The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Zachary McEachin
Project Title: Assessment of cryptic exons in TDP-43 proteinopathies
Date: [208]
Request ID: T2301
Aim 1: Determine the abundance of cryptic exons across FTLD-TDP subtypes
Aim 2: Determine the proteomic signatures associated with distinct TDP-43 subtypes
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Investigator: Hongyu An
Project Title: Neuroinflammation in Cerebral Small Vessel Disease using PET/MR Imaging
Date: [208]
Request ID: T2302
Aim 1: Determine if S1PR1 expression increases and colocalizes with microglia and astrocytes in post-mortem brain specimens from deceased patients with underlying CSVD.
Aim 2: Determine if neuroinflammation measured by 11C-CS1P1 uptake is independently associated with CSVD structural endpoints using in vivo PET/MR imaging.
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Investigator: Randall Bateman
Project Title: Evaluation of peripheral apoE protein levels as a function of CNS amyloidosis development in a Knight ADRC cohort.
Date: [208]
Request ID: T2303
Aim 1: Assess the timing of changes in peripheral apoE protein levels as a function of CNS amyloidosis development.
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Investigator: Andrew Kraft / Evan Macosko
Project Title: Cellular mechanics of white matter disease
Date: [208]
Request ID: T2304
Aim 1: Determine spatial heterogeneity in healthy WM cell type composition and gene expression.
Aim 2: Identify the selective cellular vulnerabilities that define cerebral small vessel disease- and Alzheimer disease-related WMD
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Investigator: Jonathan Kipnis
Project Title: Continuous perivascular space allows brain macromolecules efflux to the dura mater
Date: [208]
Request ID: T2305
Aim 1: Define arteriovenous overlaps in the human leptomeninges.
Aim 2: Determine the ultrastructure of arteriovenous overlaps of non-dementia and Alzheimer’s disease patients.
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Investigator: Qing Wang
Project Title: Association of CSF sTREM2 and plasma GFAP with an MRI measure of neuroinflammation
Date: [208]
Request ID: T2306
Aim 1: Compare DBSI neuroinflammation index to in vivo CSF and plasma inflammation biomarkers (sTREM2 and GFAP) in the Knight ADRC cohorts
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Investigator: Day
Project Title: Biomarkers and Rates of Progression in Dementia (Bio-RaPID)
Date: [208]
Request ID: T2307
Aim 1: Define the “cellular contributors” to RPD, addressing the key question of what makes patients vulnerable to rapidly progressive dementia
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Investigator: David Holtzman
Project Title: Evaluating the ability of gut microbiota to promote neuroinflammation and tau pathology
Date: [208]
Request ID: T2308
Aim 1: Determine how the human AD microbiome impacts tau pathology, neuroinflammation, and neurodegeneration in a germ-free model of tau-mediated neurodegeneration
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Investigator: Carlos Cruchaga
Project Title: Large scale gene discovery for neurological traits
Date: [208]
Request ID: T2309
Aim 1: To generate WES for all the Knight-ADRC samples
Aim 2: To identify variants and genes associated with AD and ADRD
Aim 3: To determine the genetic overlap between AD, PD and other neurological traits
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Investigator: gregory wu
Project Title: MOG antibodies in neurodegenerative diseases
Date: [208]
Request ID: T2310
Aim 1: Determine the prevalence and titer of circulating MOG antibodies in patients with AD
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