The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Carlos Cruchaga
Project Title: To identify genetic variation that influences YKL40 levels in cerebrospinal fluid
Date: [153]
Request ID: D1412
Aim 1: To identify genetic variation that influences YKL40 levels in cerebrospinal fluid
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Investigator: Catherine Roe
Project Title: Alzheimer’s Disease: AD Biomarkers and Lipids
Date: [153]
Request ID: D1411
Aim 1: To examine the cross-sectional and longitudinal associations between lipids levels in the plasma and AD, dementia, and CSF AD biomarkers, including Aβ42, tau, and ptau181.
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Investigator: Denise Head
Project Title: Effects of the mineralocorticoid receptor polymorphisms and plasma cortisol on brain structure, cognition and personality
Date: [153]
Request ID: D1410
Aim 1: To examine the effect of the two single nucleotide polymorphisms in the mineralocorticoid receptor on brain structure, cognition and neuroticism
Aim 2: To examine whether the mineralocorticoid receptor genotypes interact with plasma cortisol
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Investigator: Sebastian Palmqvist, MD, PhD
Project Title: Comparison of large cohorts examining AD biomarkers
Date: [153]
Request ID: D1409
Aim 1: Verify the number of patients that have undergone CSF, PET, MRI, and examine the follow-up time and inclusion/exclusion procedures
Aim 2: Compare this to other large cohorts such as AiBL, ADNI, Descripa among others.
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Investigator: jason Hassenstab
Project Title: Staging Preclinical AD With the Free and Cued Selective Reminding Test
Date: [153]
Request ID: D1408
Aim 1: To operationalize the “subtle cognitive deficits” that define Stage 3 preclinical AD
Aim 2: To determine if the FCSRT+IR is an optimal measure to predict progression to symptomatic AD
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Investigator: Carlos Cruchaga
Project Title: Identification of novel genes and variants associated with Alzheimer’s disease and other complex traits by using CSF and plasma analytes levels as quantitative traits
Date: [153]
Request ID: D1407
Aim 1: To identify common genetic variants associated with CSF and plasma protein levels
Aim 2: To identify low-frequency coding variants and genes associated with CSF plasma protein levels
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Investigator: John C. Morris
Project Title: Association of Lewy Body Pathology with UPDRS Motor Scores, Neuropsychiatric Symptoms, and Depression Scores among Persons with Neuropathological AD
Date: [153]
Request ID: D1406
Aim 1: To examine the associations between Lewy Body pathology and motor, neuropsychiatric, and depression symptoms in participants with neuropathological AD
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Investigator: Stark, Susan L.
Project Title: Functional Loss as a Non-cognitive Marker of Preclinical AD
Date: [153]
Request ID: D1405
Aim 1: Determine the prevalence of functional decline related to the systemic deficits of AD among older adults with preclinical AD (defined by AD biomarkers)
Aim 2: Identify the relationship of functional decline to preclinical AD (defined by AD biomarkers)
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Investigator: Anish Mitra
Project Title: The Gene expression basis of amyloid distribution in Alzheimer’s Disease
Date: [153]
Request ID: D1404
Aim 1: Relate spatial patterns of gene expression to the spatial topography of amyloid distribution in the brain
Aim 2: Investigate genes whose spatial expression profile matches amyloid and aerobic glycolysis in the brain
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Investigator: Tae Sung Lim
Project Title: Neuropathological features of slowly progressive dementia
Date: [153]
Request ID: D1403
Aim 1: To compare the neuropathological features between DAT with and without progression in global CDR 0.5 and 1
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