Search Existing Data Requests

The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.


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Investigator: Jorge J Llibre-Guerra

Project Title: Proposal for comparison between Dominantly Inherited Alzheimer Disease and sporadic early-onset Alzheimer’s disease.

Date: [153]

Request ID: D2015

Aim 1: To compare clinical presentation, neuropsychological performance and cognitive decline rate between DIAD and sporadic EOAD.

Aim 2: To examine in vivo the regional distribution of tau, amyloid-β, brain glucose metabolism, and structural atrophy, as well as their relationships, in DIAD and sporadic EOAD.

Aim 3: To compare CSF biomarkers levels and rate of change in DIAD and sporadic EOAD.

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Investigator: Kyoungjune Pak

Project Title: the association between amyloid deposition and obesity

Date: [153]

Request ID: D2014

Aim 1: to analyze the association between amyloid deposition by PET and obesity

Aim 2: to analyze the effect of Apo E genotyping on the association between amyloid deposition and obesity

Aim 3: to analyze the effect of aging on the association between amyloid deposition and obesity

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Investigator: Nicole S. McKay

Project Title: Harmonization and Validation of the Cognitive Batteries Administered Across the Knight ADRC Research Cohorts.

Date: [153]

Request ID: D2013

Aim 1: The main aim of this project is to harmonize the various cognitive batteries administered across the ADRC

Aim 2: Create one simple cognitive dataset that would allow comparisons across individuals who participated in different Knight ADRC studies

Aim 3: Evaluate how well the derived scores compare to traditional composites in classification of amyloid positive and negative individuals

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Investigator: Mary Jo LaDu

Project Title: APOE genotype frequencies and associated AD risk in African American, Afro-Caribbean, and African populations

Date: [153]

Request ID: D2012

Aim 1: Establish APOE genotype frequencies and relative risk for AD and cognitive decline in African American, Afro-Caribbean, African, and other African descendant populations via meta-analytic approaches.

Aim 2: Review literature for genetic variations and associated AD risk within the APOE gene cluster for individuals with African Ancestry.

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Investigator: Daniel Mroczek

Project Title: Personality Predictors of Dementia Onset and Progression: An Integrated Data Analysis

Date: [153]

Request ID: D2011

Aim 1: Examine whether baseline personality and indicators of psychological well-being (Positive Affect, Negative Affect) prospectively predict dementia onset.

Aim 2: Examine whether baseline personality and indicators of psychological well-being (Positive Affect, Negative Affect) prospectively disease progression (i.e. cognitive decline) following dementia diagnosis.

Aim 3: Use an integrated data analytic framework to investigate overall and sample-specific personality predictors of dementia onset and progression in six longitudinal studies.

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Investigator: Abhinav Jha

Project Title: Quantitative brain SPECT to measure severity of Parkinson’s disease

Date: [153]

Request ID: D2010

Aim 1: Develop and validate a new transmission-less attenuation compensation method for brain SPECT

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Investigator: Alison Goate

Project Title: Age extremes x APOE genotype sampling for genetic discovery in Alzheimer�s disease

Date: [153]

Request ID: D2009

Aim 1: Use multi-ethnic sequencing data from AD cases and cognitively normal controls to identify variants, genes, and genesets that protect against or accelerate disease

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Investigator: Jin-Tai Yu

Project Title: Genome-wide association study of brain amyloid and tau deposition

Date: [153]

Request ID: D2008

Aim 1: We aimed to do GWAS about different biomarkers in AD and other dementia disease, in order to find more meaningful SNPs

Aim 2: We aimed to explore the gene and protein undermine the SNPs about AD and other demential disease, especially about the amyloid and tau

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Investigator: Hongyu An

Project Title: PET/MR attenuation correction

Date: [153]

Request ID: D2007

Aim 1: To develop a deep learning based attenuation correct method for PET/MR imaging

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Investigator: Gagan S. Wig

Project Title: Examination of how changes in brain structure relates to changes in functional brain networks in adult individuals

Date: [153]

Request ID: D2006

Aim 1: examining whether increasing age is associated with changes in functional brain networks within individuals

Aim 2: determining whether an individual�s neuroanatomical changes relate to their functional brain network changes

Aim 3: determining whether age-associated cognitive changes can be explained by the joint influence of changes in brain anatomy and functional brain network organization

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