The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Gina D’ANgelo
Project Title: Groupwise approaches for functional connectivity
Date: [153]
Request ID: D1219
Aim 1: develop population-level inter-regional approaches for resting-state fMRI
Aim 2: develop population-level network approaches for resting-state fMRI
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Investigator: Robert Koeppe
Project Title: Standardizing Biomarker Reporting for Amyloid Plaque Estimation by PET
Date: [153]
Request ID: D1220
Aim 1: To provide a standard method for quantifying scaling of amyloid burden with PET
Aim 2: The quantification scale would be applicable to different radiotracers
Aim 3: The quantification scale would be applicable to different analysis methods
Aim 4: Methods for conversion of SUVr or DVR results into the standard scale will be developed
Investigator: Tae Sung Lim
Project Title: A corticobasal degeneration case mimicking Alzheimer’s disease
Date: [153]
Request ID: D1218
Aim 1: Determine the clinical characteristics of CBD case mimicking AD
Aim 2: Clinicopathological correlation of CBD case mimicking AD
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Investigator: Beau Ances MD, PhD
Project Title: The Effects of Autosomal Dominant and Sporadic Alzheimer Disease on Intra and Inter-Network Resting
Date: [153]
Request ID: D1217
Aim 1: We will assess participants with (M+) and siblings without (M-) adAD mutations that are followed in
Aim 2: We will compare these individuals to participants from multiple studies conducted at the Knight Alzh
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Investigator: Napatkamon Ayutyanont
Project Title: Development of Composite Cognitive Endpoints for Presymptomatic AD Trials
Date: [153]
Request ID: D1216
Aim 1: To refine composite endpoints previously developed to track cognitive changes leading to onset of AD
Aim 2: To establish generalizability of the implicated composite endpoint in other longitudinal datasets
Aim 3: To provide prelim. sample size estimates for proposed presymptomatic AD trials (API’s, ADCS’s, etc.)
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Investigator: Catherine M. Roe
Project Title: Use of Alzheimer’s Disease Biomarkers to Predict Longevity and Disability
Date: [153]
Request ID: D1215
Aim 1: To examine whether AD biomarker levels in cognitively normal persons predict longevity and disabilit
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Investigator: Rachel Chasse
Project Title: Enhancing Normative Cognitive Data with Information from Biomarkers and Neuroimaging.
Date: [153]
Request ID: D1214
Aim 1: Assemble a normative cognitive database informed by biomarker evidence of AD neuropathology.
Aim 2: Determine if this ‘super’ normative database will improve early detection of cognitive decline.
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Investigator: Alison Goate
Project Title: Clinicopathological correlations of MAPT A152T mutation carriers
Date: [153]
Request ID: D1213
Aim 1: Characterize clinical phenotype of MAPT A152T mutation carriers
Aim 2: Characterize pathological phenotype of MAPT A152T mutation carriers
Aim 3: Characterize molecular phenotype of MAPT A152T mutation carriers
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Investigator: Alison Goate/Oscar Harari
Project Title: Identification of genetic factors associated with rate of progression
Date: [153]
Request ID: D1212
Aim 1: To replicate the association of rs1868402 with rate of progression
Aim 2: To analyze whether other genetic factors associated with CSF ptau181 levels
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Investigator: Charles DeCarli
Project Title: NACC MRI Genotype Association Studies
Date: [153]
Request ID: D1211
Aim 1: Acquire MRI data related to TCV and Hippocampal estimates from NACC participating sites
Aim 2: Match MRI data with ADGC acquired genotype data on NACC enrolled subjects
Aim 3: Examine candidate gene associations from prior publications
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