The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Profofessor Vanessa Raymont, Dr Ivan Koychev
Project Title: Longitudinal Biomarker Trajectories and Event-Based Outcomes in Predicting Dementia Risk: A Joint Modelling Approach
Date: February 16, 2025 at 11:12 am
Request ID: D2601 Yang
Aim 1: Explore the ability of longitudinal blood-based biomarkers (e.g., pTau217, % pTau217, pTau181, Aβ42/40 ratio) to detect heterogeneity in dementia-related disease trajectories, and evaluate the predictive accuracy for diagnostic progression and PET/CSF biomarker conversion, and clinical relevance…
Aim 2: Evaluate whether multi-marker blood-based biomarker profiles (e.g., plasma pTau217, pTau181, NfL, GFAP, and Aβ42/40) can identify biologically distinct disease subgroups at a given time point and characterize how individuals transition between these biomarker-defined states over time…
Aim 3: Determine whether renal function, indexed by estimated glomerular filtration rate (eGFR), modifies longitudinal blood-based biomarker trajectories and their predictive performance for diagnostic progression and PET/CSF biomarker conversion in Alzheimer’s disease.
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Investigator: Joel Perlmutter
Project Title: Resting State Functional Connectivity in Alzheimer and Parkinson Diseases
Date: February 14, 2025 at 6:46 pm
Request ID: D2513
Aim 1: Examine resting state fMRI functional connectivity matrices and spectral biomarkers in participants with AD and PD and their respective control groups
Aim 2: Analyze the extent to which FC changes characteristic of AD and PD resemble features known to index level of arousal
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Investigator: Devin Drown
Project Title: A combined re-analysis of Alzheimer’s Disease and the Human Gut Microbiome
Date: February 6, 2025 at 5:37 pm
Request ID: D2512
Aim 1: I am an undergraduate researcher at the University of Alaska Fairbanks, working on an independent project to re-analyze multiple data sets. My goal is to take the raw sequence reads and process them all through the same databases to examine trends
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Investigator: Paul Aisen (USC, primary award), B. Joy Snider (Wash U sub award)
Project Title: Alzheimer Clinical Trial Consortium Brain Donation Progra
Date: February 6, 2025 at 2:58 pm
Request ID: D2511
Aim 1: To offer brain donation to clinical trial participants. Autopsy on these participants has the potential to provide meaningful data to confirm the impact of interventions on neuronal integrity, disease processes, as well as the impact brain and disease etiology may have on efficacy of different inte
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Investigator: Zhongwei Zhang
Project Title: Multi-shell Diffusion Modeling
Date: January 31, 2025 at 11:24 pm
Request ID: D2510
Aim 1: Investigating the Impact of Pre-Processing on Multi-Shell Diffusion Models
Aim 2: Multi-Shell Hybrid Models Development
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Investigator: Oskar Hansson
Project Title: Biological staging of AD using plasma %p-tau217 and eMTBR-tau243
Date: January 27, 2025 at 8:26 pm
Request ID: D2509
Aim 1: Derive a biological staging model of AD using plasma %p-tau217 and eMTBR-tau243
Aim 2: Compare the biological staging model to other AD-relevant measures
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Investigator: Haotian Zou
Project Title: Developing an Integrative Predictive Model for Alzheimer’s Disease Progression Using Multi-Modal Data from Knight-ADRC and Other Cohorts
Date: January 22, 2025 at 2:00 pm
Request ID: D2508
Aim 1: To develop a robust predictive model for AD progression by integrating multi-modal data, including longitudinal clinical data, MRI data, and omics data.
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Investigator: Abdallah Eteleeb
Project Title: Unraveling the impact of disease comorbidities in Alzheimer’s disease through multi-omics integration
Date: January 22, 2025 at 9:58 am
Request ID: D2507
Aim 1: Identify comorbidities associated with specific molecular profiles of Alzheimer’s disease through multi-omics data integration
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Investigator: Dr. Chengjie Xiong
Project Title: Investigate racial differences in the CDR item level data.
Date: January 13, 2025 at 5:04 pm
Request ID: D2506
Aim 1: Assess CDR item level data for possible racial differences along with AD biomarkers
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Investigator: Jennifer Yokoyama
Project Title: Comparative Analysis of Genetic Variants Associated with Interferon Response in Alzheimer’s Disease Using the OASIS Dataset
Date: January 13, 2025 at 2:57 pm
Request ID: D2505
Aim 1: Explore immunogenetic mechanisms of Alzheimer’s disease using clinical progression data and neuroimaging
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