The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: GS Day
Project Title: Identifying Factors that Influence Participation in MAP CSF Biomarker Studies
Date: December 21, 2021 at 5:18 pm
Request ID: D1811
Aim 1: Identify participant-specific factors that influence participation in CSF biomarker studies in MAP participants.
Aim 2: Identify procedural factors that influence participation in CSF biomarker studies in MAP participants.
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Investigator: None
Project Title: Impact of Race in Reported Memory Problem
Date: December 21, 2021 at 5:18 pm
Request ID: D1810
Aim 1: The primary aim is to determine whether the self-reported versus informant-reported memory problems in African American and Non-Hispanic White non-demented and very mildly of mildly demented Alzheimer disease (AD) individuals correlate with cognitive performance and progression of cognitive dysfunct
Aim 2: Secondary aim includes determining if there is any correlation or racial difference in self-reported and informant reported memory problems and psychometric testing.
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Investigator: Anne Fagan
Project Title: Evaluation of alpha-synuclein in CSF of MAP participants who have come to autopsy
Date: December 21, 2021 at 5:18 pm
Request ID: D1809
Aim 1: evaluate the potential utility of measures of CSF aSN as a marker of underlying LB pathology in LOAD
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Investigator: Lindsay Farrer; Gyungah Jun
Project Title: Genomic and Biological Studies of APOE e2 in Alzheimer�s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1808
Aim 1: Conduct an AD GWAS among APOE ɛ2 carriers using HRC-imputed ADGC datasets to confirm preliminary association findings and identify new loci, and replicate top findings in independent samples.
Aim 2: Validate and identify new functional variants for AD-associated loci using whole exome and whole genome sequence data.
Aim 3: Perform pathway analyses to elucidate pathways and mechanisms linking genes to disease.
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Investigator: Fuhai Li
Project Title: To uncover neuron-inflammation and immune signaling pathways in AD microenvironment using computational models and single cell omics data
Date: December 21, 2021 at 5:17 pm
Request ID: D2111
Aim 1: Aim 1: To develop novel computational models to uncover the activated core signaling networks within individual cell types; and identify the neuron-niche cell signaling interaction networks; and their associations with neuro-inflammation and immune signaling using single cell RNA-seq and proteomics
Aim 2: Aim 2: To develop novel computational models to predict drugs and drug combinations that can perturb the neuro-niche cell signaling communications to inhibit neuro-inflammation and immune response.
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Investigator: John C. Morris
Project Title: Brain Aging associated with Sleep and Heart Health (BASH)
Date: December 21, 2021 at 5:17 pm
Request ID: D2110
Aim 1: Determine whether cardiovascular health risk factors mediate effects of sleep on cognition
Aim 2: Determine whether cardiovascular health risk factors mediate effects of sleep on brain structure
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Investigator: Shea Andrews
Project Title: Association of mitochondrial DNA copy number with AD neuropathological change
Date: December 21, 2021 at 5:17 pm
Request ID: D2018
Aim 1: Evaluate association of mitochondrial DNA copy number with neuropathological diagnosis of AD
Aim 2: Evaluate association of mitochondrial DNA copy number with AD neuropathology
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Investigator: Jason Hassenstab
Project Title: Does sundowning occur in preclinical and early stage Alzheimer disease?
Date: December 21, 2021 at 5:17 pm
Request ID: D2017
Aim 1: Assessing whether increasing AD pathology is associated with mild sundowning behaviors, manifesting in short term decline in cognition even in the asymptomatic preclinical and early symptomatic stages of Alzheimer disease.
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Investigator: Nure Alom Nobel
Project Title: Alzheimer’s Disease Detection Using Deep Learning.
Date: December 21, 2021 at 5:17 pm
Request ID: D2016
Aim 1: How Alzheimer’s Disease affects the human brain and what changes are made in the brain.
Aim 2: We can know whether a patient has AD or not.
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Investigator: Jorge J Llibre-Guerra
Project Title: Proposal for comparison between Dominantly Inherited Alzheimer Disease and sporadic early-onset Alzheimer’s disease.
Date: December 21, 2021 at 5:17 pm
Request ID: D2015
Aim 1: To compare clinical presentation, neuropsychological performance and cognitive decline rate between DIAD and sporadic EOAD.
Aim 2: To examine in vivo the regional distribution of tau, amyloid-β, brain glucose metabolism, and structural atrophy, as well as their relationships, in DIAD and sporadic EOAD.
Aim 3: To compare CSF biomarkers levels and rate of change in DIAD and sporadic EOAD.
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