The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Investigator: Sarah Hartz
Project Title: eCDR assessment in absence of collateral source
Date: November 16, 2023
Request ID: D2339
Aim 1: Use existing data to develop and evaluate an electronic CDR assessment that can be administered without a collateral source
Investigator: Karin Meeker
Project Title: Biomarker Clustering in Late Onset Alzheimer Disease
Date: November 15, 2023
Request ID: D1915 addendum
Aim 1: Assess the cross-sectional relationships among AD biomarkers and their ability to predict meaningful clinical outcomes.
Investigator: Susy Stark
Project Title: Falls and Preclinical Alzheimer Disease: Mechanisms of functional performance among cognitively normal (CN) older adults
Date: November 1, 2023
Request ID: S1803 amendment
Aim 1: Determine the relationship between brain age and falls among CN older adults.
Aim 2: Determine the relationship between brain age and complex daily task performance among CN older adults.
Investigator: Alison Goate
Project Title: Uncovering the genetic mechanisms of the Chromosome 17q21.31 Tau haplotype on neurodegeneration risk in FTD and PSP
Date: October 30, 2023
Request ID: D2338
Aim 1: Determine impact of H1/H2 haplotypes on gene expression and regulation in human brain across ancestries. Using single nuclear multi-omics and proteomics in brain tissue, we will assess haplotype and cell-type specific differences in gene regulation individuals of European and African ancestry.
Investigator: Oskar Hansson
Project Title: Combining plasma phospho-tau217 and Aβ42/40 to detect early development of amyloid pathology in early Alzheimer’s disease
Date: October 26, 2023
Request ID: D2336
Aim 1: To establish if a combination of p-tau217 and Aβ42/40 performs better than p-tau217 by itself or Aβ42/40 by itself when (1) identifying CU individuals and patients with MCI who have abnormal brain Aβ burden and (2) predicting change in brain Aβ burden over time.
Investigator: John Morris
Project Title: Sex differences in Alzheimers Disease
Date: October 26, 2023
Request ID: D2337
Aim 1: Are women at an increased risk of developing AD?
Aim 2: Determine sex-specific differences in the clinical manifestations of AD symptomatology as a function of pathology.
Aim 3: Determine if the relationship between AD biology, particularly tau as measured by PET, and cognition varies by sex.
Aim 4: Do men and women show differences in amyloid, tau, and cognition as a function of sex and APOE status? Are there additional factors that might vary by sex?
Investigator: Anne Cross
Project Title: Alzheimer disease pathology in multiple sclerosis
Date: October 24, 2023
Request ID: D2335
Aim 1: Determine if the rate of AD are reduced in patients with multiple sclerosis
Investigator: Andrew Aschenbrenner
Project Title: Clarifying the role of personality in moderating the risk of developing Alzheimer disease
Date: October 19, 2023
Request ID: D2334
Aim 1: Determine the direction of casuality between personality traits and AD pathology
Aim 2: Evaulate lifestyle factors as potential mediators of the personality-pathology relationship
Investigator: Pr Olivier GODEFROY
Project Title: Amyloidopathy and poststroke cognitive impairment: Individual-based meta-analysis
Date: October 13, 2023
Request ID: D2333
Aim 1: to determine the prevalence of amyloid PET positivity in poststroke (PS) patients
Aim 2: to determine the general, cognitive and stroke characteristics of PS patients according to amyloid PET status (cross-sectional)
Aim 3: to determine the general and cognitive outcome of PS patients according to amyloid PET status (follow-up study)
Aim 4: to provide a model of the relationships between cognitive status and imaging characteristics (lesion location, volume, atrophy…)according to amyloid PET status (follow-up study)
Investigator: Jason Ulrich
Project Title: APOE Risk and Novel Inflammatory Fluid Biomarkers for Predicting AD
Date: October 6, 2023
Request ID: D2332
Aim 1: Characterization of the relationships between inflammatory proteins that vary by APOE genotype in preclinical AD.
Aim 2: Characterization of the relationships between inflammatory proteins that vary by APOE genotype in symptomatic AD.
Aim 3: Assess predictive performance of CSF inflammatory markers for CDR conversion in amyloid-positive individuals.