The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Rosa Rademakers
Project Title: Whole-genome sequencing in FTLD-TDP patients – amendment to T1618
Date: [208]
Request ID: T1618-A
Aim 1: Discovery of novel genetic elements associated with FTLD-TDP
Aim 2: Replication and characterization of novel genetic elements associated with FTLD-TDP
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Investigator: Timothy Miller
Project Title: Pathologic characterization of selective autophagy in ALS/FTD andAlzheimer’s Disease
Date: [208]
Request ID: T1807
Aim 1: Biochemical and molecular analysis of selective autophagy genes in ALS, FTD and AD spinal cord and brain
Aim 2: Biochemical and molecular characterization of autophagosome and lysosomal markers in ALS, FTD, and AD spinal cord and brain
Aim 3: Correlate expression levels of selective autophagy genes and autophagosome/lysosome markers to clinical characteristics in ALS, FTD, and AD
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Investigator: Holtzman, David
Project Title: Single-nuclei transcriptomic profiling of microglia in AD-associated TREM2 variant carriers
Date: [208]
Request ID: T1806 Ulrich
Aim 1: Assess microglial transcriptome in TREM2-cv and TREM2-R47H AD cases
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Investigator: Laura Piccio. Carlos Cruchaga
Project Title: TREM2 as a key player and a potential biomarker in Alzheimer’s disease.
Date: [208]
Request ID: Pilot 31.4_C (3rd Amendement to ADRC Pilot)
Aim 1: To determine whether the CSF and serum levels of sTREM2 are associated with clinical AD and/or with a TREM2-variant carrier status
Aim 2: To identify genetic modifiers of TREM2
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Investigator: Frank M. LaFerla
Project Title: Tau underlies synaptic and cognitive deficits for type 1, but not for type 2 diabetes
Date: [208]
Request ID: T1805
Aim 1: Is Tau necessary for T2DM-mediated cognitive impairments?
Aim 2: Determine molecular pathways by which diabetes impairs synaptic and cognitive function
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Investigator: Thomas Wingo
Project Title: A PROTEOGENOMIC APPROACH TO UNDERSTANDING AD GWAS RESULTS
Date: [208]
Request ID: T1804
Aim 1: To resequence genes in LD with all AD-associated GWAS markers.
Aim 2: To define absolute levels and stability for proteins encoded by genes in LD with AD-associated GWAS markers
Aim 3: Correlate genomic sequence variants with brain-derived absolute protein levels.
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Investigator: Tien-Phat Huynh
Project Title: Characterizing a novel variant of the apolipoprotein and its role in Alzheimer disease pathogenesis
Date: [208]
Request ID: T1803
Aim 1: To examine the effects of the L28P variant on apoE and A� levels in the brain and the CSF of AD patients
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Investigator: Chihiro Sato
Project Title: Quantitative analysis of tau phosphorylation and isoforms in Brain, CSF, and cell culture models
Date: [208]
Request ID: T1722-B
Aim 1: We hypothesize the existence of an interplay between �-amyloidosis and tau hyper phosphorylation at T217 prior to tau aggregation
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Investigator: Iliya Lefterov; Radosveta Koldamova
Project Title: Age dependent APOE isoform specific effect on immune receptor mediated phagocytosis in brain
Date: [208]
Request ID: T1802
Aim 1: Determine age related APOE isoform-specific effect on transcriptomic and molecular phospholipid profiling in brain
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Investigator: Tien-Phat Huynh
Project Title: The isoform-dependent effects of APOE in the aggregation cascade of A� peptide
Date: [208]
Request ID: T1801
Aim 1: Study the effects of different apoE isoforms on the potency of A� seeds derived from human AD brains
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