The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
Search Terms:
Investigator: Jorge J Llibre-Guerra
Project Title: Proposal for comparison between Dominantly Inherited Alzheimer Disease and sporadic early-onset Alzheimer’s disease.
Date: [153]
Request ID: D2015
Aim 1: To compare clinical presentation, neuropsychological performance and cognitive decline rate between DIAD and sporadic EOAD.
Aim 2: To examine in vivo the regional distribution of tau, amyloid-β, brain glucose metabolism, and structural atrophy, as well as their relationships, in DIAD and sporadic EOAD.
Aim 3: To compare CSF biomarkers levels and rate of change in DIAD and sporadic EOAD.
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Investigator: Kyoungjune Pak
Project Title: the association between amyloid deposition and obesity
Date: [153]
Request ID: D2014
Aim 1: to analyze the association between amyloid deposition by PET and obesity
Aim 2: to analyze the effect of Apo E genotyping on the association between amyloid deposition and obesity
Aim 3: to analyze the effect of aging on the association between amyloid deposition and obesity
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Investigator: Nicole S. McKay
Project Title: Harmonization and Validation of the Cognitive Batteries Administered Across the Knight ADRC Research Cohorts.
Date: [153]
Request ID: D2013
Aim 1: The main aim of this project is to harmonize the various cognitive batteries administered across the ADRC
Aim 2: Create one simple cognitive dataset that would allow comparisons across individuals who participated in different Knight ADRC studies
Aim 3: Evaluate how well the derived scores compare to traditional composites in classification of amyloid positive and negative individuals
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Investigator: Mary Jo LaDu
Project Title: APOE genotype frequencies and associated AD risk in African American, Afro-Caribbean, and African populations
Date: [153]
Request ID: D2012
Aim 1: Establish APOE genotype frequencies and relative risk for AD and cognitive decline in African American, Afro-Caribbean, African, and other African descendant populations via meta-analytic approaches.
Aim 2: Review literature for genetic variations and associated AD risk within the APOE gene cluster for individuals with African Ancestry.
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Investigator: Daniel Mroczek
Project Title: Personality Predictors of Dementia Onset and Progression: An Integrated Data Analysis
Date: [153]
Request ID: D2011
Aim 1: Examine whether baseline personality and indicators of psychological well-being (Positive Affect, Negative Affect) prospectively predict dementia onset.
Aim 2: Examine whether baseline personality and indicators of psychological well-being (Positive Affect, Negative Affect) prospectively disease progression (i.e. cognitive decline) following dementia diagnosis.
Aim 3: Use an integrated data analytic framework to investigate overall and sample-specific personality predictors of dementia onset and progression in six longitudinal studies.
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Investigator: Abhinav Jha
Project Title: Quantitative brain SPECT to measure severity of Parkinson’s disease
Date: [153]
Request ID: D2010
Aim 1: Develop and validate a new transmission-less attenuation compensation method for brain SPECT
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Investigator: Alison Goate
Project Title: Age extremes x APOE genotype sampling for genetic discovery in Alzheimer�s disease
Date: [153]
Request ID: D2009
Aim 1: Use multi-ethnic sequencing data from AD cases and cognitively normal controls to identify variants, genes, and genesets that protect against or accelerate disease
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Investigator: Jin-Tai Yu
Project Title: Genome-wide association study of brain amyloid and tau deposition
Date: [153]
Request ID: D2008
Aim 1: We aimed to do GWAS about different biomarkers in AD and other dementia disease, in order to find more meaningful SNPs
Aim 2: We aimed to explore the gene and protein undermine the SNPs about AD and other demential disease, especially about the amyloid and tau
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Investigator: Hongyu An
Project Title: PET/MR attenuation correction
Date: [153]
Request ID: D2007
Aim 1: To develop a deep learning based attenuation correct method for PET/MR imaging
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Investigator: Gagan S. Wig
Project Title: Examination of how changes in brain structure relates to changes in functional brain networks in adult individuals
Date: [153]
Request ID: D2006
Aim 1: examining whether increasing age is associated with changes in functional brain networks within individuals
Aim 2: determining whether an individual�s neuroanatomical changes relate to their functional brain network changes
Aim 3: determining whether age-associated cognitive changes can be explained by the joint influence of changes in brain anatomy and functional brain network organization
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