The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Beau Ances
Project Title: Gut Dysbiosis and Intestional Dysfunction in AD
Date: [208]
Request ID: T2006
Aim 1: Characterize gut bacterial content and organ permeability in adults in different stages of AD
Aim 2: Identify changes in bacterial content and organ permeability in individuals who advance to preclinical AD or clinical AD.
Aim 3: Compare bacterial content and organ permeability to AD biomarkers obtained from other projects.
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Investigator: Rawan Tarawneh, MD
Project Title: CSF and Plasma Eotaxins As Diagnostic Biomarkers of Alzheimer Disease
Date: [208]
Request ID: T2005
Aim 1: Examine the diagnostic value of CSF and plasma eotaxin-1 and eotaxin-3 in differentiating AD from controls
Aim 2: Investigate correlations of CSF and plasma eotaxins with CSF markers of amyloid and tau pathology (tau, p-tau181, Ab42) and markers of neuronal/synaptic injury (Ng and VILIP-1)
Aim 3: Examine associations of CSF and plasma eotaxins with cross-sectional and longitudinal cognitive assessments (including episodic memory, semantic memory, working memory, visuospatial, and global composite scores) and CDR-SB
Aim 4: Examine correlations of CSF and plasma eotaxins with whole brain and regional atrophy (cross-sectional only)
Investigator: Mary Jo LaDu
Project Title: Oligomeric Ab Levels in Human Plasma as a Mechanistic Biomarker for Alzheimer’s Disease
Date: [208]
Request ID: T2004
Aim 1: Develop a biomarker based on oAb in plasma for early detection of AD and as an endpoint in the therapeutic development of AD treatment.
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Investigator: J�r�me Braudeau, PhD
Project Title: Optimization of a blood diagnosis of the silent phase of Alzheimer’s disease
Date: [208]
Request ID: T2003
Aim 1: Improve our algorithm by learning on new plasma samples from different genetic origin and environmental background
Aim 2: Confirm the performance of the test on North American blood samples
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Investigator: Richard I. Morimoto
Project Title: Drug Discovery to Ameliorate Proteostasis Failure in Tauopathies
Date: [208]
Request ID: T2002
Aim 1: To develop and validate a panel of proteostasis sensors and reporters for all arms of the Proteostasis Network (PN) that robustly and quantitatively reports on each branch of the PN in the context of mutant Tau and the effects of aging.
Aim 2: To test the hypothesis that the age-dependent deficiencies in PN capacity in animal and cell models of Tauopathy can be reset by pharmacologic regulation of the PN employing using small molecule proteostasis regulators (PRs).
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Investigator: Eran Hornstein
Project Title: miRNAs as diagnostic biomarkers for Alzheimer’s disease
Date: [208]
Request ID: T2001
Aim 1: Testing a microRNA classifier for FTD on an AD plasma cohort
Aim 2: Establishing plasma microRNAs as markers for differential diagnosis between AD and FTD
Aim 3: Developing a machine learning algorithm for AD classification based on plasma microRNAs
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Investigator: Mar�a Isabel Behrens
Project Title: Role of senescence on the inverse association between Alzheimer’s Disease and and Cancer
Date: [208]
Request ID: T1011-A
Aim 1: Quantify the number of senescent cells in frontal cortical brain tissue of CDR 0.5 (very early AD) and CDR 2-3 (moderate-advanced AD) patients, with and without a history of any type of cancer in the past
Aim 2: Quantify the number of senescent cells in frontal cortical brain tissue of CDR 0 patients, with and without a history of any type of cancer in the past
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Investigator: Daojing Wang
Project Title: AD-MS Chips for Biofluids-Based Diagnosis of Alzheimer’s Disease
Date: [208]
Request ID: T1423-A
Aim 1: Optimize and validate our platform for early diagnosis of AD
Aim 2: Optimize and validate multiomics assays for early diagnosis of AD
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Investigator: Brian Gordon and Meghan Campbell
Project Title: Comparing novel biomarkers in Alzheimer and Parkinson diseases
Date: [208]
Request ID: T1923
Aim 1: Explore what biomarker profiles differentiate AD and PD cohorts
Aim 2: Relate biomarkers to clinical presentation in both AD and PD cohorts
Aim 3: Compare CSF and plasma NfL measures
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Investigator: Charles Glabe
Project Title: The identification of an antibody or antibodies that serve as AD biomarkers
Date: [208]
Request ID: T1922
Aim 1: Screen plasma or serum for amyloid antibodies using a protein sequence array
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