The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Andrew Yoo
Project Title: Modeling Alzheimer�s disease with human neurons generated by direct conversion (reprogramming) of patient fibroblasts
Date: [208]
Request ID: T1912
Aim 1: Direct conversion of dermal fibroblasts from the patients of sporadic AD to neurons
Aim 2: Modeling sporadic AD via directly converted patient neurons
Aim 3: Development of 3D culture system for modeling AD
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Investigator: Paul Worley
Project Title: NPTX2 and sleep parameters in aging and AD
Date: [208]
Request ID: T1911
Aim 1: measure NPTX2 in CSF from subjects described in Lucey, B. Sci Transl Med 11 (2019)
Aim 2: assess correlations with EEG measures of rhythmicity
Aim 3: test association with markers of AD pathology
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Investigator: Jonathan Kipnis
Project Title: Infection of meninges and brain by Herpesviridae: is there a link with dementia severity?
Date: [208]
Request ID: T1905
Aim 1: Test for the presence of human herpes virus in the meninges and brain tissue of patients diagnosed with Alzheimer�s disease, Vascular dementia or non-demented age-matched controls
Aim 2: Test the hypothesis that increased viral load in the meninges of dementia
Aim 3: Test the hypothesis that increased viral load in the meninges, but not in the brain, is associated with the severity of AD and/or Vascular dementia
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Investigator: Andreas Ballis
Project Title: Validation of U-p53 blood biomarker for Alzheimer’s disease
Date: [208]
Request ID: T1910
Aim 1: U-p53 Performance evaluation and cut-off determination in a cross sectional study of older individuals (>60 years of age) with and without amyloidosis with normal cognition (CDR0) very mild dementia (CDR0.5) and mild dementia (CDR1).
Aim 2: U-p53 Cut-off and performance Validation
Aim 3: U-p53 performance in predicting clinical progression.
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Investigator: Erik Musiek
Project Title: Examining the impact of circadian disruption on tau seeding and spreading in a mouse model of Alzheimer�s Disease
Date: [208]
Request ID: T1907
Aim 1: Examine the effect of central vs. peripheral circadian clock disruption on plaque-related tau seeding/spreading
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Investigator: Colonna
Project Title: digital spatial profiling (DSP) of AD brains
Date: [208]
Request ID: T1908
Aim 1: To image glia in AD brains compared to controls using a multiple antibodies
Aim 2: To image key activation markers of glia in AD brains compared to controls
Aim 3: To image activated microglia in brains of AD versus AD carrying TREM2 mutations
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Investigator: Timothy Miller
Project Title: ASO-Mediated Approach to Increase Progranulin Protein
Date: [208]
Request ID: T1909
Aim 1: Measure baseline progranulin protein levels in human GRN patient fibroblasts.
Aim 2: Investigate progranulin protein levels after treatment with progranulin-targeting antisense oligonucleotide.
Aim 3: Assay TDP-43 phosphorylation in human GRN patient fibroblasts.
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Investigator: Anne Fagan
Project Title: Evaluation of CSF aSynuclein as a novel prognostic biomarker
Date: [208]
Request ID: T1817-A
Aim 1: 1) To elucidate the relationship between CSF aSN levels, clinical/cognitive measures and other AD-related CSF biomarkers.
Aim 2: 2) To evaluate the utility of CSF aSN as a prognostic biomarker that is predictive of time until death.
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Investigator: Gregory S Day
Project Title: RT-QuIC testing in “preclinical” CJD
Date: [208]
Request ID: T1904
Aim 1: To determine the sensitivity of RT-QuIC testing in CSF obtained from research participants who were eventually diagnosed with sporadic CJD.
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Investigator: Randall Bateman
Project Title: ApoE proteoforms in the human CNS and validation of translational ApoE pharmacodynamic markers
Date: [208]
Request ID: T1903
Aim 1: Aim 1: Characterize ApoE truncations, fragments, and post-translational modifications found in human brain, CSF and plasma.
Aim 2: Aim 2: Target ApoE and A� kinetics in an AD animal model expressing human ApoE and human A� treated with an ApoE LDLR upregulation (clearance activator) or ASO ApoE knockdown (production inhibitor) to assess whether targeting ApoE levels changes ApoE and A� kinetics.
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