The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Phillip Hsu
Project Title: Risk factors associated with Headache due to Lumbar Puncture
Date: December 21, 2021 at 5:18 pm
Request ID: D1209
Aim 1: To identify risk factors that increase the likelihood of a post-Lumbar Puncture headache
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Investigator: Brooke Sadler
Project Title: The Evolutionary Role of Nicotinic Receptors in Memory and Cognitive Performance
Date: December 21, 2021 at 5:18 pm
Request ID: D1210
Aim 1: Examine association between genotypes in nicotinic receptors with phenotypes related to cognition
Aim 2: Determine if these genotypes are at different frequencies among AD vs non AD participants
Aim 3: Relate these frequency differences back to historical selective pressures on increased cognition
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Investigator: Charles DeCarli
Project Title: NACC MRI Genotype Association Studies
Date: December 21, 2021 at 5:18 pm
Request ID: D1211
Aim 1: Acquire MRI data related to TCV and Hippocampal estimates from NACC participating sites
Aim 2: Match MRI data with ADGC acquired genotype data on NACC enrolled subjects
Aim 3: Examine candidate gene associations from prior publications
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Investigator: Andrei Vlassenko
Project Title: Regional beta-amyloid deposition in cognitively normal older adults
Date: December 21, 2021 at 5:18 pm
Request ID: D1201
Aim 1: Examine regional differences in PIB BP in PIB-negative older compared to younger adults
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Investigator: Cruchaga Carlos
Project Title: Identification of rare variants implicated on Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1305
Aim 1: To identify and better understand the neuropathological findings for the PSEN1, p.E318G carriers
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Investigator: John C. Morris
Project Title: Investigating COMT and Intraindividual Variability
Date: December 21, 2021 at 5:18 pm
Request ID: D1304
Aim 1: Determine whether COMT is independently related to intraindividual variability in reaction time.
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Investigator: Beau Ances MD, PhD, MSc
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Date: December 21, 2021 at 5:18 pm
Request ID: D1303
Aim 1: To explore novel complex measures using multi-scale entropy in rs-fcMRI data from an HASD cohort.
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Investigator: Xiong Yunyun
Project Title: The association between PiB retention and cognitive decline
Date: December 21, 2021 at 5:18 pm
Request ID: D1301
Aim 1: a meta analysis investigating the prognostic value of baseline PiB status on the development of AD
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Investigator: Daniel Marcus
Project Title: Development of a tool for quantitative analysis of MRI and PET in clinical dementia
Date: December 21, 2021 at 5:18 pm
Request ID: D1223
Aim 1: NA (this is not a research project)
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Investigator: Yuan-Han,Yang
Project Title: ACE gene in AD with hypertension among African American and Caucasian American
Date: December 21, 2021 at 5:18 pm
Request ID: D1302
Aim 1: Examine the association of ACE gene in LOAD with / without hypertension in CA and AA
Aim 2: Examine the clinical course of LOAD in relation to their ACE indel polymorphism in CA and AA.
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