The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Fujirebio Diagnostics Inc
Project Title: Fujirebio ADRC Sample Request
Date: [208]
Request ID: T1721
Aim 1: to establish a Lumipulse G β-Amyloid 1-42 assay cutoff for distinguishing AD vs. HC in an autopsy confirmed LOAD population with appropriate clinical data.
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Investigator: Sally Temple/Celeste Karch
Project Title: iPSC Modeling of AD Using Progerin
Date: [208]
Request ID: T1720
Aim 1: Is prelamin A expression and processing perturbed in AD brains?
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Investigator: David Holtzman
Project Title: Validation of novel human apoE antibody staining in human AD tissue
Date: [208]
Request ID: T1719
Aim 1: Determine whether novel human apoE antibody detects apoE in plaques from AD patients
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Investigator: Jerold Chun
Project Title: Neural Genomic Mosaicism (NGM) in Neurodegenerative disorders
Date: [208]
Request ID: T1718
Aim 1: Identify NGM changes defined by DNA content variation (DCV) that track with neurodegenerative diseases
Aim 2: Conduct small population and single-cell genomic and transcriptomic analyses on positive samples from Aim 1 to identify altered genes and pathways
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Investigator: John Kauwe
Project Title: Cell free single stranded DNA concentration in CSF as biomarker to diagnose Alzheimer�s disease status
Date: [208]
Request ID: T1717
Aim 1: Determine the association between cell free single stranded DNA concentration in CSF and Alzheimer�s disease status
Aim 2: Establish if cell free single stranded DNA in CSF can be use as biomarker to diagnose Alzheimer�s disease.
Aim 3: Observe any variability between non-demented CSF serum and Alzheimer�s case CSF serum such as number of cell count, and nucleonic material.
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Investigator: Eric A. Schon
Project Title: Diagnosis of AD based on perturbed MAM function in blood and CSF
Date: [208]
Request ID: T1716
Aim 1: To test the hypothesis that AD can be diagnosed in blood (e.g. whole blood, fractionated blood components, plasma, and serum) and/or CSF based on the analysis of phenotypes associated with increased ER-mitochondrial communication
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Investigator: Beth Stevens
Project Title: of Microglia and Complement in Synapse Loss in Alzheimer�s Disease
Date: [208]
Request ID: T1715
Aim 1: Examine synapse-associated complement proteins in human AD tissue
Aim 2: Examine synaptic proteins inside microglia in human AD tissue
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Investigator: Timothy Miller
Project Title: Analysis of longitudinal c9orf72 G4C2 repeat expansion in non-expanded individuals
Date: [208]
Request ID: T1714
Aim 1: Analyze G4C2 expansion in longitudinal samples (>10 years apart)
Aim 2: Analyze G4C2 expansion in multigenerational samples
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Investigator: Gregory Storch
Project Title: Defining the Human Neurovirome Using Next-Generation Sequencing
Date: [208]
Request ID: T1713
Aim 1: To use next-generation sequencing with ViroCap to evaluate the neurovirome in individuals with known viral infections of the brain, individuals with neurologic disease not thought to have an infectious etiology, and individuals without neurologic disease
Aim 2: To use next-generation sequencing with ViroCap to search for viruses in brain samples from individuals with neurologic disease of unknown etiology, including Alzheimer’s disease
Aim 3: To investigate the impact of immunosuppressin on the neurovirome
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Investigator: Jan Bieschke
Project Title: Superresultion imaging of amyloid structures by transient amyloid binding (TAB)
Date: [208]
Request ID: T1712
Aim 1: To test the hypothesis that TAB imaging can differentiate non-fibrillar aggregates and amyloid fibrils (a) in vitro, (b) ex vivo, and (c) in prion-like strains.
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