The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Yvette Sheline
Project Title: Hippocampal subfield segmentation comparison in LLD, AD and controls
Date: [153]
Request ID: D1131
Aim 1: 1) Compared with controls, patients with LLD will have smaller hippocampal subfield volumes in denta
Aim 2: 2) LLD patients will have progression in CA2-3 volume loss related to interim perceived stress durin
Aim 3: 3) Compared with controls, CDR = 0.5 participants will have significantly hippocampal volunes, parti
Aim 4: 4) Across all groups DG volumes will correlate inversely with MCBP on PIB PET
Investigator: Sandra Chapman
Project Title: Early Markers of Language Dissolution in HDDD2
Date: [153]
Request ID: D1130
Aim 1: Explore relationshp between language and clinical/genetic profiles of HDDD cohort
Aim 2: Examine changes in discoures measures for individuals rested in follow-up
Aim 3: Explore relationship between changes in disourse and performance on neuropsych
Aim 4:
Investigator: Melanie Bauer
Project Title: Relation between Working Memory, Long-Term Memory, and Fluid Intelligence
Date: [153]
Request ID: D1129
Aim 1: Examine relationships between areas of cognition: working and long-term memory & fluid intelligence
Aim 2: These relationships will be compared in healthy and cognitively impaired older adults.
Aim 3: If possible, longitudinal changes in memory will be compared to changes in fluid intelligence
Aim 4:
Investigator: Danny JJ Wang
Project Title: Complexity and synchronicty of resting state fMRI time-series in Alzheimer’s disease
Date: [153]
Request ID: D1128
Aim 1: To quantify the complexity of resting fMRI using ApEn in AD, MCI and NC subjects
Aim 2: To quantify the asynchrony of resting fMRI using C-ApEn and compare with cross-correlation
Aim 3:
Aim 4:
Investigator: Brian Carpenter
Project Title: Ability of Collateral Informants to Describe Patient Functioning
Date: [153]
Request ID: D1127
Aim 1: Determine the base rate of collaterals who are rated as having questionable or poor accuracy
Aim 2: Determine the base rate of reasons for collateral inaccuracy
Aim 3:
Aim 4:
Investigator: David Holtzman
Project Title: Clinicopathologic Characterization of Late-Onset Autosomal Dominant AD
Date: [153]
Request ID: D1126
Aim 1: Identify clinical charactersitics of family LO6 who harbor PSEN1 A79V mutations
Aim 2: Examine CSF and Imaging biomarkers in individuals from family LO6
Aim 3: Compare clinical and biomarker data between LO6 and early-onset kindreds with PSEN1 A79V mut
Aim 4:
Investigator: Carlos Cruchaga/Alison Goate
Project Title: To test whether the poly-T polymorphism (rs10524523) is associated with change in gray matter volume
Date: [153]
Request ID: D1125
Aim 1: Try to replicate the Dr. Sager neuroimaging findings in a larger series
Aim 2:
Aim 3:
Aim 4:
Investigator: David Holtzman/Alison Goate
Project Title: To identify genetic variation that influences VILIP1 levels in cerebrospinal fluid
Date: [153]
Request ID: D1124
Aim 1: To identify polymorphisms that explain variability in CSF VILIP1 levels.
Aim 2:
Aim 3:
Aim 4:
Investigator: Denise Head
Project Title: The Relationship Between Stress and Biomarkers of Alzheimer’s Diseases
Date: [153]
Request ID: D1123
Aim 1: To determine the relationship between stress exposure and AD biomarkers
Aim 2: To investigate whether stress exacerbates the effects of age on AD biomarkers
Aim 3: To examine whether stress exacerbates the effects of APOE e4 and/or met-BDNF allele on AD biomarkers
Aim 4: To examine the interaction effect between stress and exercise on AD biomarkers
Investigator: Joanne Conover
Project Title: Ventricular Expansion and Leakiness in Normal Aging
Date: [153]
Request ID: D1122
Aim 1: Regional Trends in Expansion and Hyperintensities Using FLAIR-MRI
Aim 2:
Aim 3:
Aim 4: