The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Carlos Cruchaga
Project Title: Single cell and spatial transcriptomics of Alzheimer�s Disease brains
Date: [208]
Request ID: T2110
Aim 1: Aim 1: To study the cell type-specific transcriptomic changes in AD brains
Aim 2: Aim 2: To perform spatial transcriptomic analyses.
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Investigator: Wesley Horton
Project Title: Inflammatory Markers for Early Detection and Subtyping of Neurodegenerative and Mood Disorders Tissue Request to Washington University ADRC
Date: [208]
Request ID: T2109
Aim 1: Determine the relationship of inflammatory markers in CSF and Plasma to clinical observations [Biomarker Signature Development]
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Investigator: Souvik Modi
Project Title: DNA nanosensor mediated two-ion mapping (2-IM) of Lysosomes as assessment diagnostics for Alzheimer�s disease
Date: [208]
Request ID: T2108
Aim 1: Baseline a reference range of lysosomal 2-IM profiles in healthy individuals across a well characterized sample set
Aim 2: Establish the diagnostic accuracy of our candidate biomarkers through analysis of a large-scale and well-characterized 2-IM dataset from lysosomes of patients with AD
Aim 3: Benchmark the sensitivity and diagnostic accuracy of our candidate biomarkers across the modalities of blood cells vs. skin fibroblasts
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Investigator: Yuchao Chen
Project Title: Identify and Validate an Extracellular Vesicle-based Diagnostic Signature for Alzheimer’s Disease
Date: [208]
Request ID: T2107
Aim 1: Identify a neuron-derived extracellular vesicle-based diagnostic signature for AD
Aim 2: Explore the pathologic mechanisms as well as new therapeutic targets
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Investigator: Oleg Butovsky
Project Title: Human validation of mouse studies related to distinct microglial signatures in APOE3 vs APOE4 AD carriers
Date: [208]
Request ID: T2106
Aim 1: Validate the effects of APOE variants in APPPS1-APOE4-KI vs in APPPS1-APOE3-KI mice in Microglia-Neutrophil interactions in Ab-plaques human AD brain expressing APOE variants
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Investigator: Carolina Soriano-Tarraga
Project Title: DNA methylation in Alzheimer�s disease
Date: [208]
Request ID: T2105
Aim 1: To identify Differentially Methylated Positions (DMP) in peripheral blood DNA of Alzheimer’s disease and Neuropathfree controls. Longitudinal analysis.
Aim 2: To study the Differentially Methylated Positions in early/late stages of Alzheimer’s disease.
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Investigator: Dr. Yehia Mechref
Project Title: LCMS analysis of serum glycans of Alzheimer’s Disease for diagnostic applications
Date: [208]
Request ID: T2103
Aim 1: This project aims to identify diagnostic serum glycan biomarkers for Alzheimer�s Disease
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Investigator: Chihiro Sato
Project Title: Tau kinetics in neuronal models with human brain Amyloid beta
Date: [208]
Request ID: T2104
Aim 1: Measure tau kinetics in neuronal model in the presence of human brain amyloid
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Investigator: Dianne Langford
Project Title: Biomarkers to detect risk for disease, predict outcome and prevent impaired clearance of waste from the brain
Date: [208]
Request ID: T2102
Aim 1: Determine if the (GT(n) repeat polymorphism of the NEFL gene is associated with with progressive cognitive impairment in AD
Aim 2: Determine if levels of NFL in blood associate with NEFL GT(n) repeats.
Aim 3: Determine of SNPS in the aquaporin 4 gene associate with greater brain levels of Tau and Abeta in blood and brain
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Investigator: Sharlee Climer
Project Title: Robust Alzheimer Disease Plasma-Based Diagnostic Tool that Cuts Across Ancestral Lines and COVID-19 Impacts
Date: [208]
Request ID: T2101
Aim 1: Generate genomics, proteomics, metabolomics, and lipidomics data for AD cases and controls, including African American volunteers, from plasma samples drawn prior to and following the COVID-19 pandemic.
Aim 2: Use a multi-pronged approach to identify high-dimensional biomarker signatures that can identify AD-associated interaction networks within and among the -omics data and create a plasma-based diagnostic tool.
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