The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Brooke Sadler
Project Title: The Evolutionary Role of Nicotinic Receptors in Memory and Cognitive Performance
Date: [153]
Request ID: D1210
Aim 1: Examine association between genotypes in nicotinic receptors with phenotypes related to cognition
Aim 2: Determine if these genotypes are at different frequencies among AD vs non AD participants
Aim 3: Relate these frequency differences back to historical selective pressures on increased cognition
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Investigator: Phillip Hsu
Project Title: Risk factors associated with Headache due to Lumbar Puncture
Date: [153]
Request ID: D1209
Aim 1: To identify risk factors that increase the likelihood of a post-Lumbar Puncture headache
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Investigator: Zheyu Wang
Project Title: Biomarker Evaluation in the Absence of a Gold Standard
Date: [153]
Request ID: D1208
Aim 1: Methodology development on evaluating biomarkers in the absence of a gold standard
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Investigator: Catherine M. Roe
Project Title: Alzheimer’s disease biomarkers and cancer
Date: [153]
Request ID: D1207
Aim 1: To examine whether Alzheimer’s disease biomarkers are associated with cancer
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Investigator: Chengjie Xiong
Project Title: Two Preclinical Latent Scores to Predict Occurrence of DAT
Date: [153]
Request ID: D1206
Aim 1: Assess the antecedent longitudinal changes and their predictive power of DAT for individual items of
Aim 2: Aim 2. Evaluate the use of IRT
Aim 3: Develop clinically meaningful score reports
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Investigator: Joshua Shimony
Project Title: Resting State Networks (RSN) in Cerebrovascular Disease
Date: [153]
Request ID: D1205
Aim 1: Compare RSN in patients with cerebrovascular to age matched normal controls.
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Investigator: Xiong
Project Title: ROLE OF IMPAIRED COGNITIVE STATES & RISK FACTORS IN CONVERSION TO MIXED DEMENTIAS
Date: [153]
Request ID: D1204
Aim 1: To merge databases from 6 large projects to rigorously analyse longitudinal data
Aim 2: to identify intervening states between normal cognition and dementia
Aim 3: to study transitions and associated risk factors
Aim 4: to standardize neuropathological across databaese to allow analysis of novel pathogenic determinantc
Investigator: Dave Balota
Project Title: The Effects of Alzheimer’s Disease and Aging on Cortical Myelination
Date: [153]
Request ID: D1203
Aim 1: Estimate changes in cortical myelination in healthy aging
Aim 2: Estimate changes in cortical myelination in Alheimer’s disease
Aim 3: Examine the robustness of this technique in two independent samples of healthy older adults
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Investigator: Allitia DiBernardo
Project Title: ADRC data modeling to support DIAN trial planning
Date: [153]
Request ID: D1202
Aim 1: Establish longitudinal biomarker profiles in amyloid+ cogntively normal subjects
Aim 2: Establish longitudinal cognitive profiles in amyloid+ cognitively normal subjects
Aim 3: Establish longitudinal biomarker profles in amyloid+ MCI subjects
Aim 4: Evaluate cognitive composites for CN and MCI amyloid+ subjects
Investigator: Andrei Vlassenko
Project Title: Regional beta-amyloid deposition in cognitively normal older adults
Date: [153]
Request ID: D1201
Aim 1: Examine regional differences in PIB BP in PIB-negative older compared to younger adults
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