATE1 recruitment using FKBP-Halo system.

Aim 3: Develop ArgTACs for targeted tau degradation.

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