The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Robyn A Honea
Project Title: The Role of Genetic Variation in Alzheimer’s Disease Neurodegeneration
Date: [153]
Request ID: D1121
Aim 1: Assess the relationship of selected candidate genes with MRI phenotypes and cognitive markers of AD
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Investigator: Jessica Nichols (student in Friedman Program)
Project Title: Effect of Type 2 Diabetes Mellitus on Resting State Functional Connectivity
Date: [153]
Request ID: D1120
Aim 1: look at how T2DM affects resting state functional connectivity and if it is a risk factor for AD
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Investigator: Dr. John C. Morris
Project Title: The rule of sleep, personality, and aging: How these interactions affect cognition
Date: [153]
Request ID: D1119
Aim 1: When comparing CDR 0 to CDR 0.5, 0.5’s would have higher levels of neuroticism & sleep difficulties
Aim 2: Within CDR0, those with high neuroticism & sleep difficulties will have lower cognition performance
Aim 3: Of those who progress to higher CDR, more of the high neuroticism and sleep problems group
Aim 4: High neuroticism group show more awakening and activity on actigraphs
Investigator: Joel Perlmutter
Project Title: Effects of Parkinson’s Disease on BOLD Functional Connectivity
Date: [153]
Request ID: D1118
Aim 1: Study effects of PD on BOLD FC in subcortical areas
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Investigator: B. Joy Snider, Anne Fagan
Project Title: CSF biomarkers and rate of cognitive decline in very mild DAT
Date: [153]
Request ID: D1117
Aim 1: Look for correlation between CSF biomarkers and rate of decline in very mild DAT
Aim 2: look for correlation between ApoE genotype and rate of decline in very mild DAT
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Investigator: Carolyn Baum
Project Title: Contribution to a Metaanalysis on Apraxia
Date: [153]
Request ID: D1116
Aim 1: To respond to a request from Francois Osiurak, PhD, for data that was already published
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Investigator: John C. Morris
Project Title: Correlation of AD biomarkers with CDR 0.5 diagnoses
Date: [153]
Request ID: D1115
Aim 1: Correlate PIB retention with CDR 0.5 diagnoses
Aim 2: Correlate CSF levels of Abeta and tau with CDR 0.5 diagnoses
Aim 3: Correlate nWBV and hippocampal volume with CDR 0.5 diagnoses
Aim 4: Correlate pyschometric performance with CDR 0.5 diagnoses
Investigator: Bruno M. Jedynak
Project Title: Statistical Analysis of the Progression of AD
Date: [153]
Request ID: D1114
Aim 1: Validate the findings from ADNI data using ADRC data
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Investigator: Siekyeong Kim
Project Title: Relationship of Cortical Thickness to Brain Morphology and Body Size
Date: [153]
Request ID: D1113
Aim 1: What is the relationship between cortical thickness and head size?
Aim 2: Are there differences in the above relationship by CDR status?
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Investigator: James Galvin
Project Title: Utility of the AD8 in Mild Cognitive Impairment
Date: [153]
Request ID: D1112
Aim 1: Determine the psychometric properties of the AD8 to discriminate MCI from healthy controls
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