The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Alison Goate
Project Title: TOMM40 and neuroimaging phenotypes
Date: [153]
Request ID: D1111
Aim 1: Test hypothesis from Mark Sager regarding relationship between TOMM40 genotypes and neuroimaging phe
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Investigator: Alison Goate
Project Title: Genetics of CSF endophenotypes for AD
Date: [153]
Request ID: D1110
Aim 1: To identify genes that influence the CSF levels of AD biomarkers
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Investigator: John C Morris
Project Title: Multimodal biomarker prediction
Date: [153]
Request ID: D1109
Aim 1: Evaluate biomarker combinations that predict clinical outcomes in cognitively normal and DAT persons
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Investigator: Mark McDaniel
Project Title: The Effects of Hypertension and Abnormal Blood Pressure on Prospective Memory
Date: [153]
Request ID: D1108
Aim 1: Assess the effects of hypertension on focal versus nonfocal prospective memory (PM) performance
Aim 2: Determine whether gray matter volume mediates the relationship between hypertension and PM
Aim 3: Determine whether white matter integrity relates to focal PM, nonfocal PM, or hypertension
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Investigator: Jason Hassenstab
Project Title: Obesity, Insulin Sensitivity, and Functional Connectivity in Normal Aging
Date: [153]
Request ID: D1107
Aim 1: Do CDR 0’s with obesity and insulin resistance perform poorly on memory and executive function?
Aim 2: Do CDR 0’s with obesity and insulin resistance have reduced functional connectivity?
Aim 3: Do CDR 0’s with obesity and insulin resistance have lower brain volumes/cortical thickness?
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Investigator: Jonathan Day
Project Title: Assessment of Current Alzheimer’s Disease Therapies Using Neuroimaging and CSF Biomarkers: A Pilot S
Date: [153]
Request ID: D1106
Aim 1: Assess the effectiveness of AD therapies from a neuroimaging and biomarker standpoints
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Investigator: Catherine M. Roe
Project Title: IMPROVING PRESYMPTOMATIC DETECTION OF IMPENDING ALZHEIMER’S DISEASE
Date: [153]
Request ID: D1105
Aim 1: To examine how cognitive and brain reserve factors combine with AD biomarkers
Aim 2: To build biomarker models that yield individual risk profiles predicting the time of AD onset.
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Investigator: Dr. John Morris
Project Title: Age of Onset Disparities among first degree relatives
Date: [153]
Request ID: D1104
Aim 1: To determine the causes for AOO disparities among first degree relatives
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Investigator: Luigi Maccotta
Project Title: Functional Connectivity in Epilepsy
Date: [153]
Request ID: D1103
Aim 1: To characterize changes in local and long-range functional connections in temporal lobe epilepsy
Aim 2: To characterize connectivity changes in TLE patients with grossly normal brain anatomy
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Investigator: Dr. Denise Head
Project Title: Effects of the BDNF polymorphism and exercise on brain structure, AD biomarkers and cognition.
Date: [153]
Request ID: D1102
Aim 1: examine the effects of the BDNF polymorphism on brain, cognition, and AD biomarkers
Aim 2: examine interactions between the BDNF polymorphism and exercise
Aim 3: examine interactions between the BDNF polymorphism and age
Aim 4: examine interactions between the APOE and BDNF polymorphisms