The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Paul Kotzbauer
Project Title: Testing the Synucleinopenia Hypothesis – Are Brain tissue Levels of Soluble Alpha-Synuclein Decreased in Parkinson Disease?
Date: December 19, 2024 at 11:23 am
Request ID: T2419 Kotzbauer
Aim 1: Determine whether levels of soluble α-syn measured in five cortical regions are lower in PD participants compared to control participants.
Aim 2: Determine whether levels of soluble α-syn correlate with levels of insoluble α-syn and also whether each of these measures correlates with motor and cognitive symptoms of PD.
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Investigator: Nicolas Barthelemy
Project Title: Unraveling the link between tau modifications, neuroinflammation and tauopathies
Date: December 13, 2024 at 5:56 pm
Request ID: T2418 Barthelemy
Aim 1: To evaluate the effect of CNS PAD enzymes on soluble and insoluble tau citrullination in brain from participants with AD and non-AD tauopathies
Aim 2: To explore potential relationship existing between brain tau abnormal phosphorylation and citrullination and evaluate how these abnormalities associate with tau aggregation in AD and non-AD tauopathies
Aim 3: To evaluate the impact of 3R+4R tau pathology on the specificity of biomarker candidate of astrocytic tau pathology
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Investigator: Partha Dutta
Project Title: The role of microglia in cognitive impairment in patients with myocardial infarction
Date: October 15, 2024 at 10:21 am
Request ID: T2417 Dutta
Aim 1: To correlate mircoglial epigenetic modifiers with cognitive functin after myocardial infarction
Aim 2: To assess hippocampal microglia-neuron crosstalk in patients with myocardial infarction
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Investigator: Hongyu AN
Project Title: Neuroinflammation in Cerebral Small Vessel Disease using PET/MR Imaging
Date: October 15, 2024 at 9:51 am
Request ID: T2302-A
Aim 1: Determine if S1PR1 expression increases and colocalizes with microglia and astrocytes in post-mortem brain specimens from deceased patients with underlying CSVD.
Aim 2: Determine if neuroinflammation measured by 11C-CS1P1 uptake is independently associated with CSVD structural endpoints using in vivo PET/MR imaging.
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Investigator: Heleen Verlinden
Project Title: Comprehensive analysis of cellular responses to Alzheimer’s and comorbid pathologies
Date: September 13, 2024 at 4:54 am
Request ID: T2416
Aim 1: To identify the cellular transcriptional changes to AD pathology in the superior frontal gyrus of postmortem human brains.
Aim 2: We aim to identify the cellular transcriptional changes to amyloid plaques without tau pathology compared to amyloid-associated tau pathology. This will help to refine the mechanism resolving amyloid stress or preventing amyloid-induced tau pathology.
Aim 3: Our overall aim is to identify new medicines to preserve cognition and other brain functions, enhance resilience to disease pathology, and slow or stop the progression of neurodegenerative diseases.
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Investigator: Meredith Jackrel and Jennifer Heemstra
Project Title: RNA editing in ADRD
Date: September 8, 2024 at 2:09 pm
Request ID: T2415
Aim 1: Understanding the effects of protein misfolding on A-to-I RNA editing and RNA localization in ADRD.
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Investigator: Henry Houlden
Project Title: Investigating the transcriptomic and genomic profiles of rare neurodegenerative disorders
Date: August 22, 2024 at 6:08 am
Request ID: T2414
Aim 1: Generate paired long-read DNA and RNA-seq data in each case
Aim 2: RNA expression of disease gene (and repeat expansion sizes) will differ in brain regions
Aim 3: Use this genomic and transcriptomic map to re-assess the pathogenicity of variants
Aim 4: Clinical correlation of expression differences and repeat expansion sizes in brain tissue
Investigator: Marco Colonna (PI) and Naresha Saligrama (Co-I)
Project Title: Spontaneous and Induced B cell and T cell responses in Alzheimer’s Disease
Date: August 6, 2024 at 1:28 pm
Request ID: T2413
Aim 1: Aim 1 will determine repertoires of Aβ- and Tau-specific B cells derived from different lymphopoietic sites.
Aim 2: Aim 2 will determine the impact of the site of injection and adjuvants in active immunization against Aβ and Tau.
Aim 3: Aim 3 will determine T cell and B cell responses to Aβ and Tau in human AD.
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Investigator: Kanekiyo, Ulrich
Project Title: Lipid signature in cerebrospinal fluid predicting the risk for cognitive impairment in the elderly
Date: July 22, 2024 at 11:49 am
Request ID: T2412
Aim 1: Assess lipiomic profile in CSF using shotgun lipidomic analysis
Aim 2: Correlate lipidomic species with AD fluid biomarkers and cognitive status
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Investigator: Holtzman
Project Title: Using CO-detection by inDEXing (CODEX) multiplexed tissue imaging to assess immune and glial cell profiles in AD brain tissue
Date: May 17, 2024 at 3:16 pm
Request ID: T2411
Aim 1: Perform pilot staining of AD and non-AD brain sections for proof-of-feasibility
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