The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Oscar Harari
Project Title: Mendelian randomization for unbiased biomarker discovery for AD and other complex traits
Date: December 21, 2021 at 5:02 pm
Request ID: T1727
Aim 1: To identify common and rare genetic variants and pathways associated with protein levels in plasma, CSF and brain tissue
Aim 2: To determine whether the variants associated with plasma, CSF and brain protein levels are also associated with AD or other complex traits
Aim 3:
Aim 4:
Investigator: Dominique Campion
Project Title: Investigate of the pathophysiological mechanisms driven by the MAPT duplication
Date: December 21, 2021 at 5:02 pm
Request ID: T1726
Aim 1: Identification of novel MAPT duplication carriers: targeted screening of the MAPT gene duplication by QMPSF
Aim 2:
Aim 3:
Aim 4:
Investigator: Brian Gordon and Meghan Campbell
Project Title: Comparing novel biomarkers in Alzheimer and Parkinson diseases
Date: December 21, 2021 at 5:02 pm
Request ID: T1923
Aim 1: Explore what biomarker profiles differentiate AD and PD cohorts
Aim 2: Relate biomarkers to clinical presentation in both AD and PD cohorts
Aim 3: Compare CSF and plasma NfL measures
Aim 4:
Investigator: Charles Glabe
Project Title: The identification of an antibody or antibodies that serve as AD biomarkers
Date: December 21, 2021 at 5:02 pm
Request ID: T1922
Aim 1: Screen plasma or serum for amyloid antibodies using a protein sequence array
Aim 2:
Aim 3:
Aim 4:
Investigator: David Holtzman
Project Title: Validation of novel human apoE antibody staining in human AD and CAA tissue
Date: December 21, 2021 at 5:02 pm
Request ID: T1921
Aim 1: To determine whether a novel anti-human apoE antibody with therapeutic potential binds amyloid plaques in human AD and CAA tissue
Aim 2: To quantify the proportion of anti-human apoE antibody binding to apoE in parenchymal plaques compared to CAA
Aim 3:
Aim 4:
Investigator: Gregory J. Zipfel
Project Title: Impact and Mechanisms of Vascular Oxidative Stress on CAA Pathogenesis and CAA-Related Dementia
Date: December 21, 2021 at 5:02 pm
Request ID: T1919
Aim 1: Correlate HSPG expression with NADPH oxidase activity, vascular oxidative stress, altered LRP1 and oxidized-LRP1 levels, and CAA in cerebral vessels of Alzheimer’s and non-Alzheimer’s autopsy samples
Aim 2: Correlate NADPH oxidase activity with vascular oxidative stress, altered LRP1 and oxidized-LRP1 expression, and CAA load in cerebral vessels of Alzheimer’s and non-Alzheimer’s autopsy samples
Aim 3:
Aim 4:
Investigator: Marc Diamond
Project Title: Analysis of tau strain types familial Alzheimer’s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1819
Aim 1: Analysis of tau strain types in cases of familial Alzheimer’s Disease (FAD) using a panel of cellular biosensors
Aim 2: Comparison of the seeding data from tau strain(s) identified in FAD data to cases of sporadic Alzheimer’s Disease
Aim 3:
Aim 4:
Investigator: Joel S Perlmutter
Project Title: Imaging VAChT in Parkinson disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1820
Aim 1: identify postmortem correlation between PET findings and autopsy findings of VAChT in brain
Aim 2:
Aim 3:
Aim 4:
Investigator: Zhude Tu
Project Title: PET PROBES FOR IMAGING THE VESICULAR ACETYLCHOLINE TRANSPORTER
Date: December 21, 2021 at 5:02 pm
Request ID: T1818 Liu
Aim 1: Determine the feasibility of quantitative VAChT imaging in patients with PSP-RS
Aim 2:
Aim 3:
Aim 4:
Investigator: Gilbert Gallardo
Project Title: Targeting Reactive Astrocytes for Therapeutic Intervention of Alzheimer�s Disease
Date: December 21, 2021 at 5:02 pm
Request ID: T1920
Aim 1: The purpose of this tissue request is to test our hypothesis that the astrocytic α2-NKA and related genes are elevated in Alzheimer�s disease patients.
Aim 2:
Aim 3:
Aim 4: