The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: John C. Morris
Project Title: Correlation of AD biomarkers with CDR 0.5 diagnoses
Date: December 21, 2021 at 5:18 pm
Request ID: D1115
Aim 1: Correlate PIB retention with CDR 0.5 diagnoses
Aim 2: Correlate CSF levels of Abeta and tau with CDR 0.5 diagnoses
Aim 3: Correlate nWBV and hippocampal volume with CDR 0.5 diagnoses
Aim 4: Correlate pyschometric performance with CDR 0.5 diagnoses
Investigator: Joel Perlmutter
Project Title: Effects of Parkinson’s Disease on BOLD Functional Connectivity
Date: December 21, 2021 at 5:18 pm
Request ID: D1118
Aim 1: Study effects of PD on BOLD FC in subcortical areas
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Investigator: Joanne Conover
Project Title: Ventricular Expansion and Leakiness in Normal Aging
Date: December 21, 2021 at 5:18 pm
Request ID: D1122
Aim 1: Regional Trends in Expansion and Hyperintensities Using FLAIR-MRI
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Investigator: Carlos Cruchaga/Alison Goate
Project Title: To test whether the poly-T polymorphism (rs10524523) is associated with change in gray matter volume
Date: December 21, 2021 at 5:18 pm
Request ID: D1125
Aim 1: Try to replicate the Dr. Sager neuroimaging findings in a larger series
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Investigator: Carolyn Baum
Project Title: Contribution to a Metaanalysis on Apraxia
Date: December 21, 2021 at 5:18 pm
Request ID: D1116
Aim 1: To respond to a request from Francois Osiurak, PhD, for data that was already published
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Investigator: Alison Goate
Project Title: TOMM40 and neuroimaging phenotypes
Date: December 21, 2021 at 5:18 pm
Request ID: D1111
Aim 1: Test hypothesis from Mark Sager regarding relationship between TOMM40 genotypes and neuroimaging phe
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Investigator: Dr. John C. Morris
Project Title: The rule of sleep, personality, and aging: How these interactions affect cognition
Date: December 21, 2021 at 5:18 pm
Request ID: D1119
Aim 1: When comparing CDR 0 to CDR 0.5, 0.5’s would have higher levels of neuroticism & sleep difficulties
Aim 2: Within CDR0, those with high neuroticism & sleep difficulties will have lower cognition performance
Aim 3: Of those who progress to higher CDR, more of the high neuroticism and sleep problems group
Aim 4: High neuroticism group show more awakening and activity on actigraphs
Investigator: David Holtzman
Project Title: Clinicopathologic Characterization of Late-Onset Autosomal Dominant AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1126
Aim 1: Identify clinical charactersitics of family LO6 who harbor PSEN1 A79V mutations
Aim 2: Examine CSF and Imaging biomarkers in individuals from family LO6
Aim 3: Compare clinical and biomarker data between LO6 and early-onset kindreds with PSEN1 A79V mut
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Investigator: Chengjie Xiong
Project Title: Wavelet-based statistical analysis on brain functional connectivity
Date: December 21, 2021 at 5:18 pm
Request ID: D1222
Aim 1: Develop novel quantitative tools to comprehensively measure brain functional connectivity
Aim 2: Develop novel stat. methods to identify impairments of brain func. connectivity in elderly individua
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Investigator: JC Morris
Project Title: Testing the hypothesized stages of pre-clinical AD
Date: December 21, 2021 at 5:18 pm
Request ID: D1221
Aim 1: Identify the NIA-AA stages of preclinical AD by CSF markers in cognitively normal individuals
Aim 2: Investigate the predictive accuracy of these stages for cognitive and clinical decline
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