The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Joseph M Castellano
Project Title: Plasma protein-mediated effects of ApoE4 expression on brain in AD
Date: [208]
Request ID: T1902
Aim 1: To investigate plasma protein differences between cognitively normal human subjects homozygous for APOE-e4 or APOE-e3 alleles using aptamer-based protein platform for ~1000 proteins to identify pathways and regulators of peripheral dysfunction impacting brain health.
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Investigator: Courtney Sutphen
Project Title: Simoa Plasma Assay for Neurofilament Light Chain (NfL)
Date: [208]
Request ID: T1901
Aim 1: Evaluate analytical performance of the Quanterix Simoa plasma assay for NfL
Aim 2: Evaluate correspondence of plasma NfL with established CSF and imaging biomarkers of AD
Aim 3: Evaluate diagnostic performance of plasma NfL
Aim 4: Characterize the profile of longitudinal plasma NfL
Investigator: David Holtzman
Project Title: Assessment of neuritic plaque p-tau, A�42, and microgliosis in AD-associated TREM2 variant carriers
Date: [208]
Request ID: T1419-A
Aim 1: Assess plaques assoicated tau and p-tau staining and Ab42 staining TREM2 WT and R47H/R62H carriers
Aim 2: Biochemically assess soluble and insoluble tau and p-tau levels
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Investigator: Randall Bateman M.D.
Project Title: A blood isotope labeled amyloid-beta test for Alzheimer’s disease
Date: [208]
Request ID: T1822
Aim 1: To determine blood Aβ isoform level relationships to CSF Aβ and amyloid PET, using archived blood samples from cross-sectional and longitudinal studies of cognitively normal, AD, and other neurodegenerative dementias.
Aim 2: We would like to explore if there are changes (perhaps diffuse plaques or biochemical changes) in the neuropathology cases that also have collected blood samples near the time of brain donation (within 1 or 2 years is best)
Aim 3: The hypothesis is that the plasma abeta42/40 will be abnormal at times when amyloid plaque (including diffuse) begins and before PET scans would detect it.
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Investigator: Wim Annaert
Project Title: Lysosomal functions of PLD3 in health and Alzheimer’s disease
Date: [208]
Request ID: T1821
Aim 1: Identify PLD3 (dys-)functions in endo-lysosomal homeostasis and how this connects to LOAD
Aim 2: Omics analysis of lysosomes isolated from wild-type and PLD3 variant carriers
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Investigator: Norelle C. Wildburger
Project Title: In vivo metabolic imaging of Aβ deposition and toxicity
Date: [208]
Request ID: T1708-A
Aim 1: Quantify in vivo Aβ proteoform deposition from human Alzheimer?s disease using stable isotope label kinetics
Aim 2: Build a computational mathematical framework that accurately quantifies 13C6-leucine-labeled Abeta deposition into the insoluble abeta fraction in human AD brain
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Investigator: Marc Diamond
Project Title: Analysis of tau strain types familial Alzheimer’s Disease
Date: [208]
Request ID: T1819
Aim 1: Analysis of tau strain types in cases of familial Alzheimer’s Disease (FAD) using a panel of cellular biosensors
Aim 2: Comparison of the seeding data from tau strain(s) identified in FAD data to cases of sporadic Alzheimer’s Disease
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Investigator: Joel S Perlmutter
Project Title: Imaging VAChT in Parkinson disease
Date: [208]
Request ID: T1820
Aim 1: identify postmortem correlation between PET findings and autopsy findings of VAChT in brain
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Investigator: Zhude Tu
Project Title: PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTER
Date: [208]
Request ID: T1818 Liu
Aim 1: Determine the feasibility of quantitative VAChT imaging in patients with PSP-RS
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Investigator: John Morris
Project Title: Evaluation of CSF aSynuclein as a biomarker of autopsy-confirmed Lewy Body pathology in a mixed cohort
Date: [208]
Request ID: T1817
Aim 1: Evaluate CSF aSN levels as a biomarker of Lewy body pathology
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