The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Jee-young Han
Project Title: 2. Characteristics of atypical AD and use of amyloid markers
Date: December 21, 2021 at 5:18 pm
Request ID: D1622
Aim 1: To demonstrate prevalence of amyloid biomarkers in atypical dementia (non-AD dementia(uncertain or mixed) and AD with unusual features)
Aim 2: To determine the utility of amyloid biomarkers in diagnosing atypical AD in atypical dementia
Aim 3: To characterize atypical dementia in MAP cohort
Aim 4: To determine rate of cognitive decline in atypical AD dementia and non-AD dementia
Investigator: Palanca
Project Title: White Matter Markers Linking Delirium and AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1910
Aim 1: Compare DTI measures of cingulum bundle integrity among patients with recent delirium and controls with preclinical or early AD
Aim 2:
Aim 3:
Aim 4:
Investigator: C Karch, GS Day
Project Title: Molecular mechanisms of the central regulator of TREM2 dysfunction (Clinical Correlation Substudy)
Date: December 21, 2021 at 5:18 pm
Request ID: D1909
Aim 1: Define the effects of common MS4A4A variants on the clinical expression of AD and related dementias, and disease-associated biomarkers profiles.
Aim 2:
Aim 3:
Aim 4:
Investigator: Gregory S Day
Project Title: Investigating Reliability in Reporting of Medical History in Knight ADRC Participants
Date: December 21, 2021 at 5:18 pm
Request ID: D1908
Aim 1: Determine the reliability of reported past medical history of stroke and diabetes in Knight ADRC participants.
Aim 2: Quantify the in?uence of measured variables on reliability in reporting of past medical history of stroke and diabetes in Knight ADRC participants.
Aim 3:
Aim 4:
Investigator: Colin L Masters
Project Title: NIH Grant CSF Data Harmonisation
Date: December 21, 2021 at 5:18 pm
Request ID: D1907
Aim 1: Assess the biomarker trajectories of participants from AIBL, ADNI and the ACS that have at least three follow up time points
Aim 2:
Aim 3:
Aim 4:
Investigator: Catherine Roe
Project Title: Characteristics and Outcomes of Uncertain Dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1906
Aim 1: What characteristics of the participant distinguish people diagnosed with CDR 05/uncertain dementia from CDR/0 and CDR 0.5/AD individuals?
Aim 2: What characteristics of CDR 0.5/uncertain predict future progression in cognition and to AD?
Aim 3: To what extent does cognitive impairment progress over time among participants with uncertain diagnoses who do not develop AD?
Aim 4:
Investigator: Chihiro Sato
Project Title: Profiling CSF Tau isoforms by Mass Spectrometry for the Diagnosis of Tauopathies
Date: December 21, 2021 at 5:18 pm
Request ID: D1905
Aim 1: to collect CSF and matching plasma from various tauopathies and profile CSF tau to improve early diagnostics
Aim 2:
Aim 3:
Aim 4:
Investigator: Arthur Simen, Adam Schwarz
Project Title: Utility of a digital cognitive endpoint in early POC studies in AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1904
Aim 1: Assess patient compliance on the ARC app
Aim 2: Generate preliminary estimates of relationships between ARC measures and A/T/N biomarker classification
Aim 3: Generate preliminary estimates of how performance on the ARC app relates to performance on traditional paper and pencil cognitive measures, regional distribution of tau and/or CSF P-Tau and cortical atrophy measured at the same point in time
Aim 4:
Investigator: Dr Noel Faux
Project Title: Replicating and evaluating blood-based AD risk signatures
Date: December 21, 2021 at 5:18 pm
Request ID: D1903
Aim 1: To replicate our blood-based predictive models of CSF AB 1-42 and tau
Aim 2: To evaluate the prognostic and clinical utility of our blood-based predictive models
Aim 3: Determine the utility of genomic risk scores when predicting CSF biomarkers
Aim 4: Evaluate the ability to predict other CSF based biomarkers
Investigator: Cho-Yi Chen
Project Title: Reproduce the Results from Musiek et al. (2018): Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1901
Aim 1: Reproduce the results from Dr. Yo-El Lu’s paper in JAMA Neurology (Musiek et al., 2018) and apply the same methodology to our dataset.
Aim 2:
Aim 3:
Aim 4: