The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: C Karch, GS Day
Project Title: Molecular mechanisms of the central regulator of TREM2 dysfunction (Clinical Correlation Substudy)
Date: December 21, 2021 at 5:18 pm
Request ID: D1909
Aim 1: Define the effects of common MS4A4A variants on the clinical expression of AD and related dementias, and disease-associated biomarkers profiles.
Aim 2:
Aim 3:
Aim 4:
Investigator: Palanca
Project Title: White Matter Markers Linking Delirium and AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1910
Aim 1: Compare DTI measures of cingulum bundle integrity among patients with recent delirium and controls with preclinical or early AD
Aim 2:
Aim 3:
Aim 4:
Investigator: Nico Dosenbach
Project Title: Associating neuroimaging markers of AD with healthy brain organization
Date: December 21, 2021 at 5:18 pm
Request ID: D1911
Aim 1: To determine whether PET images of Beta-Amyloid and Tau have a spatial brain distribution similar to the distribution of Default network substructures observed in healthy individuals
Aim 2:
Aim 3:
Aim 4:
Investigator: Colin L Masters
Project Title: NIH Grant CSF Data Harmonisation
Date: December 21, 2021 at 5:18 pm
Request ID: D1907
Aim 1: Assess the biomarker trajectories of participants from AIBL, ADNI and the ACS that have at least three follow up time points
Aim 2:
Aim 3:
Aim 4:
Investigator: Catherine Roe
Project Title: Characteristics and Outcomes of Uncertain Dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1906
Aim 1: What characteristics of the participant distinguish people diagnosed with CDR 05/uncertain dementia from CDR/0 and CDR 0.5/AD individuals?
Aim 2: What characteristics of CDR 0.5/uncertain predict future progression in cognition and to AD?
Aim 3: To what extent does cognitive impairment progress over time among participants with uncertain diagnoses who do not develop AD?
Aim 4:
Investigator: Chihiro Sato
Project Title: Profiling CSF Tau isoforms by Mass Spectrometry for the Diagnosis of Tauopathies
Date: December 21, 2021 at 5:18 pm
Request ID: D1905
Aim 1: to collect CSF and matching plasma from various tauopathies and profile CSF tau to improve early diagnostics
Aim 2:
Aim 3:
Aim 4:
Investigator: Arthur Simen, Adam Schwarz
Project Title: Utility of a digital cognitive endpoint in early POC studies in AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1904
Aim 1: Assess patient compliance on the ARC app
Aim 2: Generate preliminary estimates of relationships between ARC measures and A/T/N biomarker classification
Aim 3: Generate preliminary estimates of how performance on the ARC app relates to performance on traditional paper and pencil cognitive measures, regional distribution of tau and/or CSF P-Tau and cortical atrophy measured at the same point in time
Aim 4:
Investigator: Yong Wang
Project Title: Tensor Analysis of BOLD Signals in Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1902
Aim 1: Characterize the white matter BOLD tensor in normal aging and AD
Aim 2: Evaluate the relationsihp between white matter BOLD tensor and cognitive status in AD
Aim 3: Characterize the gray matter BOLD tensor in normal aging and AD
Aim 4: Evalaute the regional BOLD tensor connectivity in normal aging and AD
Investigator: Cho-Yi Chen
Project Title: Reproduce the Results from Musiek et al. (2018): Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1901
Aim 1: Reproduce the results from Dr. Yo-El Lu’s paper in JAMA Neurology (Musiek et al., 2018) and apply the same methodology to our dataset.
Aim 2:
Aim 3:
Aim 4:
Investigator: Mark McAvoy
Project Title: Exploring mean global and local BOLD signals in healthy aging and dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1729
Aim 1: Compare the mean global signal with current biomarkers of disease pathology
Aim 2:
Aim 3:
Aim 4: