The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Jaime Grutzendler
Project Title: Cell biology of PLD3 regulation in Alzheimer disease
Date: [208]
Request ID: T2023
Aim 1: Superresolution imaging of PLD3 associated lysosomal partners in AD postmortem brain
Aim 2: Characterization of PLD3 effects on AD neuropathology
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Investigator: Diadem srl
Project Title: U-p53: a new highly specific blood biomarker for Alzheimer�s at pre-clinical and prodromal stages of the disease.
Date: [208]
Request ID: T2022
Aim 1: U-p53 Diagnostic Value of Cognitive stage: U-p53 concentration is higher in CDR≥0.5/AD compared to CDR 0 (Cognitively Normal).
Aim 2: U-p53 Prognostic Value of Cognitive decline: U-p53 concentration in CDR 0 (Cognitive Normal) and who progressed to CDR≥0.5/AD over follow period is higher than CDR 0 (Cognitive Normal) individuals who remained stable over the follow up period.
Aim 3: Evaluation/characterization of the relationship between U-p53 and other AD biomarkers: U-p53 concentrations will correlate with other AD blood and/or CSF biomarkers (e.g., amyloid/tau/p-tau), albeit to different extents
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Investigator: Benzinger / Wang
Project Title: Quantification of Neuroinflammation in Alzheimer’s Disease Using Diffusion Basis Spectrum Imaging
Date: [208]
Request ID: T1604-B
Aim 1: Validate DBSI as a biomarker of neuroinflammation in AD by using quantitative neuropathology using small block post-modem brain tissue
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Investigator: Nicole Coufal
Project Title: Role of BIN1 in Microglia in Tauopathy
Date: [208]
Request ID: T2021
Aim 1: To understand how BIN1 expression in microglia contributes to Alzheimer’s/Tauopathy associated risk
Aim 2: To understand how noncoding GWAS risk alleles in microglia contribute to Alzheimer’s disease risk
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Investigator: Jin-Moo Lee & Abhinav Diwan
Project Title: Recruitment of peripheral monocytes to amyloid plaques
Date: [208]
Request ID: T2020
Aim 1: To determine if peripheral monocytes enter the brains of Alzheimer’s disease patients
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Investigator: Suzanne Schindler
Project Title: Comparison of plasma phosphorylated tau in African Americans and non-Hispanic whites
Date: [208]
Request ID: T2019
Aim 1: To determine whether plasma pTau181 concentrations are lower in African Americans compared to non-Hispanic whites who are matched by age, APOE �4 status, and cognitive status.
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Investigator: Dr. Jonathan Kipnis
Project Title: Anatomical and functional characterization of IL-17Ra expressing neurons
Date: [208]
Request ID: T2018
Aim 1: To investigate the distribution of IL-17Ra expression throughout the healthy mouse brain.
Aim 2: To corroborate the previous results in tissue obtained from healthy human brain tissue.
Aim 3: To probe the electrophysiological properties and microcircuitry of IL-17Ra expressing neurons from mouse.
Aim 4: To characterize the IL-17Ra expression in mouse models of depression as well as human brain tissue obtained from patients diagnosed with depression.
Investigator: Lindsay Farrer
Project Title: Alzheimer Disease Genetic Architecture in African Americans
Date: [208]
Request ID: T2017
Aim 1: Evaluate the relationship between AD and gene expression in brain tissue from AAs and investigate the influence of AA-specific AD risk variants on observed expression differences.
Aim 2: Validate the effect of variants in AKAP9 and 1-2 other promising genes on the production of AD-related pathogenic molecules and neuronal function.
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Investigator: Randall Bateman
Project Title: Protein Biomarkers in the Human CNS in Alzheimers Disease
Date: [208]
Request ID: T2016
Aim 1: Evaluate utility and develop assays for emerging protein biomarkers of Alzheimer’s Disease
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Investigator: Abhinav Diwan / Jin-Moo Lee
Project Title: Detection of peripheral monocytes in AD brains
Date: [208]
Request ID: T2015
Aim 1: To determine if peripheral monocytes can be detected in brains of AD patients
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