The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Allen D. Roses, MD
Project Title: TOMM40-‘523 haplotype relationship to age of onset of dementia
Date: [208]
Request ID: T1612
Aim 1: Compare the TOMM40-‘523 genotype calls previously obtained with Sanger Sequencing Assay Results
Aim 2: Analyze the interaction between APOE and TOMM40 genotypes and ae of onset of symptomatic Alzheimer’s Disease
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Investigator: G. William Rebeck
Project Title: APOE ISOFORM-SPECIFIC GLYCOSYLATION IN ALZHEIMER�S DISEASE
Date: [208]
Request ID: T1611
Aim 1: identify glycosylated forms of APOE in human plasma
Aim 2: determine whether plasma glyco-APOE species differ by APOE genotype
Aim 3: determine whether plasma glyco-APOE species are altered in Alzheimer’s disease
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Investigator: Carlos Cruchaga and Jin-Moo Lerr
Project Title: Contribution of vascular disease to Alzheimer dementia
Date: [208]
Request ID: T1610
Aim 1: Aim 1: Develop precise imaging biomarker of vascular burden by identifying distinct white matter hyperintensity patterns that are highly correlated with cerebrovascular disease and/or vascular risk factors in a mixed cohort of AD, healthy aging and stroke patients.
Aim 2: Aim2: Validate the novel biomarker for stroke and vascular dementia.
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Investigator: Chihiro Sato
Project Title: Tau Kinetics in the Human CNS
Date: [208]
Request ID: T1609 Sato_Bateman
Aim 1: To assess tau labeling in the human brain 8 days post-mortem
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Investigator: Sidney Strickland
Project Title: Investigation of a prothrombotic state in AD patient plasma
Date: [208]
Request ID: T1306-A
Aim 1: Determine if AD patient plasma exhibits altered clot formation compared to control plasma
Aim 2: Determine if AD patient plasma exhibits altered thrombin generation
Aim 3: Determine correlation between dementia level and APTT profile.
Aim 4: Determine if coagulation factor deficiency affects APTT profile in AD and which factor/pathway is responsible.
Investigator: Feng Lin
Project Title: New biomarkers for Alzheimer’s Disease
Date: [208]
Request ID: T1608
Aim 1: We will analyze CSF samples from control and Alzheimer’s Disease patients to identify potential new biomarkers for future better dignosis of Alzheimer’s Disease
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Investigator: Kelly R. Bales
Project Title: Cerebrospinal Fluid Request
Date: [208]
Request ID: T1607
Aim 1: cross sectional analysis of CSF Ab42:37 ratio across AD continuum (see below for cohort details)
Aim 2: longitudinal analysis of CSF Ab42:37 ratio in subjects that convert to AD (see below for cohort details)
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Investigator: Anne Fagan
Project Title: Roche Elecsys automated CSF assay for Ab42, tau and ptau181
Date: [208]
Request ID: T1606
Aim 1: Evaluate the analytical performance of the automated Roche Elecsys assay for CSF Ab42, tau and ptau181
Aim 2: Evaluate the clinical performance of the automated Roche Elecsys assay for CSF Ab42, tau and ptau181
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Investigator: Anne Fagan
Project Title: Lumipulse Automated CSF Assay for Ab42 and tau
Date: [208]
Request ID: T1605
Aim 1: To test Lumipulse CSF Ab42 and tau methodologic assay performance
Aim 2: To compare CSF biomarker profiles between African Americans and European Americans
Aim 3: To evaluate the correspondence between Lumipulse Ab42 and cortical amylioid load defined by PIB PET
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Investigator: Tammie L.S. Benzinger
Project Title: quantification of neuroinflammation and neurodegeneration in AD using DBSI
Date: [208]
Request ID: T1604
Aim 1: Validate DBSI as a biomarker of neuroinflammation in AD
Aim 2: Validate DBSI as neurodegeneration markers in AD
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