The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: John C. Morris
Project Title: Investigating COMT and Intraindividual Variability
Date: December 21, 2021 at 5:18 pm
Request ID: D1304
Aim 1: Determine whether COMT is independently related to intraindividual variability in reaction time.
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Investigator: Cruchaga Carlos
Project Title: Identification of rare variants implicated on Alzheimer’s Disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1305
Aim 1: To identify and better understand the neuropathological findings for the PSEN1, p.E318G carriers
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Investigator: Adam Ingber
Project Title: Reserve variables and the relationship between AD biomarkers and non-cognitive outcomes
Date: December 21, 2021 at 5:18 pm
Request ID: D1306
Aim 1: To examine how cognitive and brain reserve measures mediate associations between AD biomarkers and n
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Investigator: B. Joy Snider
Project Title: Role of Cerebrospinal fluid studies in Diagnosis and Treatment of Dementing Disorders at MDC
Date: December 21, 2021 at 5:18 pm
Request ID: D1308
Aim 1: Characterize patients selected for CSF analysis as part of dementia evaluation
Aim 2: Determine if CSF results, specifically disease-related biomarkers, change diagnosis or treatment
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Investigator: Kathleen Vernon
Project Title: Lateralization of Atrophy and Behavioral Disturbance in AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1309
Aim 1: Determine if lateralized brain atrophy in mild AD is related to types of behavioral disturbance.
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Investigator: Terrance Kummer
Project Title: Axon injury in intracerebral hemorrhage
Date: December 21, 2021 at 5:18 pm
Request ID: D1310
Aim 1: Determine the extent of local and global acute axonal injury after ICH using diffusion tensor imagin
Aim 2: Examine the sub-acute evolution of local and global axonal injury following ICH
Aim 3: Examine the chronic evolution of local and global axonal injury after ICH, and determine which is be
Aim 4: Compare radiological biomarkers of axonal injury resulting from ICH with biochemical biomarkers obta
Investigator: JC Morris
Project Title: PIB negative but cognitively impaired
Date: December 21, 2021 at 5:18 pm
Request ID: D1312
Aim 1: Evaluate possible reasons for the discordance between clinical status and imaging biomarker status
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Investigator: Grant – John C. Morris, MD. This project – Jennifer Phillips
Project Title: Factors Influencing Assent for Brain Donation
Date: December 21, 2021 at 5:18 pm
Request ID: D1313
Aim 1: To examine data from the past ten years and determine the time that participants are most likely to
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Investigator: Yaakov Stern
Project Title: A new prediction algorithm for mortality and nursing home admission.
Date: December 21, 2021 at 5:18 pm
Request ID: D1314
Aim 1: To validate a prediction algorithm.
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Investigator: Anne Fagan and Maartje Kester
Project Title: APOE genotype and CSF biomarkers in predictive models for cognitive decline and Alzheimer’s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1315
Aim 1: to look at the effect of APOE genotype on the diagnostic and prognostic ability of CSF biomarkers.
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