The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Alison Goate/Oscar Harari
Project Title: Identification of genetic factors associated with rate of progression
Date: December 21, 2021 at 5:18 pm
Request ID: D1212
Aim 1: To replicate the association of rs1868402 with rate of progression
Aim 2: To analyze whether other genetic factors associated with CSF ptau181 levels
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Investigator: Charles DeCarli
Project Title: NACC MRI Genotype Association Studies
Date: December 21, 2021 at 5:18 pm
Request ID: D1211
Aim 1: Acquire MRI data related to TCV and Hippocampal estimates from NACC participating sites
Aim 2: Match MRI data with ADGC acquired genotype data on NACC enrolled subjects
Aim 3: Examine candidate gene associations from prior publications
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Investigator: Allitia DiBernardo
Project Title: ADRC data modeling to support DIAN trial planning
Date: December 21, 2021 at 5:18 pm
Request ID: D1202
Aim 1: Establish longitudinal biomarker profiles in amyloid+ cogntively normal subjects
Aim 2: Establish longitudinal cognitive profiles in amyloid+ cognitively normal subjects
Aim 3: Establish longitudinal biomarker profles in amyloid+ MCI subjects
Aim 4: Evaluate cognitive composites for CN and MCI amyloid+ subjects
Investigator: Dave Balota
Project Title: The Effects of Alzheimer’s Disease and Aging on Cortical Myelination
Date: December 21, 2021 at 5:18 pm
Request ID: D1203
Aim 1: Estimate changes in cortical myelination in healthy aging
Aim 2: Estimate changes in cortical myelination in Alheimer’s disease
Aim 3: Examine the robustness of this technique in two independent samples of healthy older adults
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Investigator: John C Morris
Project Title: Multimodal biomarker prediction
Date: December 21, 2021 at 5:18 pm
Request ID: D1109
Aim 1: Evaluate biomarker combinations that predict clinical outcomes in cognitively normal and DAT persons
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Investigator: Chengjie Xiong
Project Title: Two Preclinical Latent Scores to Predict Occurrence of DAT
Date: December 21, 2021 at 5:18 pm
Request ID: D1206
Aim 1: Assess the antecedent longitudinal changes and their predictive power of DAT for individual items of
Aim 2: Aim 2. Evaluate the use of IRT
Aim 3: Develop clinically meaningful score reports
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Investigator: Catherine M. Roe
Project Title: Alzheimer’s disease biomarkers and cancer
Date: December 21, 2021 at 5:18 pm
Request ID: D1207
Aim 1: To examine whether Alzheimer’s disease biomarkers are associated with cancer
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Investigator: Zheyu Wang
Project Title: Biomarker Evaluation in the Absence of a Gold Standard
Date: December 21, 2021 at 5:18 pm
Request ID: D1208
Aim 1: Methodology development on evaluating biomarkers in the absence of a gold standard
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Investigator: Phillip Hsu
Project Title: Risk factors associated with Headache due to Lumbar Puncture
Date: December 21, 2021 at 5:18 pm
Request ID: D1209
Aim 1: To identify risk factors that increase the likelihood of a post-Lumbar Puncture headache
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Investigator: Brooke Sadler
Project Title: The Evolutionary Role of Nicotinic Receptors in Memory and Cognitive Performance
Date: December 21, 2021 at 5:18 pm
Request ID: D1210
Aim 1: Examine association between genotypes in nicotinic receptors with phenotypes related to cognition
Aim 2: Determine if these genotypes are at different frequencies among AD vs non AD participants
Aim 3: Relate these frequency differences back to historical selective pressures on increased cognition
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