Search Existing Data Requests

The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.


Search Terms:


Investigator: Alison Goate/Oscar Harari

Project Title: Identification of genetic factors associated with rate of progression

Date: December 21, 2021 at 5:18 pm

Request ID: D1212

Aim 1: To replicate the association of rs1868402 with rate of progression

Aim 2: To analyze whether other genetic factors associated with CSF ptau181 levels

Aim 3:

Aim 4:


Investigator: Charles DeCarli

Project Title: NACC MRI Genotype Association Studies

Date: December 21, 2021 at 5:18 pm

Request ID: D1211

Aim 1: Acquire MRI data related to TCV and Hippocampal estimates from NACC participating sites

Aim 2: Match MRI data with ADGC acquired genotype data on NACC enrolled subjects

Aim 3: Examine candidate gene associations from prior publications

Aim 4:


Investigator: Allitia DiBernardo

Project Title: ADRC data modeling to support DIAN trial planning

Date: December 21, 2021 at 5:18 pm

Request ID: D1202

Aim 1: Establish longitudinal biomarker profiles in amyloid+ cogntively normal subjects

Aim 2: Establish longitudinal cognitive profiles in amyloid+ cognitively normal subjects

Aim 3: Establish longitudinal biomarker profles in amyloid+ MCI subjects

Aim 4: Evaluate cognitive composites for CN and MCI amyloid+ subjects


Investigator: Dave Balota

Project Title: The Effects of Alzheimer’s Disease and Aging on Cortical Myelination

Date: December 21, 2021 at 5:18 pm

Request ID: D1203

Aim 1: Estimate changes in cortical myelination in healthy aging

Aim 2: Estimate changes in cortical myelination in Alheimer’s disease

Aim 3: Examine the robustness of this technique in two independent samples of healthy older adults

Aim 4:


Investigator: John C Morris

Project Title: Multimodal biomarker prediction

Date: December 21, 2021 at 5:18 pm

Request ID: D1109

Aim 1: Evaluate biomarker combinations that predict clinical outcomes in cognitively normal and DAT persons

Aim 2:

Aim 3:

Aim 4:


Investigator: Chengjie Xiong

Project Title: Two Preclinical Latent Scores to Predict Occurrence of DAT

Date: December 21, 2021 at 5:18 pm

Request ID: D1206

Aim 1: Assess the antecedent longitudinal changes and their predictive power of DAT for individual items of

Aim 2: Aim 2. Evaluate the use of IRT

Aim 3: Develop clinically meaningful score reports

Aim 4:


Investigator: Catherine M. Roe

Project Title: Alzheimer’s disease biomarkers and cancer

Date: December 21, 2021 at 5:18 pm

Request ID: D1207

Aim 1: To examine whether Alzheimer’s disease biomarkers are associated with cancer

Aim 2:

Aim 3:

Aim 4:


Investigator: Zheyu Wang

Project Title: Biomarker Evaluation in the Absence of a Gold Standard

Date: December 21, 2021 at 5:18 pm

Request ID: D1208

Aim 1: Methodology development on evaluating biomarkers in the absence of a gold standard

Aim 2:

Aim 3:

Aim 4:


Investigator: Phillip Hsu

Project Title: Risk factors associated with Headache due to Lumbar Puncture

Date: December 21, 2021 at 5:18 pm

Request ID: D1209

Aim 1: To identify risk factors that increase the likelihood of a post-Lumbar Puncture headache

Aim 2:

Aim 3:

Aim 4:


Investigator: Brooke Sadler

Project Title: The Evolutionary Role of Nicotinic Receptors in Memory and Cognitive Performance

Date: December 21, 2021 at 5:18 pm

Request ID: D1210

Aim 1: Examine association between genotypes in nicotinic receptors with phenotypes related to cognition

Aim 2: Determine if these genotypes are at different frequencies among AD vs non AD participants

Aim 3: Relate these frequency differences back to historical selective pressures on increased cognition

Aim 4: