Search Existing Tissue Requests

The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.


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Investigator: Carlos Cruchaga

Project Title: Single cell and spatial transcriptomics of Alzheimer�s Disease brains

Date: [208]

Request ID: T2110

Aim 1: Aim 1: To study the cell type-specific transcriptomic changes in AD brains

Aim 2: Aim 2: To perform spatial transcriptomic analyses.

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Investigator: Wesley Horton

Project Title: Inflammatory Markers for Early Detection and Subtyping of Neurodegenerative and Mood Disorders Tissue Request to Washington University ADRC

Date: [208]

Request ID: T2109

Aim 1: Determine the relationship of inflammatory markers in CSF and Plasma to clinical observations [Biomarker Signature Development]

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Investigator: Souvik Modi

Project Title: DNA nanosensor mediated two-ion mapping (2-IM) of Lysosomes as assessment diagnostics for Alzheimer�s disease

Date: [208]

Request ID: T2108

Aim 1: Baseline a reference range of lysosomal 2-IM profiles in healthy individuals across a well characterized sample set

Aim 2: Establish the diagnostic accuracy of our candidate biomarkers through analysis of a large-scale and well-characterized 2-IM dataset from lysosomes of patients with AD

Aim 3: Benchmark the sensitivity and diagnostic accuracy of our candidate biomarkers across the modalities of blood cells vs. skin fibroblasts

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Investigator: Yuchao Chen

Project Title: Identify and Validate an Extracellular Vesicle-based Diagnostic Signature for Alzheimer’s Disease

Date: [208]

Request ID: T2107

Aim 1: Identify a neuron-derived extracellular vesicle-based diagnostic signature for AD

Aim 2: Explore the pathologic mechanisms as well as new therapeutic targets

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Investigator: Oleg Butovsky

Project Title: Human validation of mouse studies related to distinct microglial signatures in APOE3 vs APOE4 AD carriers

Date: [208]

Request ID: T2106

Aim 1: Validate the effects of APOE variants in APPPS1-APOE4-KI vs in APPPS1-APOE3-KI mice in Microglia-Neutrophil interactions in Ab-plaques human AD brain expressing APOE variants

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Investigator: Carolina Soriano-Tarraga

Project Title: DNA methylation in Alzheimer�s disease

Date: [208]

Request ID: T2105

Aim 1: To identify Differentially Methylated Positions (DMP) in peripheral blood DNA of Alzheimer’s disease and Neuropathfree controls. Longitudinal analysis.

Aim 2: To study the Differentially Methylated Positions in early/late stages of Alzheimer’s disease.

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Investigator: Dr. Yehia Mechref

Project Title: LCMS analysis of serum glycans of Alzheimer’s Disease for diagnostic applications

Date: [208]

Request ID: T2103

Aim 1: This project aims to identify diagnostic serum glycan biomarkers for Alzheimer�s Disease

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Investigator: Chihiro Sato

Project Title: Tau kinetics in neuronal models with human brain Amyloid beta

Date: [208]

Request ID: T2104

Aim 1: Measure tau kinetics in neuronal model in the presence of human brain amyloid

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Investigator: Dianne Langford

Project Title: Biomarkers to detect risk for disease, predict outcome and prevent impaired clearance of waste from the brain

Date: [208]

Request ID: T2102

Aim 1: Determine if the (GT(n) repeat polymorphism of the NEFL gene is associated with with progressive cognitive impairment in AD

Aim 2: Determine if levels of NFL in blood associate with NEFL GT(n) repeats.

Aim 3: Determine of SNPS in the aquaporin 4 gene associate with greater brain levels of Tau and Abeta in blood and brain

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Investigator: Sharlee Climer

Project Title: Robust Alzheimer Disease Plasma-Based Diagnostic Tool that Cuts Across Ancestral Lines and COVID-19 Impacts

Date: [208]

Request ID: T2101

Aim 1: Generate genomics, proteomics, metabolomics, and lipidomics data for AD cases and controls, including African American volunteers, from plasma samples drawn prior to and following the COVID-19 pandemic.

Aim 2: Use a multi-pronged approach to identify high-dimensional biomarker signatures that can identify AD-associated interaction networks within and among the -omics data and create a plasma-based diagnostic tool.

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