The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Jennifer Molano
Project Title: The Effect of Alzheimer’s Disease Biomarkers and Sleep on Cognitive Performance
Date: [153]
Request ID: D1402
Aim 1: CSF levels of Aβ42, tau, ptau181, tau/Aβ42, and ptau181/Aβ42 indicating AD pathology will be associated with worse psychometric performance on tests of memory and/or executive functioning among cognitively normal adults, both cross-sectionally and longitudinally.
Aim 2: Sleep efficiency will be an effect modifier on psychometric scores, with worse sleep efficiency correlating with worse psychometric performance on tests of memory and/or executive functioning cross-sectionally and longitudinally, after accounting for any effect of CSF AD biomarkers. termine if
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Investigator: Ien Li
Project Title: Patch-Based Analysis of Anatomical Brain Asymmetry
Date: [153]
Request ID: D1401
Aim 1: Compare structural hemispheric brain asymmetry patterns in diseased individuals versus healthy controls
Aim 2: Assess cognitive measures with brain asymmetry from structural MRI scans
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Investigator: Denise Head
Project Title: Cognitive profiles in the Adult Children Study
Date: [153]
Request ID: D1325
Aim 1: Confirm the the latent factor structure of the psychometric battery for the Adult Children Study
Aim 2: Test potential differences in factor structure based on family history of AD
Aim 3: Test potential differences in factor structure based on APOE status
Aim 4: Test potential differences in factor structure based on age
Investigator: Catherine Roe
Project Title: Use of Alzheimer’s Disease Biomarkers to Predict UPDRS Symptoms
Date: [153]
Request ID: D1324
Aim 1: To examine the extent to which AD biomarker levels in cognitively normal persons predict PD symptoms
Aim 2: to examine the extent to which AD biomarkers predict rate of change of parkinsonian symptoms in individuals with AD at baseline.
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Investigator: John C Morris
Project Title: Examine neuropathological correlates of subjective memory complaints
Date: [153]
Request ID: D1323
Aim 1: . Describe the relationship between main neuropathological findings of Alzheimer’s disease (β-amyloi
Aim 2: Clarify the role of the accompanying neuropathological findings (white matter change, ischemia, infa
Aim 3: Determine what neuropathological finding is the best candidates to explain SMC.
Aim 4: Compare other clinical and biological variables (CDR-SB, ApoE,) between participants with or without
Investigator: John C Morris
Project Title: Crossed Alexia without Agraphia in Progressive Posterior Cortical Dysfunction caused by Alzheimer’s
Date: [153]
Request ID: D1322
Aim 1: Report the first case of pathologically proven crossed alexia without agraphia in a posterior cortic
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Investigator: JC Morris
Project Title: Validation of the AD8
Date: [153]
Request ID: D1321
Aim 1: Determine AD8 scores for all participants at baseline since Sept 2005 who later came to autopsy
Aim 2: Correlate AD8 positive and AD8 negative individuals with neuropathological diagnoses
Aim 3: Correlate AD8 scores with subjective memory complaints
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Investigator: Carlos Cruchaga
Project Title: Identification of genetic variants associated with AD progression rate
Date: [153]
Request ID: D1320
Aim 1: Psychometric scores from the different test and contributed sites will be combined
Aim 2: A GWAS will be running using several psychometric test as endophentypes
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Investigator: CAMD consortium
Project Title: CAMD request for biomarker data
Date: [153]
Request ID: D1319
Aim 1: FDA biomarker qualification
Aim 2: Alzheimer’s disease progression modeling
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Investigator: Stephanie Vos
Project Title: Prevalence of amyloid pathology in healthy and cognitively impaired individuals
Date: [153]
Request ID: D1318
Aim 1: To characterize amyloid prevalence according to baselin cognitive scores (CDR, MMSE, delayed recall)
Aim 2: To characterize amyloid prevalence according to age, apoE genotype
Aim 3: To characterize amyloid prevalence according to future cognitive scores (CDR, MMSE, delayed recall)
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