The Knight ADRC has supported many investigators at Washington University and at other institutions over the years. We wish to avoid the situation where two investigators study the same research question to avoid duplication of effort and potential conflict. To determine if your topic has already been studied with our resources, please search our database. If you find that your topic or a related topic has been submitted, you may wish to contact the investigator to inquire about their findings to determine how you might proceed. You may wish to collaborate or modify your request to avoid overlap. The results below reflect requests made since online requests have been accepted. As such, not all fields will have data as certain information, such as aims, were not collected until recently. If an entry has been assigned an ID number (e.g. T1004), the full request has been submitted and is either approved, disapproved or in process. If an entry has no ID number, then it represents a submission that has not yet been reviewed. Search terms are applied across an entire requests application including variables not displayed below. A more specific, detailed search may yield better results depending upon your needs.
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Investigator: Nelly Joseph-Mathurin
Project Title: Pathology correlates of biomarkers for neurovascular unit dysfunction in AD
Date: February 1, 2024 at 12:14 pm
Request ID: D2402
Aim 1: Evaluate the relationship between CSF proteomics of NVU-related proteins against neuropathology at a global level
Aim 2: Evaluate the relationship between imaging biomarkers of vascular changes and neuropathology at global and regional levels
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Investigator: Qian Liu
Project Title: Fusing Genomics and Neuroimaging: A Deep Learning Approach to diagnose Alzheimer’s Disease
Date: January 25, 2024 at 10:25 pm
Request ID: D2401
Aim 1: Design and implement a deep learning model that effectively integrates genomics data with neuroimaging findings to identify biomarkers indicative of Alzheimer’s Disease.
Aim 2: Utilize the combined power of genomics and neuroimaging data to improve the accuracy and reliability of Alzheimer’s Disease diagnosis, surpassing the capabilities of models that rely on single-modality data.
Aim 3: Discover and analyze new correlations between genetic factors and brain imaging patterns in Alzheimer’s patients, contributing to a deeper understanding of the disease’s pathogenesis and aiding in the development of targeted treatments.
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Investigator: Qing Wang
Project Title: Association of CSF sTREM2 and plasma GFAP with an MRI measure of neuroinflammation
Date: December 18, 2023 at 1:24 pm
Request ID: D2343
Aim 1: compare DBSI neuroinflammation index to in vivo CSF and plasma inflammation biomarkers (sTREM2 and GFAP) in the Knight ADRC cohorts
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Investigator: Shulan Hsieh
Project Title: Age prediction using resting state functional MRI
Date: December 15, 2023 at 2:49 am
Request ID: D2342
Aim 1: Compare model results by applying our developed model with the Data used in Millar et al. 2022 “Predicting brain age from functional connectivity in symptomatic and preclinical Alzheimer disease”
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Investigator: Marta Stojanovic
Project Title: Affective mechanisms of the decline in physical activity in preclinical AD
Date: December 13, 2023 at 2:27 pm
Request ID: D2341
Aim 1: Examine whether AD pathology and mood contribute to physical activity.
Aim 2: Examine whether AD pathology and affective response to exercise contribute to physical activity.
Aim 3: Examine whether AD pathology and affective network connectivity contribute to physical activity.
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Investigator: Chihiro Sato
Project Title: Sex differences in Tau aggregation measured by Tau PET vs MTBR-tau
Date: December 8, 2023 at 12:30 am
Request ID: D2340
Aim 1: Determine sex-specific differences in Tau PET in AD vs age matched control
Aim 2: Determine sex-specific differences in CSF MTBR-tau243 in AD vs age matched control
Aim 3: Compare sex-specific differences measured by Tau PET vs CSF MTBR-tau243 in AD vs age matched control
Aim 4: Perform all analyses stratified by APOE genotype.
Investigator: Sarah Hartz
Project Title: Dementia screen in absence of collateral source
Date: November 16, 2023 at 12:34 pm
Request ID: D2339
Aim 1: Use existing data to develop and evaluate a screening tool that can be administered without a collateral source
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Investigator: Karin Meeker
Project Title: Biomarker Clustering in Late Onset Alzheimer Disease
Date: November 16, 2023 at 11:30 am
Request ID: D1915 addendum
Aim 1: Assess the cross-sectional relationships among AD biomarkers and their ability to predict meaningful clinical outcomes.
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Investigator: Susy Stark
Project Title: Falls and Preclinical Alzheimer Disease: Mechanisms of functional performance among cognitively normal (CN) older adults
Date: November 1, 2023 at 2:10 pm
Request ID: S1803 amendment
Aim 1: Determine the relationship between brain age and falls among CN older adults.
Aim 2: Determine the relationship between brain age and complex daily task performance among CN older adults.
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Investigator: Alison Goate
Project Title: Uncovering the genetic mechanisms of the Chromosome 17q21.31 Tau haplotype on neurodegeneration risk in FTD and PSP
Date: October 30, 2023 at 11:27 am
Request ID: D2338
Aim 1: Determine impact of H1/H2 haplotypes on gene expression and regulation in human brain across ancestries. Using single nuclear multi-omics and proteomics in brain tissue, we will assess haplotype and cell-type specific differences in gene regulation individuals of European and African ancestry.
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