The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Chengjie Xiong
Project Title: Wavelet-based statistical analysis on brain functional connectivity
Date: December 21, 2021 at 5:18 pm
Request ID: D1222
Aim 1: Develop novel quantitative tools to comprehensively measure brain functional connectivity
Aim 2: Develop novel stat. methods to identify impairments of brain func. connectivity in elderly individua
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Investigator: Alison Goate
Project Title: Clinicopathological correlations of MAPT A152T mutation carriers
Date: December 21, 2021 at 5:18 pm
Request ID: D1213
Aim 1: Characterize clinical phenotype of MAPT A152T mutation carriers
Aim 2: Characterize pathological phenotype of MAPT A152T mutation carriers
Aim 3: Characterize molecular phenotype of MAPT A152T mutation carriers
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Investigator: Rachel Chasse
Project Title: Enhancing Normative Cognitive Data with Information from Biomarkers and Neuroimaging.
Date: December 21, 2021 at 5:18 pm
Request ID: D1214
Aim 1: Assemble a normative cognitive database informed by biomarker evidence of AD neuropathology.
Aim 2: Determine if this ‘super’ normative database will improve early detection of cognitive decline.
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Investigator: Catherine M. Roe
Project Title: Use of Alzheimer’s Disease Biomarkers to Predict Longevity and Disability
Date: December 21, 2021 at 5:18 pm
Request ID: D1215
Aim 1: To examine whether AD biomarker levels in cognitively normal persons predict longevity and disabilit
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Investigator: Napatkamon Ayutyanont
Project Title: Development of Composite Cognitive Endpoints for Presymptomatic AD Trials
Date: December 21, 2021 at 5:18 pm
Request ID: D1216
Aim 1: To refine composite endpoints previously developed to track cognitive changes leading to onset of AD
Aim 2: To establish generalizability of the implicated composite endpoint in other longitudinal datasets
Aim 3: To provide prelim. sample size estimates for proposed presymptomatic AD trials (API’s, ADCS’s, etc.)
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Investigator: Beau Ances MD, PhD
Project Title: The Effects of Autosomal Dominant and Sporadic Alzheimer Disease on Intra and Inter-Network Resting
Date: December 21, 2021 at 5:18 pm
Request ID: D1217
Aim 1: We will assess participants with (M+) and siblings without (M-) adAD mutations that are followed in
Aim 2: We will compare these individuals to participants from multiple studies conducted at the Knight Alzh
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Investigator: Tae Sung Lim
Project Title: A corticobasal degeneration case mimicking Alzheimer’s disease
Date: December 21, 2021 at 5:18 pm
Request ID: D1218
Aim 1: Determine the clinical characteristics of CBD case mimicking AD
Aim 2: Clinicopathological correlation of CBD case mimicking AD
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Investigator: Robert Koeppe
Project Title: Standardizing Biomarker Reporting for Amyloid Plaque Estimation by PET
Date: December 21, 2021 at 5:18 pm
Request ID: D1220
Aim 1: To provide a standard method for quantifying scaling of amyloid burden with PET
Aim 2: The quantification scale would be applicable to different radiotracers
Aim 3: The quantification scale would be applicable to different analysis methods
Aim 4: Methods for conversion of SUVr or DVR results into the standard scale will be developed
Investigator: Gina D’ANgelo
Project Title: Groupwise approaches for functional connectivity
Date: December 21, 2021 at 5:18 pm
Request ID: D1219
Aim 1: develop population-level inter-regional approaches for resting-state fMRI
Aim 2: develop population-level network approaches for resting-state fMRI
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Investigator: JC Morris
Project Title: Testing the hypothesized stages of pre-clinical AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1221
Aim 1: Identify the NIA-AA stages of preclinical AD by CSF markers in cognitively normal individuals
Aim 2: Investigate the predictive accuracy of these stages for cognitive and clinical decline
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