The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Tharick Pascoal
Project Title: Comparison of CT-based and MR-based processing for tau PET regional quantification
Date: November 13, 2025 at 4:29 pm
Request ID: D2549
Aim 1: We aim to develop and validate a PET-CT–based quantification pipeline that repurposes the CT acquired with PET as anatomical reference, eliminating the need for PET-to-MR registration while maintaining quantitative accuracy.
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Investigator: MARCO AIELLO
Project Title: Multimodal relationship between microstructural and functional markers of dementia
Date: November 13, 2025 at 3:28 am
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Aim 1: To investigate the role of microstructural patterns as early marker of neurodegeneration
Aim 2: To investigate the mutual relationship between microstructure and PET imaging markers
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Investigator: Dimitri Mantovani
Project Title: Multi-Cohort Tau-PET Evaluation Across the Alzheimer’s Continuum: APOE Genotype-Stratified Analysis
Date: November 3, 2025 at 2:35 pm
Request ID: D2548
Aim 1: Evaluate if APOE ε4 homozygotes exhibit an earlier and faster accumulation of tau pathology compared to ε3 homozygotes, even after accounting for amyloid burden
Aim 2: Evaluate the spatial distribution of tau accumulation differs by APOE genotype, with ε4 carriers showing earlier involvement of limbic and association cortices
Aim 3: Evaluate if APOE ε4–related acceleration of tau deposition mediates earlier cognitive decline, bridging the gap between sporadic AD and genetically determined forms such as autosomal dominant AD and Down syndrome
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Investigator: Bin Zhang
Project Title: Integrative Regulatory Network Analysis of Multi-Omics Data Across Brain, Plasma, and CSF in Alzheimer’s disease
Date: November 3, 2025 at 10:33 am
Request ID: D2547
Aim 1: Construct and characterize tissue-specific coexpression networks across brain, CSF, and plasma
Aim 2: Integrate multi-omics networks to identify shared and tissue-specific molecular signatures and key drivers of AD
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Investigator: Zhe Zhao
Project Title: Data-Driven Molecular Subtyping of Alzheimer’s Disease Using Multi-Modal Biomarkers
Date: October 31, 2025 at 7:42 am
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Aim 1: Integrate demographic, clinical, biomarker, genetic, imaging, and CSF proteomic data to create a comprehensive dataset representing key molecular and clinical dimensions of Alzheimer’s disease.
Aim 2: Apply dimensionality reduction and unsupervised clustering to identify reproducible AD molecular subtypes reflecting synaptic, inflammatory, metabolic, and myelin-related heterogeneity.
Aim 3: Develop and validate a ridge-regression classifier to assign subtype probabilities to individuals and evaluate its reproducibility and generalizability across multiple independent cohorts.
Aim 4: Use longitudinal clinical and biomarker data to determine subtype-specific risks for cognitive decline and MCI-to-AD conversion through Cox and mixed-effects modeling.
Investigator: Rohan Palmer
Project Title: Proteomic Associations with AD in CSF
Date: October 29, 2025 at 5:26 pm
Request ID: D2546
Aim 1: Sample size calculation of therapeutic intervention for modifying NPTX2:YWHAG1 ratios
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Investigator: Francesca Farina
Project Title: Advancing Female-Specific Predictive Models and Risk Assessment Tools for Alzheimer’s Disease in the US and Latin America
Date: October 27, 2025 at 1:21 pm
Request ID: D2545
Aim 1: Our project aims to develop predictive models of Alzheimer’s disease risk that are specific to women, focusing on reproductive history and hormonal transitions, and how these factors interact with lifestyle, vascular, genetic, and social determinants.
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Investigator: Tom Hardwicke
Project Title: Data access and reproducibility check
Date: October 16, 2025 at 6:11 pm
Request ID: D2544
Aim 1: Data access and reproducibility check
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Investigator: Mingxia Liu
Project Title: Multimodal Neuroimage Analysis for Accessing Clinical Progression of Subjective Cognitive Decline
Date: October 14, 2025 at 5:44 pm
Request ID: D2543
Aim 1: Explore how deep learning and generative models can be leveraged to synthesize PET to enhance the predictive power of early AD biomarkers.
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Investigator: Xue Wang
Project Title: Studying neurodegenerative diseases using iPSC-derived models
Date: October 1, 2025 at 10:33 am
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Aim 1: Identify appropriate iPSC lines with robust phenotypic differences
Aim 2: Evaluate novel therapeutic strategies using iPSC models
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