The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: JC Morris
Project Title: Testing the hypothesized stages of pre-clinical AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1221
Aim 1: Identify the NIA-AA stages of preclinical AD by CSF markers in cognitively normal individuals
Aim 2: Investigate the predictive accuracy of these stages for cognitive and clinical decline
Aim 3:
Aim 4:
Investigator: Denise Head
Project Title: The Relationship Between Stress and Biomarkers of Alzheimer’s Diseases
Date: December 21, 2021 at 5:18 pm
Request ID: D1123
Aim 1: To determine the relationship between stress exposure and AD biomarkers
Aim 2: To investigate whether stress exacerbates the effects of age on AD biomarkers
Aim 3: To examine whether stress exacerbates the effects of APOE e4 and/or met-BDNF allele on AD biomarkers
Aim 4: To examine the interaction effect between stress and exercise on AD biomarkers
Investigator: Alison Goate
Project Title: Genetics of CSF endophenotypes for AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1110
Aim 1: To identify genes that influence the CSF levels of AD biomarkers
Aim 2:
Aim 3:
Aim 4:
Investigator: Alison Goate
Project Title: TOMM40 and neuroimaging phenotypes
Date: December 21, 2021 at 5:18 pm
Request ID: D1111
Aim 1: Test hypothesis from Mark Sager regarding relationship between TOMM40 genotypes and neuroimaging phe
Aim 2:
Aim 3:
Aim 4:
Investigator: Siekyeong Kim
Project Title: Relationship of Cortical Thickness to Brain Morphology and Body Size
Date: December 21, 2021 at 5:18 pm
Request ID: D1113
Aim 1: What is the relationship between cortical thickness and head size?
Aim 2: Are there differences in the above relationship by CDR status?
Aim 3:
Aim 4:
Investigator: Bruno M. Jedynak
Project Title: Statistical Analysis of the Progression of AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1114
Aim 1: Validate the findings from ADNI data using ADRC data
Aim 2:
Aim 3:
Aim 4:
Investigator: Joel Perlmutter
Project Title: Effects of Parkinson’s Disease on BOLD Functional Connectivity
Date: December 21, 2021 at 5:18 pm
Request ID: D1118
Aim 1: Study effects of PD on BOLD FC in subcortical areas
Aim 2:
Aim 3:
Aim 4:
Investigator: Joanne Conover
Project Title: Ventricular Expansion and Leakiness in Normal Aging
Date: December 21, 2021 at 5:18 pm
Request ID: D1122
Aim 1: Regional Trends in Expansion and Hyperintensities Using FLAIR-MRI
Aim 2:
Aim 3:
Aim 4:
Investigator: James Galvin
Project Title: Utility of the AD8 in Mild Cognitive Impairment
Date: December 21, 2021 at 5:18 pm
Request ID: D1112
Aim 1: Determine the psychometric properties of the AD8 to discriminate MCI from healthy controls
Aim 2:
Aim 3:
Aim 4:
Investigator: John C. Morris
Project Title: Correlation of AD biomarkers with CDR 0.5 diagnoses
Date: December 21, 2021 at 5:18 pm
Request ID: D1115
Aim 1: Correlate PIB retention with CDR 0.5 diagnoses
Aim 2: Correlate CSF levels of Abeta and tau with CDR 0.5 diagnoses
Aim 3: Correlate nWBV and hippocampal volume with CDR 0.5 diagnoses
Aim 4: Correlate pyschometric performance with CDR 0.5 diagnoses