The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Takahisa Kanekiyo, David Holtzman, Alison Goate
Project Title: Determine apoE isoform-dependent changes in composition of apoE lipoprotein particles in human CSF
Date: December 14, 2023 at 5:00 pm
Request ID: T2317
Aim 1: Purify apoE particles from human CSF samples using antibody-based pull-down assay.
Aim 2: Assess the apoE particle size distribution with human CSF samples.
Aim 3: Detect the apoE particles associated proteins and lipids by proteomics and lipidomics profiling.
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Investigator: Carlos Cruchaga
Project Title: Unbiased proteomic analyses and novel prediction models
Date: November 10, 2023 at 12:05 pm
Request ID: T2315
Aim 1: To generate proteomic data using the Alamar platform
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Investigator: Robert Bucelli
Project Title: Reference range for CSF neurofilament light
Date: November 10, 2023 at 6:20 am
Request ID: T2314
Aim 1: Generating a reference range for CSF NfL within the clinical NM Lab using our Simoa HD-X analyzer. Samples will be run on the Quanterix HD-X analyzer using the Simoa® NF-Light v2 Advantage Kit. Data from three datasets will be combined to develop a reference range.
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Investigator: Dr. Gilbert Gallardo
Project Title: Evaluation of CSF levels of Glutamine in Knight ADRC cohort
Date: October 18, 2023 at 5:55 pm
Request ID: t2313
Aim 1: We proposed to examine the glutamine levels in the CSF collected from AD humans with dementia.
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Investigator: Zongtao Tom Lin
Project Title: Transforming Post-translational Arginylation into Targeted Tau Degradation Against Alzheimer’s Disease
Date: September 21, 2023 at 2:52 pm
Request ID: T2312
Aim 1: Identify arginylation substrates in AD brains using activity-based arginylome profiling (ABAP).
Aim 2: Establish targeted tau degradation via ATE1 recruitment using FKBP-Halo system.
Aim 3: Develop ArgTACs for targeted tau degradation.
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Investigator: Rawan Tarawneh/Carlos Cruchaga
Project Title: Endothelial Markers in AD
Date: September 17, 2023 at 12:59 pm
Request ID: T2311
Aim 1: Examine diagnostic and prognostic value of endothelial injury markers across different stages of AD
Aim 2: Evaluate relationship of endothelial injury to fluid and imaging markers of AD pathology and neurodegeneration
Aim 3: Characterize the contribution of endothelial injury to cognitive decline in preclinical and early symptomatic AD
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Investigator: gregory wu
Project Title: MOG antibodies in neurodegenerative diseases
Date: July 19, 2023 at 6:28 pm
Request ID: T2310
Aim 1: Determine the prevalence and titer of circulating MOG antibodies in patients with AD
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Investigator: Carlos Cruchaga
Project Title: Large scale gene discovery for neurological traits
Date: July 10, 2023 at 1:22 pm
Request ID: T2309
Aim 1: To generate WES for all the Knight-ADRC samples
Aim 2: To identify variants and genes associated with AD and ADRD
Aim 3: To determine the genetic overlap between AD, PD and other neurological traits
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Investigator: David Holtzman
Project Title: Evaluating the ability of gut microbiota to promote neuroinflammation and tau pathology
Date: June 8, 2023 at 3:49 pm
Request ID: T2308
Aim 1: Determine how the human AD microbiome impacts tau pathology, neuroinflammation, and neurodegeneration in a germ-free model of tau-mediated neurodegeneration
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Investigator: Day
Project Title: Biomarkers and Rates of Progression in Dementia (Bio-RaPID)
Date: June 2, 2023 at 12:15 pm
Request ID: T2307
Aim 1: Define the “cellular contributors” to RPD, addressing the key question of what makes patients vulnerable to rapidly progressive dementia
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